INT44775

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Context Info
Confidence 0.51
First Reported 1984
Last Reported 2010
Negated 0
Speculated 1
Reported most in Body
Documents 33
Total Number 36
Disease Relevance 6.20
Pain Relevance 8.65

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

Anatomy Link Frequency
eyes 2
neurons 2
margin 1
spike 1
cleavage 1
ap (Mus musculus)
Pain Link Frequency Relevance Heat
Action potential 3324 100.00 Very High Very High Very High
dorsal root ganglion 54 100.00 Very High Very High Very High
Angina 10 100.00 Very High Very High Very High
unmyelinated 144 96.40 Very High Very High Very High
cva 9 93.48 High High
ketamine 10 84.48 Quite High
fibrosis 9 78.68 Quite High
c fibre 18 75.12 Quite High
Inflammation 61 72.84 Quite High
Pain 48 72.32 Quite High
Disease Link Frequency Relevance Heat
Ganglion Cysts 67 100.00 Very High Very High Very High
Cv General 3 Under Development 14 100.00 Very High Very High Very High
Osteoporosis 33 97.92 Very High Very High Very High
Hemolysis 76 96.52 Very High Very High Very High
Disease 106 96.50 Very High Very High Very High
Retina Disease 10 94.88 High High
Targeted Disruption 8 94.40 High High
Cataract 5 92.16 High High
Ocular Toxicity (including Many Sub-types) 15 91.76 High High
Hypertension 1 90.04 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
In stable AP, the deterioration was accompanied by inadequacy augmentation, whereas in the adequate type, the improvement or remission led to the appearance of an AP attack at the height of the RS tension.
Gene_expression (appearance) of AP associated with angina
1) Confidence 0.51 Published 1984 Journal Ter. Arkh. Section Abstract Doc Link 6523406 Disease Relevance 1.06 Pain Relevance 0.83
AP expression was observed in the RPE, outer nuclear layer (ONL), inner nuclear layer (INL), OPL, inner plexiform layer (IPL), RGC layer and Müller cells but not the outer and inner segments of the photoreceptor (Figure 1C,E-H).
Gene_expression (expression) of AP in photoreceptor
2) Confidence 0.51 Published 2009 Journal Molecular Vision Section Body Doc Link PMC2713732 Disease Relevance 0.23 Pain Relevance 0
For AP and dystrophin expression, mouse eyes were enucleated and snap frozen in liquid nitrogen–cooled isopentane in optimal cutting temperature (OCT) compound (Sakura Finetek Inc., Torrance, CA).
Gene_expression (expression) of AP in eyes
3) Confidence 0.51 Published 2009 Journal Molecular Vision Section Body Doc Link PMC2713732 Disease Relevance 0.44 Pain Relevance 0.09
AP expression was not detected in the mock-infected control eyes (5 eyes each for young and adult mice; Figure 1B,D).
Gene_expression (expression) of AP in eyes
4) Confidence 0.44 Published 2009 Journal Molecular Vision Section Body Doc Link PMC2713732 Disease Relevance 0.28 Pain Relevance 0
After endogenous heat labile AP activity was heat inactivated, AAV-9 mediated AP expression was examined by histochemical staining using a previously described protocol [22-24].
Spec (examined) Gene_expression (expression) of AP
5) Confidence 0.44 Published 2009 Journal Molecular Vision Section Body Doc Link PMC2713732 Disease Relevance 0.36 Pain Relevance 0.07
AAV-9 resulted in widespread (peripheral to central to peripheral) and throughout (RPE to retinal ganglion cells [RGC]) AP expression in all age groups (Figure 1A, data not shown for young and old mice).
Gene_expression (expression) of AP in retinal ganglion cells associated with ganglion cysts
6) Confidence 0.39 Published 2009 Journal Molecular Vision Section Body Doc Link PMC2713732 Disease Relevance 0.19 Pain Relevance 0
Yet, in marked contrast to AP initiation, during AP propagation the ionic (Na and K) currents trail the early rising phase of the AP (in Figure 3C between ?
Gene_expression (initiation) of AP associated with action potential
7) Confidence 0.29 Published 2007 Journal PLoS Computational Biology Section Body Doc Link PMC1864994 Disease Relevance 0 Pain Relevance 0.48
The novel noise effects that we report depend on six basic factors that are fundamental to the mechanism of AP propagation, namely; a) Na channels supporting the AP have to open earlier than the opposing K channels, b) Na channels have to inactivate to allow for repetitive unidirectional signaling, c) channels are discrete all-or-none conductances, d) the fact that channels gate stochastically, e) the AP is locally initiated by a relatively small number of Na channels, due to the way that depolarization spreads in cables, and f) the single channel conductance approaches the input conductance of the membrane as axons become thinner.
Gene_expression (channels) of AP associated with action potential
