INT4479

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Context Info
Confidence 0.56
First Reported 1975
Last Reported 2010
Negated 0
Speculated 0
Reported most in Abstract
Documents 17
Total Number 17
Disease Relevance 6.10
Pain Relevance 3.27

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

peptidase activity (REN) extracellular space (REN) extracellular region (REN)
intracellular (REN) response to stress (REN)
Anatomy Link Frequency
plasma 12
RAO 4
liver 2
REN (Homo sapiens)
Pain Link Frequency Relevance Heat
opiate 6 99.98 Very High Very High Very High
Dopamine 5 99.84 Very High Very High Very High
narcan 7 98.60 Very High Very High Very High
Morphine 5 97.96 Very High Very High Very High
antagonist 4 97.68 Very High Very High Very High
Endogenous opioid 4 97.20 Very High Very High Very High
Clonidine 5 93.36 High High
peptic ulcer disease 15 92.72 High High
Neuronal nitric oxide synthase 1 92.56 High High
Serotonin 2 86.16 High High
Disease Link Frequency Relevance Heat
Increased Venous Pressure Under Development 8 100.00 Very High Very High Very High
Hypertension 46 99.90 Very High Very High Very High
Natriuresis 14 98.48 Very High Very High Very High
Fetal Distress 1 94.68 High High
Ulcers 14 94.00 High High
Intrauterine Growth Retardation 1 93.88 High High
Erythrocytosis 9 93.00 High High
Disease 24 92.72 High High
Pressure Volume 2 Under Development 5 91.68 High High
Disorders Of Creatine Metabolism 13 88.20 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Administration of propranolol (iv) or phentolamine directly into the renal artery totally blocked the increase in renin during activation of the reflex.
Negative_regulation (blocked) of Positive_regulation (increase) of renin in renal artery
1) Confidence 0.56 Published 1982 Journal Am. J. Physiol. Section Abstract Doc Link 7039357 Disease Relevance 0.24 Pain Relevance 0.12
Acute antagonism of endogenous opiates abolished the increase in plasma renin activity and mean arterial pressure associated with renal arterial constriction.
Negative_regulation (abolished) of Positive_regulation (increase) of plasma renin in plasma associated with opiate
2) Confidence 0.50 Published 1986 Journal Am. J. Physiol. Section Abstract Doc Link 3515972 Disease Relevance 0.08 Pain Relevance 0.74
When this increase occurs during treatment with ACEIs and ARBs, the result is increased levels of PRA but during treatment with aliskiren, the effect of increased renin levels is blocked, so the levels of Ang I and Ang II, as well as PRA, are all reduced.52 The clinical trials do not report any major adverse effects of aliskiren compared with ARBs or ACEs being generally well tolerated by all patients.
Negative_regulation (blocked) of Positive_regulation (increased) of renin
3) Confidence 0.48 Published 2010 Journal Vascular Health and Risk Management Section Body Doc Link PMC2922316 Disease Relevance 1.09 Pain Relevance 0.15
Indomethacin also suppressed the increase in renin secretion rate.
Negative_regulation (suppressed) of Positive_regulation (increase) of renin
4) Confidence 0.48 Published 1983 Journal Arch Int Pharmacodyn Ther Section Abstract Doc Link 6342558 Disease Relevance 0 Pain Relevance 0
The fetal hemodynamic parameters may be affected by captopril administration to the mother: blood pressure falls, plasma renin activity increases, ACE activity decreases.
Negative_regulation (decreases) of Positive_regulation (increases) of renin in plasma
5) Confidence 0.45 Published 1989 Journal Dev Pharmacol Ther Section Abstract Doc Link 2693003 Disease Relevance 0.19 Pain Relevance 0.36
The role of intrarenal dopaminergic receptors has been studied: (a) Haloperidol (intrarenal perfusion of 50 mug/kg/min for 20 min) suppresses the renal vasodilation and renin hypersecretion induced by dopamine.
Negative_regulation (suppresses) of Positive_regulation (induced) of renin associated with dopamine and increased venous pressure under development
6) Confidence 0.43 Published 1975 Journal Eur. J. Pharmacol. Section Abstract Doc Link 1175682 Disease Relevance 0.29 Pain Relevance 0.21
The renin release induced by 5-HT was suppressed during intrarenal arterial infusion of a 5-HT1 and 5-HT2 antagonist, methysergide (30 micrograms/kg per min), or a selective 5-HT2 antagonist, ketanserin (3 micrograms/kg per min).
