INT44816

From wiki-pain
Jump to: navigation, search
Context Info
Confidence 0.62
First Reported 1982
Last Reported 2008
Negated 6
Speculated 4
Reported most in Abstract
Documents 16
Total Number 20
Disease Relevance 3.63
Pain Relevance 8.02

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

transport (Serpina6) extracellular space (Serpina6) extracellular region (Serpina6)
molecular_function (Serpina6) cellular_component (Serpina6) biological_process (Serpina6)
Anatomy Link Frequency
blood 2
liver 2
plasma 1
heart 1
central nervous system 1
Serpina6 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Morphine 81 100.00 Very High Very High Very High
corticosteroid 49 100.00 Very High Very High Very High
Serotonin 8 100.00 Very High Very High Very High
iatrogenic 3 99.84 Very High Very High Very High
anesthesia 10 99.70 Very High Very High Very High
Central nervous system 14 99.68 Very High Very High Very High
Neurotransmitter 6 96.32 Very High Very High Very High
fluoxetine 4 90.80 High High
Opioid 1 89.52 High High
Inflammation 4 88.24 High High
Disease Link Frequency Relevance Heat
Stress 39 99.84 Very High Very High Very High
Hyperlipidemia 56 99.02 Very High Very High Very High
Adrenal Insufficiency 7 98.96 Very High Very High Very High
Disease 6 95.76 Very High Very High Very High
Hypothermia 1 91.52 High High
Frailty 12 88.96 High High
INFLAMMATION 4 88.24 High High
Syndrome 4 86.92 High High
Aging 2 84.96 Quite High
Myocardial Infarction 1 75.68 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Thus, studies were carried out to assess the effects of morphine on corticosteroid-binding globulin (CBG), the major glucocorticoid binder in blood.
Regulation (effects) of CBG in blood associated with corticosteroid and morphine
1) Confidence 0.62 Published 1997 Journal J. Pharmacol. Exp. Ther. Section Abstract Doc Link 9316834 Disease Relevance 0 Pain Relevance 0.53
Thus, studies were carried out to assess the effects of morphine on corticosteroid-binding globulin (CBG), the major glucocorticoid binder in blood.
Regulation (effects) of corticosteroid-binding globulin in blood associated with corticosteroid and morphine
2) Confidence 0.62 Published 1997 Journal J. Pharmacol. Exp. Ther. Section Abstract Doc Link 9316834 Disease Relevance 0 Pain Relevance 0.53
Closed heart surgery (closed mitral commissurotomy) resulted in an elevation of cortisol levels (up to 32 +/- 5 micrograms/dL by the end of the surgery) with no changes in CBG and ICC levels observed.
Neg (no) Regulation (changes) of CBG in heart
3) Confidence 0.52 Published 1996 Journal Steroids Section Abstract Doc Link 8837293 Disease Relevance 0.17 Pain Relevance 0.16
However, morphine did not significantly affect the weight of the liver, or the plasma CBG binding capacity for corticosterone, in rat pups.
Neg (not) Regulation (affect) of CBG in plasma associated with morphine
4) Confidence 0.29 Published 1998 Journal J. Neuroendocrinol. Section Abstract Doc Link 9663647 Disease Relevance 0.23 Pain Relevance 1.02
Moreover, as morphine is a hepatotoxic factor, we determined the effects of prenatal morphine on liver weight and plasma corticosteroid binding globulin (CBG) binding capacity in newborn rats.
Spec (determined) Regulation (effects) of CBG in liver associated with corticosteroid and morphine
5) Confidence 0.29 Published 1998 Journal J. Neuroendocrinol. Section Abstract Doc Link 9663647 Disease Relevance 0.14 Pain Relevance 0.77
Moreover, as morphine is a hepatotoxic factor, we determined the effects of prenatal morphine on liver weight and plasma corticosteroid binding globulin (CBG) binding capacity in newborn rats.
Spec (determined) Regulation (effects) of corticosteroid binding globulin in liver associated with corticosteroid and morphine
6) Confidence 0.29 Published 1998 Journal J. Neuroendocrinol. Section Abstract Doc Link 9663647 Disease Relevance 0.14 Pain Relevance 0.77
Stress-responsive changes in CBG levels seem to contribute little to changes in free B; the main contributing factor is the rise in total B.
