INT44711

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Context Info
Confidence 0.22
First Reported 1984
Last Reported 1996
Negated 0
Speculated 2
Reported most in Abstract
Documents 3
Total Number 5
Disease Relevance 0.75
Pain Relevance 1.99

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

carbohydrate metabolic process (Man2a2)
Anatomy Link Frequency
VMH 2
APC 2
platelet 2
cortex 2
Man2a2 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Clonidine 6 100.00 Very High Very High Very High
Morphine 7 99.98 Very High Very High Very High
Analgesic 2 98.48 Very High Very High Very High
Anterior cingulate cortex 6 94.04 High High
cerebral cortex 1 93.80 High High
Locus ceruleus 5 84.24 Quite High
noradrenaline 6 80.80 Quite High
antagonist 2 77.76 Quite High
Catecholamine 1 77.12 Quite High
agonist 3 75.00 Quite High
Disease Link Frequency Relevance Heat
Appetite Loss 6 92.08 High High
Stress 4 86.48 High High
Mydriatic 1 70.72 Quite High
Attention Deficit Hyperactivity Disorder 1 52.96 Quite High
Hypotension 1 35.52 Quite Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The 60 day-old offspring showed only a reduced alpha 2 binding which appeared to have no regional specificity.
Negative_regulation (reduced) of alpha 2 Spec (appeared) Binding (binding) of
1) Confidence 0.22 Published 1984 Journal Pharmacol. Biochem. Behav. Section Abstract Doc Link 6494211 Disease Relevance 0.31 Pain Relevance 0.17
Binding of [3H]p-aminoclonidine to alpha 2 receptors determined that alpha 2 binding was decreased the most in APC (P < 0.0003).
Negative_regulation (decreased) of alpha 2 Spec (determined) Binding (binding) of in APC
2) Confidence 0.13 Published 1996 Journal Brain Res. Mol. Brain Res. Section Abstract Doc Link 8717338 Disease Relevance 0.16 Pain Relevance 0.29
There were no significant changes in LH or VMH, although alpha 2-noradrenergic binding in VMH tended to decrease with the severe IMB in a pattern similar to APC.
Negative_regulation (decrease) of alpha 2 Binding (binding) of in VMH
3) Confidence 0.09 Published 1996 Journal Brain Res. Mol. Brain Res. Section Abstract Doc Link 8717338 Disease Relevance 0.15 Pain Relevance 0.25
In addition, ABT-200 potently inhibited binding of [3H]-rauwolscine to alpha-2 adrenergic receptors with a Ki value in radioligand binding assays of approximately 1 nM in the rat cortex and was much less potent at other receptor binding sites.
Negative_regulation (inhibited) of alpha-2 Binding (binding) of in cortex
4) Confidence 0.08 Published 1995 Journal J. Pharmacol. Exp. Ther. Section Abstract Doc Link 7891328 Disease Relevance 0.12 Pain Relevance 0.14
A recent report showed that morphine inhibited [3H]clonidine binding to human platelet alpha 2 receptors.
Negative_regulation (inhibited) of alpha 2 Binding (binding) of in platelet associated with clonidine and morphine
5) Confidence 0.05 Published 1995 Journal Br J Anaesth Section Abstract Doc Link 7880711 Disease Relevance 0 Pain Relevance 1.14

General Comments

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