INT44717

Context Info Confidence 0.75 First Reported 1984 Last Reported 2010 Negated 0 Speculated 0 Reported most in Abstract Documents 12 Total Number 15 Disease Relevance 13.44 Pain Relevance 3.72

signal transduction (TNFSF14) extracellular space (TNFSF14) extracellular region (TNFSF14) plasma membrane (TNFSF14) cytoplasm (TNFSF14)

Anatomy Link Frequency plasmacytes 1 B-lymphocyte 1 bone marrow 1 bladder 1 foam cell 1 TNFSF14 (Homo sapiens)

Pain Link Frequency Relevance Heat Lamotrigine 40 100.00 chemokine 2 99.90 antiepileptic Drug 132 99.86 Angina 3 99.84 interstitial cystitis 4 97.96 Pain 5 97.44 Multiple sclerosis 8 95.16 backache 1 93.36 Inflammatory response 2 93.12 Nerve growth factor 3 92.16

Disease Link Frequency Relevance Heat Myocardial Infarction 4 99.92 Infantile Spasms 36 99.84 Amyloid Plaque 1 99.84 Cv General 3 Under Development 1 99.84 Syndrome 563 99.80 Coronary Heart Disease 1 99.60 Multiple Myeloma 7 99.50 Partial Seizures 16 99.16 Convulsion 500 99.08 Epilepsy 388 98.64

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Flow cytometry analysis demonstrates a monoclonal pattern of immunoglobulin light chain expression.

Gene_expression (expression) of light

1) Confidence 0.75 Published 2006 Journal JOP Section Abstract Doc Link 16685107 Disease Relevance 1.38 Pain Relevance 0.14

Multiple myeloma is characterized by the production of a monoclonal immunoglobulin, free monoclonal light chains, or both.

Gene_expression (production) of light associated with multiple myeloma

2) Confidence 0.75 Published 1997 Journal Postgrad Med Section Abstract Doc Link 9336606 Disease Relevance 0.77 Pain Relevance 0.10

Biopsy of the mass revealed immature plasmacytes with very faint cytoplasmic expression of kappa light chains.

Gene_expression (expression) of light in plasmacytes

3) Confidence 0.75 Published 2001 Journal Ann. Hematol. Section Abstract Doc Link 11669309 Disease Relevance 1.78 Pain Relevance 0.09

CXCR3 binding chemokine and TNFSF14 over expression in bladder urothelium of patients with ulcerative interstitial cystitis.

Gene_expression (expression) of TNFSF14 in bladder associated with chemokine and interstitial cystitis

4) Confidence 0.67 Published 2010 Journal J. Urol. Section Title Doc Link 20096889 Disease Relevance 0.10 Pain Relevance 0.24

A kappa-light chain M component and kappa-light chain-restricted bone marrow plasmacytosis were detected.

Gene_expression (detected) of light in bone marrow

5) Confidence 0.65 Published 2003 Journal Acta Med. Austriaca Section Abstract Doc Link 12558564 Disease Relevance 0.79 Pain Relevance 0.09

Further tests, including immunoglobulin electrophoresis and assay of the serum levels of kappa and lambda light chains, demonstrated that his myeloma was of the IgM, kappa subtype.

Gene_expression (electrophoresis) of light

6) Confidence 0.65 Published 1999 Journal Ann. Hematol. Section Abstract Doc Link 10089027 Disease Relevance 0.10 Pain Relevance 0.09

CSF measurements included immunoglobulin G (IgG) synthesis, IgG ratio, myelin basic protein, IgG kappa light chains, and oligoclonal banding.

Gene_expression (synthesis) of light

7) Confidence 0.65 Published 1996 Journal Neurology Section Abstract Doc Link 8614496 Disease Relevance 1.35 Pain Relevance 0.87

Diagnosis of acute myocardial infarction by detection of circulating cardiac myosin light chains.

Gene_expression (detection) of light associated with myocardial infarction

8) Confidence 0.65 Published 1984 Journal Am. J. Cardiol. Section Title Doc Link 6496359 Disease Relevance 0.66 Pain Relevance 0.15

CONCLUSIONS: Our study using DNA microarray analysis followed by quantitative real-time polymerase chain reaction reveals over expression of genes related to immune and inflammatory responses, including T-helper type 1 related chemokines, and cytokines such as CXCR3 binding chemokines and TNFSF14.

Gene_expression (expression) of TNFSF14

9) Confidence 0.60 Published 2010 Journal J. Urol. Section Body Doc Link 20096889 Disease Relevance 0 Pain Relevance 0

The sister still alive showed renal impairment and deep venous thrombosis associated with lupus anticoagulant activity, decrease of circulating autoreactive CD5 (+) B lymphocytes and increased urinary levels of IgG and kappa and lambda light chains, suggesting a possible defect in regulation of B-lymphocyte function.

Gene_expression (levels) of light in B-lymphocyte associated with systemic lupus erythematosus and thrombosis related under development

10) Confidence 0.58 Published 2005 Journal Neuropediatrics Section Abstract Doc Link 16138253 Disease Relevance 1.33 Pain Relevance 0.60

Enhanced plasma levels of LIGHT in unstable angina: possible pathogenic role in foam cell formation and thrombosis.

Gene_expression (levels) of LIGHT in foam cell associated with angina and thrombosis

11) Confidence 0.36 Published 2005 Journal Circulation Section Title Doc Link 16186421 Disease Relevance 0.38 Pain Relevance 0.19

LTG, with its Na+ channel blocking actions, was initially introduced for add-on therapy of focal seizures in adults, but it was rapidly demonstrated that it was a broad spectrum AED.

Gene_expression (introduced) of LTG associated with convulsion and lamotrigine

12) Confidence 0.04 Published 2008 Journal Neuropsychiatric Disease and Treatment Section Body Doc Link PMC2646636 Disease Relevance 1.19 Pain Relevance 0.32

Four AEDs (FBM, LTG, TPM and RUF) have been officially licensed for LGS after demonstrating significant efficacy in randomized, double-blind, placebo controlled studies.

Gene_expression (licensed) of LTG associated with syndrome, lamotrigine and antiepileptic drug

13) Confidence 0.04 Published 2008 Journal Neuropsychiatric Disease and Treatment Section Body Doc Link PMC2646636 Disease Relevance 1.00 Pain Relevance 0.24

More recently (Cianchetti et al 2002; Conry 2004), LTG was shown to be effective in West syndrome.

Gene_expression (effective) of LTG associated with infantile spasms and lamotrigine

14) Confidence 0.04 Published 2008 Journal Neuropsychiatric Disease and Treatment Section Body Doc Link PMC2646636 Disease Relevance 1.42 Pain Relevance 0.27

Titration of LTG thus requires careful attention, especially in children.

Gene_expression (Titration) of LTG associated with lamotrigine

15) Confidence 0.04 Published 2008 Journal Neuropsychiatric Disease and Treatment Section Body Doc Link PMC2646636 Disease Relevance 1.20 Pain Relevance 0.33

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