INT44745

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Context Info
Confidence 0.65
First Reported 1984
Last Reported 2009
Negated 0
Speculated 0
Reported most in Abstract
Documents 5
Total Number 5
Disease Relevance 2.04
Pain Relevance 4.92

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

nuclear envelope (Nrm) nucleus (Nrm)
Anatomy Link Frequency
medulla 1
neurons 1
STN 1
Nrm (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Raphe magnus 33 100.00 Very High Very High Very High
Morphine 13 100.00 Very High Very High Very High
medulla 11 100.00 Very High Very High Very High
gABA 8 100.00 Very High Very High Very High
Glutamate 5 100.00 Very High Very High Very High
Central grey 14 99.84 Very High Very High Very High
Spinal cord 11 99.16 Very High Very High Very High
agonist 30 98.96 Very High Very High Very High
Opioid 20 98.84 Very High Very High Very High
opioid receptor 123 98.78 Very High Very High Very High
Disease Link Frequency Relevance Heat
Urological Neuroanatomy 14 99.84 Very High Very High Very High
Frailty 5 99.64 Very High Very High Very High
Neuropathic Pain 11 97.28 Very High Very High Very High
Skin Allergy 1 96.40 Very High Very High Very High
Nociception 8 95.44 Very High Very High Very High
Pain 25 77.40 Quite High
Cancer 1 75.00 Quite High
Contusions 2 71.68 Quite High
Injury 7 70.88 Quite High
Shock 1 62.44 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
OBJECTIVES: To evaluate whether the current European Association for Palliative Care recommendation regarding the starting dose of 5 mg of normal-release morphine (NRM) sulfate oral solution every 4 hours in opioid naive patients or 10 mg in patients already being treated with "weak" opioids is effective and could be proposed as starting routine dose in clinical practice.
Localization (release) of NRM associated with opioid, morphine and palliative
1) Confidence 0.65 Published 2009 Journal Clin J Pain Section Abstract Doc Link 19454871 Disease Relevance 0.15 Pain Relevance 0.86
It is released there mainly by descending axons of the medulla's nucleus raphe magnus (NRM).
Localization (released) of NRM in medulla associated with raphe magnus and medulla
2) Confidence 0.62 Published 2009 Journal J Rehabil Res Dev Section Abstract Doc Link 19533524 Disease Relevance 1.07 Pain Relevance 0.74
On the other hand, the lowest release of GABA and taurine was found in the STN (696 +/- 91 and 305 +/- 25%, respectively), and glutamate and aspartate in the NRM (558 +/- 200 and 874 +/- 315%, respectively).
Localization (release) of NRM in STN associated with raphe magnus, glutamate and gaba
3) Confidence 0.45 Published 2008 Journal Neurochem. Res. Section Abstract Doc Link 17940899 Disease Relevance 0.34 Pain Relevance 1.01
However, others have reported a DOR-induced weak potassium current in a small population of NRM and PAG neurons [48,49], but DOR agonists have no significant effect on the presynaptic GABA release in these NRM or PAG neurons from normal animals [4,13,49].
Localization (release) of NRM in neurons associated with raphe magnus, gaba, agonist, opioid receptor and central grey
4) Confidence 0.34 Published 2007 Journal Mol Pain Section Body Doc Link PMC2219988 Disease Relevance 0.35 Pain Relevance 1.87
Recordings were also made from 12 neurones whose recording sites were located in the NRM and Ret.F.
Localization (located) of NRM associated with raphe magnus
5) Confidence 0.17 Published 1984 Journal Pain Section Abstract Doc Link 6504550 Disease Relevance 0.14 Pain Relevance 0.44

General Comments

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