INT447

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Context Info
Confidence 0.75
First Reported 1979
Last Reported 2010
Negated 0
Speculated 1
Reported most in Abstract
Documents 4
Total Number 5
Disease Relevance 0.76
Pain Relevance 1.80

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

mitochondrion (Comt) plasma membrane (Comt) cytoplasm (Comt)
Anatomy Link Frequency
ganglion 1
Comt (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Catechol-O-methyltransferase 59 100.00 Very High Very High Very High
Enkephalin 13 100.00 Very High Very High Very High
Catecholamine 5 100.00 Very High Very High Very High
Serotonin 6 99.60 Very High Very High Very High
Neuropeptide 1 99.60 Very High Very High Very High
monoamine 3 98.96 Very High Very High Very High
Dopamine 23 98.64 Very High Very High Very High
substance P 3 98.44 Very High Very High Very High
opiate 3 96.84 Very High Very High Very High
dopamine receptor 2 93.92 High High
Disease Link Frequency Relevance Heat
Ganglion Cysts 1 91.96 High High
Alcohol Addiction 32 90.04 High High
Alcoholic Liver Diseases 41 76.12 Quite High
Drug Dependence 3 63.68 Quite High
Disease 57 52.76 Quite High
Body Weight 1 44.36 Quite Low
Flushing 1 35.96 Quite Low
Hepatotoxicity 9 10.32 Low Low
Cirrhosis 37 5.00 Very Low Very Low Very Low
Alcoholic Hepatitis 21 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
COMT is
               located in higher concentrations in the membranes of the gastrointestinal
                   tract.26–30 Generally, these physicochemical
               properties of a drug also affect its absorption through the gastrointestinal
                   tract.26,31 Compounds including LD are weak bases or weak
               acids or are the salts of these, and as such demonstrate pH-dependent solubility.
               
Localization (located) of COMT associated with catechol-o-methyltransferase
1) Confidence 0.75 Published 2009 Journal Patient Prefer Adherence Section Body Doc Link PMC2778405 Disease Relevance 0.05 Pain Relevance 0.18
The specific markers include: 1) the immunocytochemical localization of the catecholamine-synthesizing enzyme tyrosine hydroxylase, and the neuropeptides enkephalin and substance P; and 2) the radioautographic localization of [3H]serotonin (5-hydroxytryptamine) and 3H-labeled amino acids anterogradely transported from the nodose ganglion.
Localization (localization) of catecholamine-synthesizing enzyme tyrosine hydroxylase in ganglion associated with ganglion cysts, catecholamine, neuropeptide, enkephalin, serotonin and substance p
2) Confidence 0.56 Published 1984 Journal Fed. Proc. Section Abstract Doc Link 6209170 Disease Relevance 0.09 Pain Relevance 0.38
Thus, several genes have been described including monoamine oxidase A (MAOA), the serotonin transporter (HTT), catechol-O-methyltransferase (COMT), the corticotropin releasing hormones receptor 1 gene and the dopamine transporter [8,11,13–15].
Localization (releasing) of catechol-O-methyltransferase associated with catechol-o-methyltransferase, dopamine, serotonin and monoamine
3) Confidence 0.52 Published 2010 Journal International Journal of Environmental Research and Public Health Section Body Doc Link PMC2898022 Disease Relevance 0.62 Pain Relevance 0.45
We examined the dual immunocytochemical localization of antisera raised against Leu5-enkephalin and the catecholamine-synthesizing enzyme, tyrosine hydroxylase (TH), to determine the cellular substrates for these and/or other functional interactions.
Spec (examined) Localization (localization) of catecholamine-synthesizing enzyme associated with catecholamine and enkephalin
4) Confidence 0.07 Published 1992 Journal J. Neurosci. Res. Section Abstract Doc Link 1349353 Disease Relevance 0 Pain Relevance 0.48
The experimental procedures and the results obtained using this technique for the localization of the catecholamine synthesizing enzyme, tyrosine hydroxylase, are described.
Localization (localization) of catecholamine synthesizing enzyme associated with catecholamine
5) Confidence 0.02 Published 1979 Journal Fed. Proc. Section Abstract Doc Link 39006 Disease Relevance 0 Pain Relevance 0.31

General Comments

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