INT44796

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Context Info
Confidence 0.45
First Reported 1984
Last Reported 2007
Negated 1
Speculated 0
Reported most in Abstract
Documents 11
Total Number 11
Disease Relevance 5.25
Pain Relevance 2.90

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

signal transduction (Ptger1) plasma membrane (Ptger1) signal transducer activity (Ptger1)
Anatomy Link Frequency
PGE2 2
artery 1
afferent neurons 1
Ptger1 (Mus musculus)
Pain Link Frequency Relevance Heat
bradykinin 6 100.00 Very High Very High Very High
qutenza 52 99.76 Very High Very High Very High
IPN 8 99.14 Very High Very High Very High
Morphine 4 99.12 Very High Very High Very High
fortral 4 98.86 Very High Very High Very High
Inflammation 36 98.76 Very High Very High Very High
Thermal hyperalgesia 15 97.92 Very High Very High Very High
Analgesic 8 94.16 High High
adenocard 2 94.16 High High
cINOD 14 90.12 High High
Disease Link Frequency Relevance Heat
Hypertension 4 99.78 Very High Very High Very High
INFLAMMATION 48 98.76 Very High Very High Very High
Fever 13 98.12 Very High Very High Very High
Hyperalgesia 18 97.92 Very High Very High Very High
Malignant Neoplastic Disease 44 96.64 Very High Very High Very High
Targeted Disruption 25 91.32 High High
Cv General 2 Under Development 4 86.96 High High
Cancer 61 86.36 High High
Hypercalcemia 1 83.20 Quite High
Pain 11 81.04 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
PGE2 acts by interacting with four subtypes of PGE receptor, the EP1, EP2, EP3 and EP4 receptors.
PGE receptor Binding (interacting) of in PGE2
1) Confidence 0.45 Published 1998 Journal Nature Section Abstract Doc Link 9751056 Disease Relevance 0.84 Pain Relevance 0.22
PGE2 acts by interacting with four subtypes of PGE receptor, the EP1, EP2, EP3 and EP4 receptors.
EP1 Binding (interacting) of in PGE2
2) Confidence 0.35 Published 1998 Journal Nature Section Abstract Doc Link 9751056 Disease Relevance 0.84 Pain Relevance 0.22
The present findings confirmed a role for endogenous PGE2 produced by COX-1 in adaptive gastric cytoprotection and suggested that this action is mediated by activation of EP1-receptors but not associated with capsaicin-sensitive afferent neurons.
EP1 Binding (associated) of in afferent neurons associated with qutenza
3) Confidence 0.32 Published 2001 Journal J. Pharmacol. Exp. Ther. Section Abstract Doc Link 11356942 Disease Relevance 0.25 Pain Relevance 0.28
The data presented herein demonstrate that TRPV1 is essential for the development of thermal hyperalgesia in vivo induced by two major inflammation-associated prostaglandins, PGE2 and PGI2, and that TRPV1 and EP1 or IP receptors can functionally interact, mainly through a PKC-dependent pathway.
EP1 Binding (interact) of associated with inflammation and thermal hyperalgesia
4) Confidence 0.26 Published 2005 Journal Mol Pain Section Body Doc Link PMC1074353 Disease Relevance 0.72 Pain Relevance 0.51
The FP, TP, and EP1 receptors preferentially couple to increased cell Ca2+.
EP1 Binding (couple) of
5) Confidence 0.24 Published 2000 Journal Curr. Opin. Nephrol. Hypertens. Section Abstract Doc Link 10654821 Disease Relevance 0.20 Pain Relevance 0.09
FP, TP, and EP1 receptors preferentially couple to an increase in cell calcium.
EP1 Binding (couple) of
6) Confidence 0.24 Published 2001 Journal Annu. Rev. Physiol. Section Abstract Doc Link 11181968 Disease Relevance 0.14 Pain Relevance 0.04
The additional Mr species most likely represents phosphorylated forms of mPGES-1 and EP1–2.
EP1 Binding (forms) of
7) Confidence 0.16 Published 2006 Journal Mol Cancer Section Body Doc Link PMC1657027 Disease Relevance 1.06 Pain Relevance 0
Knockdown for EP1–4
EP1 Binding (Knockdown) of
8) Confidence 0.16 Published 2007 Journal Gene Regulation and Systems Biology Section Body Doc Link PMC2759147 Disease Relevance 1.09 Pain Relevance 0.28
AD-1211, as well as pentazocine and morphine, blocked the reflex hypertension caused by injection of both bradykinin and bradykinin plus PGE1 into the splenic artery of dogs.
PGE1 Binding (injection) of in artery associated with fortral, hypertension, bradykinin and morphine
9) Confidence 0.02 Published 1984 Journal Eur. J. Pharmacol. Section Abstract Doc Link 6529980 Disease Relevance 0.10 Pain Relevance 1.02
These results suggest that the sixth to seventh transmembrane domain of the mIP receptor confers the specificity of this receptor to bind selectively to PGE1 and not to PGE2 and that the third transmembrane domain of the mDP receptor confers the selective binding of PGD2 to this receptor.
PGE1 Binding (bind) of
10) Confidence 0.01 Published 1997 Journal J. Biol. Chem. Section Abstract Doc Link 9182536 Disease Relevance 0 Pain Relevance 0.06
This chimeric IPN-V/DPVI-C receptor acquired the ability to bind [3H]PGD2 and [3H]PGE2 without decreasing the affinities of the mIP receptor to [3H]iloprost and [3H]PGE1.
PGE1 Neg (without) Binding (bind) of associated with ipn
11) Confidence 0.01 Published 1997 Journal J. Biol. Chem. Section Abstract Doc Link 9182536 Disease Relevance 0 Pain Relevance 0.18

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