Negative_regulation (suppressed) of Positive_regulation (induced) of renin associated with antagonist
7) Confidence 0.41 Published 1991 Journal Eur. J. Pharmacol. Section Abstract Doc Link 1905236 Disease Relevance 0 Pain Relevance 0.18
Indomethacin reduced base-line and diuretic-induced increase in plasma renin activity, plasma angiotensin II levels and urinary excretion of prostaglandin 6-keto F1 alpha to a similar extent under the two sodium diets.
Negative_regulation (reduced) of Positive_regulation (increase) of renin in plasma
8) Confidence 0.38 Published 1989 Journal J. Pharmacol. Exp. Ther. Section Abstract Doc Link 2703968 Disease Relevance 0.97 Pain Relevance 0.28
With time, the accumulated 125I-rh-renin in the liver and kidneys decreased.
Negative_regulation (decreased) of Positive_regulation (accumulated) of 125I-rh-renin in liver
9) Confidence 0.38 Published 1988 Journal Hypertension Section Abstract Doc Link 3049339 Disease Relevance 0 Pain Relevance 0
In chronic preparations long-term naloxone infusion attenuated the development of renovascular hypertension and diminished the increase in plasma renin activity.
Negative_regulation (diminished) of Positive_regulation (increase) of plasma renin in plasma associated with hypertension and narcan
10) Confidence 0.37 Published 1986 Journal Am. J. Physiol. Section Abstract Doc Link 3515972 Disease Relevance 0.10 Pain Relevance 0.71
The increase in renin release to high level RNS was equally reduced by 33% by 0.5 mg/kg and 2.0 mg/kg of metoprolol. dl-propranolol, 0.5 mg/kg, reduced the renin release response to about the same extent, 44%, while 2.0 mg/kg reduced it somewhat more, 59%.
Negative_regulation (reduced) of Positive_regulation (increase) of renin
11) Confidence 0.35 Published 1980 Journal Pflugers Arch. Section Abstract Doc Link 6107894 Disease Relevance 0 Pain Relevance 0.08
Indirectly, the diuretic action of HCTZ reduces plasma volume with consequent increases in plasma renin activity, aldosterone secretion and urinary potassium loss, and decreases in serum potassium (Reyes 2002).
Negative_regulation (reduces) of Positive_regulation (increases) of plasma renin in plasma
12) Confidence 0.18 Published 2006 Journal Vascular Health and Risk Management Section Body Doc Link PMC1994025 Disease Relevance 0.58 Pain Relevance 0
This occurred in the absence of elevated plasma renin activity.
Negative_regulation (absence) of Positive_regulation (elevated) of renin in plasma
13) Confidence 0.13 Published 1996 Journal Circulation Section Body Doc Link 8640982 Disease Relevance 0.06 Pain Relevance 0
Several reviews have concluded that renin is increased with short- to moderate-term lead exposure in both animals and humans but is normal or decreased with prolonged exposure (Gonick and Behari 2002; Sharp et al. 1987; Vander 1988).
Negative_regulation (decreased) of Positive_regulation (increased) of renin
14) Confidence 0.12 Published 2005 Journal Environ Health Perspect Section Body Doc Link PMC1253707 Disease Relevance 0.19 Pain Relevance 0.05
The elevation in renin secretion rate decreased between 30 and 122 min after the initiation of RAO in the pentobarbital-anesthetized dogs but not in the chloralose-urethan-anesthetized dogs.
Negative_regulation (decreased) of Positive_regulation (elevation) of renin in RAO
15) Confidence 0.12 Published 1975 Journal Am. J. Physiol. Section Abstract Doc Link 1211457 Disease Relevance 0 Pain Relevance 0.08
They suggested that the reparative functions of the mucous of the gastrointestinal track were influenced by a reduction of angiotensin II formation and activation of the renin-kallicrein-kinin system.
Negative_regulation (reduction) of Positive_regulation (activation) of renin-kallicrein-kinin
16) Confidence 0.01 Published 2008 Journal BMC Endocr Disord Section Body Doc Link PMC2632632 Disease Relevance 1.54 Pain Relevance 0.22
Inactivation of the renin-angiotensin system (RAS) by an angiotensin-converting enzyme (ACE) inhibitor, or an angiotensin II type 1 AT1 receptor blocker represents the most effective, safe, and well-tolerated therapeutic modality.
Negative_regulation (represents) of Positive_regulation (Inactivation) of renin-angiotensin system
17) Confidence 0.00 Published 2003 Journal Kidney Int. Section Abstract Doc Link 12631334 Disease Relevance 0.77 Pain Relevance 0.10

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