INT4480

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Context Info
Confidence 0.39
First Reported 1975
Last Reported 2005
Negated 1
Speculated 0
Reported most in Abstract
Documents 3
Total Number 3
Disease Relevance 0.53
Pain Relevance 1.30

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

lyase activity (Ddc) cellular amino acid metabolic process (Ddc) cytoplasm (Ddc)
Anatomy Link Frequency
cortex 1
Ddc (Mus musculus)
Pain Link Frequency Relevance Heat
Serotonin 23 99.92 Very High Very High Very High
midbrain 21 99.68 Very High Very High Very High
Dopamine 152 99.64 Very High Very High Very High
Calcitonin gene-related peptide 1 99.48 Very High Very High Very High
Clonidine 2 98.36 Very High Very High Very High
gABA 4 97.88 Very High Very High Very High
substance P 1 97.68 Very High Very High Very High
Somatostatin 2 94.92 High High
Neuropeptide 3 94.16 High High
Neurotransmitter 10 88.84 High High
Disease Link Frequency Relevance Heat
Attention Deficit Hyperactivity Disorder 163 96.84 Very High Very High Very High
Embryonal Carcinoma 2 78.44 Quite High
Sprains And Strains 3 57.72 Quite High
Hypertension 7 7.88 Low Low
Ocular Toxicity (including Many Sub-types) 11 5.00 Very Low Very Low Very Low
Cognitive Disorder 9 5.00 Very Low Very Low Very Low
Stress 5 5.00 Very Low Very Low Very Low
Hypoxia 4 5.00 Very Low Very Low Very Low
Targeted Disruption 3 5.00 Very Low Very Low Very Low
Anxiety Disorder 3 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
However, piribedil neither reduced nor increased the motor effects of apomorphine or L-DOPA in the reserpinised mouse, but slightly enhanced that of amphetamine.
Neg (neither) Positive_regulation (increased) of L-DOPA
1) Confidence 0.39 Published 1975 Journal Eur. J. Pharmacol. Section Abstract Doc Link 1175688 Disease Relevance 0 Pain Relevance 0.14
DOPA decarboxylase activity was found to be increased in the midbrain of children and decreased in prefrontal cortex of adults with ADHD compared to controls [52,53].
Positive_regulation (increased) of DOPA decarboxylase in cortex associated with midbrain and attention deficit hyperactivity disorder
2) Confidence 0.06 Published 2005 Journal Behav Brain Funct Section Body Doc Link PMC1180819 Disease Relevance 0.37 Pain Relevance 0.52
Smaller numbers of cells were positive for tyrosine hydroxylase, DOPA decarboxylase, serotonin, calcitonin gene-related peptide, galanin and substance P.
Positive_regulation (positive) of DOPA decarboxylase associated with serotonin, substance p and calcitonin gene-related peptide
3) Confidence 0.02 Published 1994 Journal Neuroscience Section Abstract Doc Link 7910670 Disease Relevance 0.15 Pain Relevance 0.64

General Comments

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