INT44757

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Context Info
Confidence 0.53
First Reported 1984
Last Reported 2006
Negated 0
Speculated 0
Reported most in Title
Documents 3
Total Number 3
Disease Relevance 1.39
Pain Relevance 0.82

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

peptidase activity (PRCP) plasma membrane (PRCP) lysosome (PRCP)
Anatomy Link Frequency
neurons 1
PRCP (Homo sapiens)
Pain Link Frequency Relevance Heat
fluoxetine 1 99.80 Very High Very High Very High
antagonist 2 96.72 Very High Very High Very High
cannabis 16 94.48 High High
cocaine 28 94.08 High High
drug abuse 57 92.24 High High
sSRI 3 84.36 Quite High
addiction 4 60.16 Quite High
alcohol 4 59.72 Quite High
tolerance 1 54.40 Quite High
Physical dependence 1 52.88 Quite High
Disease Link Frequency Relevance Heat
Psychosis 5 98.52 Very High Very High Very High
Hypesthesia 1 98.08 Very High Very High Very High
Death 4 97.28 Very High Very High Very High
Vertigo 1 96.96 Very High Very High Very High
Ataxia 1 96.60 Very High Very High Very High
Ocular Toxicity (including Many Sub-types) 1 96.12 Very High Very High Very High
Poisoning 1 95.20 Very High Very High Very High
Drug Dependence 59 92.24 High High
Schizophrenia 3 86.76 High High
Stress 4 81.12 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
High doses of PCP produce disturbing manifestations including psychosis, numbness, light-headedness, vertigo, ataxia, and nystagmus due to acute intoxication.
Gene_expression (produce) of PCP associated with hypesthesia, ataxia, vertigo, psychosis, ocular toxicity (including many sub-types) and poisoning
1) Confidence 0.53 Published 1984 Journal Neurosci Biobehav Rev Section Abstract Doc Link 6514253 Disease Relevance 0.90 Pain Relevance 0.05
This identified 160 transcripts shared between the COC+, THC+ and PCP+ groups (Fig. 2B).
Gene_expression (groups) of PCP
2) Confidence 0.23 Published 2006 Journal PLoS ONE Section Body Doc Link PMC1762434 Disease Relevance 0.31 Pain Relevance 0.45
Fluoxetine prevents PCP- and MK801-induced HSP70 expression in injured limbic cortical neurons of rats.
Gene_expression (expression) of PCP in neurons associated with fluoxetine
3) Confidence 0.09 Published 2000 Journal Biol. Psychiatry Section Title Doc Link 10812043 Disease Relevance 0.18 Pain Relevance 0.31

General Comments

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