8) Confidence 0.29 Published 2007 Journal PLoS Computational Biology Section Body Doc Link PMC1864994 Disease Relevance 0 Pain Relevance 0.26
The timing of APs within each set is not unique, but becomes unimodal (Figure 1, arrows A,B,C), or markedly multimodally distributed—forming visually distinct groups of APs (Figure 1, AP sets marked E).
Gene_expression (sets) of AP associated with action potential
9) Confidence 0.29 Published 2007 Journal PLoS Computational Biology Section Body Doc Link PMC1864994 Disease Relevance 0 Pain Relevance 0.71
Thus, propagation depends on the forward-flowing axial current produced by the rising AP.
Gene_expression (produced) of AP associated with action potential
10) Confidence 0.26 Published 2007 Journal PLoS Computational Biology Section Body Doc Link PMC1864994 Disease Relevance 0 Pain Relevance 0.33
This is because AP propagation is driven by axial currents depolarizing the membrane ahead, which then opens Na channels.
Gene_expression (propagation) of AP associated with action potential
11) Confidence 0.26 Published 2007 Journal PLoS Computational Biology Section Body Doc Link PMC1864994 Disease Relevance 0 Pain Relevance 0.45
Splitting is caused by gradual conduction fluctuations and jump-like events acting together in a structured manner, such as to systematically accelerate or decelerate APs within an AP set as it propagates along the axon.
Gene_expression (decelerate) of AP associated with action potential
12) Confidence 0.26 Published 2007 Journal PLoS Computational Biology Section Body Doc Link PMC1864994 Disease Relevance 0 Pain Relevance 0.26
We have previously shown that channel noise causes AP communication to break down in axons and soma below 0.1 ?
Gene_expression (communication) of AP in soma associated with action potential
13) Confidence 0.26 Published 2007 Journal PLoS Computational Biology Section Body Doc Link PMC1864994 Disease Relevance 0.07 Pain Relevance 0.33
Conduction variability is a direct, inescapable consequence of internal noise in the AP signaling system and will emerge whenever the input resistance of axons becomes so large that small numbers of ion channels can support AP conduction.
Gene_expression (conduction) of AP in internal associated with action potential
14) Confidence 0.26 Published 2007 Journal PLoS Computational Biology Section Body Doc Link PMC1864994 Disease Relevance 0 Pain Relevance 0.27
m–diameter axons, which implies that the safety factor of AP conduction is little affected by channel noise down to the smallest known axons.
Gene_expression (conduction) of AP associated with action potential
15) Confidence 0.26 Published 2007 Journal PLoS Computational Biology Section Body Doc Link PMC1864994 Disease Relevance 0 Pain Relevance 0.39
Therefore, the rising AP phase extends as far ahead as the forward axial current (in Figure 3C at ?
Gene_expression (phase) of AP associated with action potential
16) Confidence 0.26 Published 2007 Journal PLoS Computational Biology Section Body Doc Link PMC1864994 Disease Relevance 0 Pain Relevance 0.44
The excess axial current produced by the faster AP was strongly correlated with the distance gained by the faster AP over the slower AP—the winning margin (Figure 4E).
Gene_expression (produced) of AP in margin associated with action potential
17) Confidence 0.26 Published 2007 Journal PLoS Computational Biology Section Body Doc Link PMC1864994 Disease Relevance 0 Pain Relevance 0.37
Second, a novel mode of AP propagation (stochastic microsaltatory conduction), where the AP leaps ahead toward spontaneously formed clusters of open Na channels, produces random discrete jumps in spike time reliability.
Gene_expression (leaps) of AP in spike
18) Confidence 0.26 Published 2007 Journal PLoS Computational Biology Section Abstract Doc Link PMC1864994 Disease Relevance 0 Pain Relevance 0.17
Yet, in marked contrast to AP initiation, during AP propagation the ionic (Na and K) currents trail the early rising phase of the AP (in Figure 3C between ?
Gene_expression (propagation) of AP associated with action potential
19) Confidence 0.26 Published 2007 Journal PLoS Computational Biology Section Body Doc Link PMC1864994 Disease Relevance 0 Pain Relevance 0.46
The excess Na+ influx (measured in units of Na+ charge) produced under the early rising phase (red curve in Figure 4C) and the excess axial current (Figure 4B) in the faster AP correlated well with each other (red curve Figure 4F).
Gene_expression (produced) of AP associated with action potential
20) Confidence 0.26 Published 2007 Journal PLoS Computational Biology Section Body Doc Link PMC1864994 Disease Relevance 0 Pain Relevance 0.33

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