INT44784

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Context Info
Confidence 0.64
First Reported 1984
Last Reported 2010
Negated 0
Speculated 1
Reported most in Abstract
Documents 8
Total Number 9
Disease Relevance 9.75
Pain Relevance 1.74

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cell adhesion (NPHS1) plasma membrane (NPHS1) protein complex (NPHS1)
Anatomy Link Frequency
neuronal 2
diaphragm 2
podocytes 2
plasma 1
superior colliculus 1
NPHS1 (Homo sapiens)
Pain Link Frequency Relevance Heat
Central grey 2 98.66 Very High Very High Very High
Morphine 8 98.40 Very High Very High Very High
narcan 4 96.84 Very High Very High Very High
Pain 22 90.52 High High
antinociception 2 87.76 High High
Inflammation 47 82.88 Quite High
midbrain 2 78.68 Quite High
cytokine 25 69.68 Quite High
Inflammatory mediators 15 66.04 Quite High
Inflammatory response 5 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Sprains And Strains 31 99.36 Very High Very High Very High
Burns 370 98.76 Very High Very High Very High
Urological Neuroanatomy 2 98.66 Very High Very High Very High
Acute Renal Failure 415 98.48 Very High Very High Very High
Sepsis 130 96.32 Very High Very High Very High
Proteinuria 165 96.16 Very High Very High Very High
Disorders Of Creatine Metabolism 35 93.12 High High
Apoptosis 205 92.84 High High
Pain 16 90.52 High High
Cystitis 34 87.76 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Our results showed that: 1) the majority of neurons in the CnF displayed monophasic excitatory responses in the first or second phase after formalin injection, except a small portion of neurons which did not exhibit any responses; 2) unit activity of CnF neurons was suppressed after subcutaneous (sc) morphine administration and resumed by naloxone; 3) the increased neuronal firing induced by sc formalin could be suppressed by a single dose of sc morphine; and 4) the response patterns of many CnF neurons changed by preinjection of morphine during 2 phases of the formalin test.
Gene_expression (neurons) of CnF in neuronal associated with narcan and morphine
1) Confidence 0.64 Published 2010 Journal J Pain Section Abstract Doc Link 19632161 Disease Relevance 0.18 Pain Relevance 0.69
Our results showed that: 1) the majority of neurons in the CnF displayed monophasic excitatory responses in the first or second phase after formalin injection, except a small portion of neurons which did not exhibit any responses; 2) unit activity of CnF neurons was suppressed after subcutaneous (sc) morphine administration and resumed by naloxone; 3) the increased neuronal firing induced by sc formalin could be suppressed by a single dose of sc morphine; and 4) the response patterns of many CnF neurons changed by preinjection of morphine during 2 phases of the formalin test.
Gene_expression (neurons) of CnF in neuronal associated with narcan and morphine
2) Confidence 0.64 Published 2010 Journal J Pain Section Abstract Doc Link 19632161 Disease Relevance 0.22 Pain Relevance 0.68
We also observed a marked down-regulation of nephrin expression in cultured podocytes after exposure to burns septic ARF group plasma.
Gene_expression (expression) of nephrin in plasma associated with acute renal failure and burns
3) Confidence 0.36 Published 2008 Journal Crit Care Section Body Doc Link PMC2447585 Disease Relevance 1.20 Pain Relevance 0.06
Burns septic ARF group plasma altered polarity, cytoskeleton distribution, permeability and nephrin expression in podocytes
Gene_expression (expression) of nephrin in podocytes associated with acute renal failure and burns
4) Confidence 0.36 Published 2008 Journal Crit Care Section Body Doc Link PMC2447585 Disease Relevance 1.68 Pain Relevance 0
Projections to caudal CNF were observed from all subdivisions of the periaqueductal gray, the deep layers of the superior colliculus as well as the caudal levels of the CNF.
Gene_expression (levels) of CNF in superior colliculus associated with central grey
5) Confidence 0.28 Published 1984 Journal Neurosci. Lett. Section Abstract Doc Link 6527828 Disease Relevance 0.25 Pain Relevance 0.16
The expression of nephrin, a slit diaphragm protein, whose alteration is deeply involved in the pathogenic mechanisms of proteinuria, was also investigated.
Spec (investigated) Gene_expression (expression) of nephrin in diaphragm associated with proteinuria
6) Confidence 0.28 Published 2008 Journal Crit Care Section Body Doc Link PMC2447585 Disease Relevance 1.41 Pain Relevance 0
In podocytes, burns septic group plasma increased permeability to albumin and decreased the expression of the slit diaphragm protein nephrin.


Gene_expression (expression) of nephrin in podocytes associated with burns
7) Confidence 0.25 Published 2008 Journal Crit Care Section Body Doc Link PMC2447585 Disease Relevance 1.55 Pain Relevance 0.11
In podocytes, plasma from septic burns patients increased permeability to albumin and decreased the expression of the slit diaphragm protein nephrin.


Gene_expression (expression) of nephrin in diaphragm associated with burns
8) Confidence 0.25 Published 2008 Journal Crit Care Section Abstract Doc Link PMC2447585 Disease Relevance 2.31 Pain Relevance 0.04
Moreover, the expressions of cnf, and papEF significantly reduced the risk of ciprofloxacin resistance.
Gene_expression (expressions) of cnf
9) Confidence 0.02 Published 2010 Journal Journal of Korean Medical Science Section Abstract Doc Link PMC2844595 Disease Relevance 0.95 Pain Relevance 0

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