INT44789

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Context Info
Confidence 0.36
First Reported 1983
Last Reported 2010
Negated 1
Speculated 0
Reported most in Abstract
Documents 10
Total Number 11
Disease Relevance 1.65
Pain Relevance 4.01

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

plasma membrane (Sdcbp) cytoplasm (Sdcbp)
Anatomy Link Frequency
liver 2
plasma 1
hepatocytes 1
platelets 1
Sdcbp (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Paracetamol 188 99.78 Very High Very High Very High
aspirin 5 98.54 Very High Very High Very High
qutenza 9 96.52 Very High Very High Very High
ischemia 66 82.88 Quite High
Potency 2 62.64 Quite High
Central nervous system 2 37.20 Quite Low
anesthesia 4 9.60 Low Low
Inflammation 16 5.00 Very Low Very Low Very Low
cytokine 4 5.00 Very Low Very Low Very Low
Inflammatory mediators 3 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Hepatotoxicity 29 98.88 Very High Very High Very High
Stress 53 98.84 Very High Very High Very High
Hemolysis 1 84.88 Quite High
Cv Unclassified Under Development 49 82.88 Quite High
Injury 74 82.56 Quite High
Acidosis 4 82.24 Quite High
Decapitation 4 79.24 Quite High
Ocular Hypertension 10 72.88 Quite High
Leukemia 1 57.60 Quite High
Death 16 52.16 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
PC combination with ASA at therapeutic doses range (50.0 + 50.0 mg/kg) significantly diminished MDA formation, while at subtoxic doses range (250.0 + 250.0 mg/kg) such effect was not detected, although subsequent tendency toward CL intensity reduction was observed.
MDA Binding (formation) of associated with aspirin
1) Confidence 0.36 Published 1996 Journal Eksp Klin Farmakol Section Abstract Doc Link 8704633 Disease Relevance 0 Pain Relevance 0.25
The addition of perchloric acid was necessary to precipitate proteins and release the MDA bound to the amino groups of proteins and other amino compounds.
MDA Binding (bound) of
2) Confidence 0.11 Published 2010 Journal Clinical Ophthalmology (Auckland, N.Z.) Section Body Doc Link PMC2819765 Disease Relevance 0 Pain Relevance 0
TMZ has also been reported to reduce the tissue formation of MDA.26 It reduces the oxidative stress which occurs during the reoxygenation phase of the reperfusion, evaluated as a limited reduction in glutathione release.27
MDA Binding (formation) of associated with stress
3) Confidence 0.11 Published 2010 Journal Clinical Ophthalmology (Auckland, N.Z.) Section Body Doc Link PMC2819765 Disease Relevance 0.59 Pain Relevance 0.07
The assay is based on the ability of a chromogenic agent to react with MDA, yielding a stable chromophore with maximal absorbance at 586 nm.
MDA Binding (react) of
4) Confidence 0.06 Published 2010 Journal Scand J Trauma Resusc Emerg Med Section Body Doc Link PMC2913934 Disease Relevance 0 Pain Relevance 0
In isolated mouse liver cells paracetamol does not require preliminary cytochrome P-450 induction to stimulate MDA formation, even at concentrations ineffective in rat cells.
MDA Binding (formation) of in liver associated with paracetamol
5) Confidence 0.05 Published 1983 Journal Chem. Biol. Interact. Section Abstract Doc Link 6652811 Disease Relevance 0 Pain Relevance 0.65
In AA-stimulated platelets, MDA formation was slightly decreased and TXB2 formation was not affected.
MDA Binding (formation) of in platelets
6) Confidence 0.04 Published 1984 Journal Thromb. Res. Section Abstract Doc Link 6528310 Disease Relevance 0.08 Pain Relevance 0.68
TBA reacted with MDA to form thiobarbituric acid product which was measured at 532 nm according [23].
MDA Binding (reacted) of
7) Confidence 0.04 Published 2008 Journal The Open Cardiovascular Medicine Journal Section Body Doc Link PMC2570581 Disease Relevance 0.06 Pain Relevance 0
However, 5 mM paracetamol, despite a great depletion of cellular GSH content, does not promote MDA formation either in the rat or in the mouse hepatocytes.
MDA Neg (not) Binding (formation) of in hepatocytes associated with paracetamol
8) Confidence 0.04 Published 1983 Journal Chem. Biol. Interact. Section Abstract Doc Link 6652811 Disease Relevance 0 Pain Relevance 0.71
The extent of lipid peroxidation was expressed as nmol of (MDA) formed per 100 mg of protein.


MDA Binding (nmol) of
9) Confidence 0.03 Published 2010 Journal BMC Pharmacol Section Body Doc Link PMC2967507 Disease Relevance 0 Pain Relevance 0
By itself, APAP increased MDA formation and had a significant lowering influence on the levels of GSH and GSSG, the GSH/GSSH ratio, and the activities of GR, GST and GCS both in the plasma and liver.
MDA Binding (formation) of in plasma associated with paracetamol
10) Confidence 0.02 Published 2010 Journal J Biomed Sci Section Abstract Doc Link PMC2994383 Disease Relevance 0.46 Pain Relevance 0.83
By itself, APAP increased MDA formation and had a significant lowering influence on the levels of GSH and GSSG, the GSH/GSSH ratio, and the activities of GR, GST and GCS both in the plasma and liver.
MDA Binding (formation) of in liver associated with paracetamol
11) Confidence 0.01 Published 2010 Journal J Biomed Sci Section Abstract Doc Link PMC2994383 Disease Relevance 0.46 Pain Relevance 0.83

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