INT44731

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Context Info
Confidence 0.76
First Reported 1984
Last Reported 2005
Negated 2
Speculated 0
Reported most in Abstract
Documents 4
Total Number 4
Disease Relevance 0.83
Pain Relevance 1.58

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

plasma membrane (Slc5a7) transmembrane transport (Slc5a7)
Anatomy Link Frequency
tail 1
astrocytes 1
Slc5a7 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
tail-flick 4 100.00 Very High Very High Very High
intrathecal 3 99.98 Very High Very High Very High
Intracerebroventricular 1 99.80 Very High Very High Very High
Pain 7 99.44 Very High Very High Very High
antagonist 1 90.88 High High
Clonidine 4 87.92 High High
antinociception 4 79.04 Quite High
Desipramine 1 76.76 Quite High
agonist 3 75.28 Quite High
Antinociceptive 1 75.00 Quite High
Disease Link Frequency Relevance Heat
Pain 5 99.44 Very High Very High Very High
Pressure Volume 2 Under Development 1 97.52 Very High Very High Very High
Hypertension 5 92.84 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The Na(+)-coupled high affinity choline transporter CHT1 is not expressed in these cells as evidenced by RT-PCR.
Neg (not) Gene_expression (expressed) of CHT1
1) Confidence 0.76 Published 2001 Journal Biochim. Biophys. Acta Section Abstract Doc Link 11406107 Disease Relevance 0 Pain Relevance 0.08
The high-affinity Na+-dependent choline transporter, CHT1, is not expressed in astrocytes as evidenced by RT-PCR.
Neg (not) Gene_expression (expressed) of CHT1 in astrocytes
2) Confidence 0.56 Published 2005 Journal J. Neurochem. Section Abstract Doc Link 16000150 Disease Relevance 0 Pain Relevance 0.11
Intracerebroventricular (i.c.v.) injection of hemicholinium-3 (HC-3) in SHR evoked a fall in arterial pressure through inhibition of acetylcholine synthesis.
Gene_expression (injection) of hemicholinium-3 associated with intracerebroventricular
3) Confidence 0.29 Published 1984 Journal Hypertension Section Abstract Doc Link 6500669 Disease Relevance 0.40 Pain Relevance 0.22
Intrathecal hemicholinium-3 (HC-3), a reversible inhibitor of choline transporter, did not change the effect of BCh in the tail flick test but produced a non-significant reduction of the effect of BCh against incisional pain.
Gene_expression (produced) of hemicholinium-3 in tail associated with pain, tail-flick and intrathecal
4) Confidence 0.16 Published 2004 Journal Brain Res. Section Abstract Doc Link 15276888 Disease Relevance 0.43 Pain Relevance 1.17

General Comments

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