INT44773

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Context Info
Confidence 0.57
First Reported 1984
Last Reported 2007
Negated 0
Speculated 0
Reported most in Abstract
Documents 6
Total Number 6
Disease Relevance 2.32
Pain Relevance 2.03

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

nuclear envelope (LBR) small molecule metabolic process (LBR) nucleus (LBR)
DNA binding (LBR)
Anatomy Link Frequency
lymphocytes 1
nerve 1
skin 1
LBR (Homo sapiens)
Pain Link Frequency Relevance Heat
narcan 6 99.74 Very High Very High Very High
hypoalgesia 3 99.20 Very High Very High Very High
lidocaine 6 98.64 Very High Very High Very High
depression 1 98.40 Very High Very High Very High
anesthesia 4 89.00 High High
interneuron 3 86.56 High High
Pain 1 83.08 Quite High
headache 1 74.48 Quite High
Face pain 3 72.80 Quite High
Analgesic 1 72.40 Quite High
Disease Link Frequency Relevance Heat
Immunodeficiency 1 99.68 Very High Very High Very High
Hypoalagesia 3 99.20 Very High Very High Very High
Candida Infection 1 98.60 Very High Very High Very High
Depression 1 98.40 Very High Very High Very High
Nociception 15 90.16 High High
Pressure And Volume Under Development 2 83.48 Quite High
Pain 1 83.08 Quite High
Toxicity 5 75.92 Quite High
Toothache 1 75.08 Quite High
Skin Cancer 3 75.00 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
It was reported that TGR could reduce the production of Simian Immunodeficiency Virus (SIV) by inhibition of PHA stimulated 3H-TdR transportation in lymph cells as well as suppression of the Sister Chromatid Exchange frequency induced by mitomycin C in human peripheral lymphocytes [11,12].
Negative_regulation (inhibition) of PHA in lymphocytes associated with immunodeficiency
1) Confidence 0.57 Published 2007 Journal BMC Cancer Section Body Doc Link PMC2222640 Disease Relevance 0.65 Pain Relevance 0.15
Immediately, postsurgery, older children recovered fully their responsiveness to both PHA and Con A, while there was significant depression in their responsiveness to PWM (P less than 0.005) and SPA (P less than 0.05).
Negative_regulation (responsiveness) of PHA associated with depression
2) Confidence 0.42 Published 1984 Journal J. Pediatr. Surg. Section Abstract Doc Link 6520681 Disease Relevance 0.10 Pain Relevance 0.35
Conversely, preceding electrical stimuli to the supraorbital nerve suppressed the LBR.
Negative_regulation (suppressed) of LBR in nerve
3) Confidence 0.38 Published 2002 Journal J. Neurophysiol. Section Abstract Doc Link 11877513 Disease Relevance 0.24 Pain Relevance 0.32
Fentanyl injection induced strong, naloxone-reversible, LBR suppression (the response decreased to 25.3% of predrug values at 10 min and to 4% at 20 min), whereas R2 remained appreciably unchanged.
Negative_regulation (suppression) of LBR associated with narcan
4) Confidence 0.38 Published 2002 Journal J. Neurophysiol. Section Abstract Doc Link 11877513 Disease Relevance 0.28 Pain Relevance 0.56
When lidocaine began to induce hypoalgesia (about 5 min after the injection), the LBR was abolished, whereas R2 was only partly suppressed 10 min after the injection.
Negative_regulation (abolished) of LBR associated with hypoalgesia and lidocaine
5) Confidence 0.38 Published 2002 Journal J. Neurophysiol. Section Abstract Doc Link 11877513 Disease Relevance 0.34 Pain Relevance 0.57
Significant defects in global immunity shown by anergy to DTH skin testing in 7 of 16 patients and decreased proliferation to PHA (phytohemagglutinin) and CASTA, a Candida albicans protein extract, were observed.
Negative_regulation (decreased) of PHA in skin associated with candida infection
6) Confidence 0.03 Published 1999 Journal J. Immunother. Section Abstract Doc Link 10546159 Disease Relevance 0.71 Pain Relevance 0.08

General Comments

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