Regulation (changes) of CBG associated with stress
7) Confidence 0.27 Published 1999 Journal Endocrine Section Abstract Doc Link 10709761 Disease Relevance 0.17 Pain Relevance 0.15
Since CBG-bound hormone is thought to be physiologically inactive, changes in CBG levels could affect corticosterone action independently of hormone levels per se.
Regulation (changes) of CBG
8) Confidence 0.27 Published 1997 Journal J. Pharmacol. Exp. Ther. Section Abstract Doc Link 9316834 Disease Relevance 0.05 Pain Relevance 0.56
In the study reported here, we found that in contrast to the effect in males, morphine has no apparent effect on CBG in females.
Neg (no) Regulation (effect) of CBG associated with morphine
9) Confidence 0.24 Published 1998 Journal J. Pharmacol. Exp. Ther. Section Abstract Doc Link 9694945 Disease Relevance 0 Pain Relevance 0.60
Ice bathing and cold exposure did not influence CBG, and water deprivation elevated serum CBG.
Neg (not) Regulation (influence) of CBG
10) Confidence 0.24 Published 1999 Journal Endocrine Section Abstract Doc Link 10709761 Disease Relevance 0.21 Pain Relevance 0.24
In contrast, anesthesia stress had no effect on serum and milk corticosteroid-binding globulin concentrations; the serum to milk ratio was approximately 10:1.
Neg (no) Regulation (effect) of corticosteroid-binding globulin associated with stress, corticosteroid and anesthesia
11) Confidence 0.24 Published 1984 Journal Endocrinology Section Abstract Doc Link 6541120 Disease Relevance 0.49 Pain Relevance 0.29
Salivary cortisol measurement was reported to have an equivalent diagnostic performance to serum cortisol and that is even better when CBG levels are altered.
Regulation (altered) of CBG
12) Confidence 0.21 Published 2008 Journal Ann. Endocrinol. (Paris) Section Abstract Doc Link 18954859 Disease Relevance 0.71 Pain Relevance 0.18
Short-term and long-term effects of p-chloroamphetamine on hippocampal serotonin and corticosteroid receptor levels.
Regulation (effects) of corticosteroid receptor associated with corticosteroid and serotonin
13) Confidence 0.19 Published 1995 Journal Brain Res. Section Title Doc Link 7583200 Disease Relevance 0 Pain Relevance 0.38
It is possible that the hyperlipidemia observed in the HF-HD and HF-LD rats might have altered the steroid-proteins [CBG & Pgp] interactions which in turn might have altered the availability of Dex.
Spec (might) Regulation (altered) of CBG associated with hyperlipidemia
14) Confidence 0.15 Published 2008 Journal Int Arch Med Section Body Doc Link PMC2414485 Disease Relevance 0.51 Pain Relevance 0.20
This review examines neurochemical mechanisms of the corticosteroid receptor regulation in the central nervous system.
Spec (examines) Regulation (regulation) of corticosteroid receptor in central nervous system associated with corticosteroid and central nervous system
15) Confidence 0.11 Published 1994 Journal Pol J Pharmacol Section Abstract Doc Link 8000453 Disease Relevance 0 Pain Relevance 0.28
The present set of studies examined the effect of para-chloroamphetamine (PCA) administration on both short-term and long-term regulation of hippocampal 5-HT and corticosteroid receptor levels.
Regulation (regulation) of corticosteroid receptor associated with corticosteroid
16) Confidence 0.08 Published 1995 Journal Brain Res. Section Abstract Doc Link 7583200 Disease Relevance 0 Pain Relevance 0.34
Dietary free fatty acids have been reported to alter the availability of glucocorticoids by modulating CBG [64].
Regulation (modulating) of CBG
17) Confidence 0.08 Published 2008 Journal Int Arch Med Section Body Doc Link PMC2414485 Disease Relevance 0.30 Pain Relevance 0.27
However, the effect of short-term manipulations of 5-HT levels on hippocampal corticosteroid receptor levels has not been thoroughly investigated.
Regulation (effect) of corticosteroid receptor associated with corticosteroid
18) Confidence 0.07 Published 1995 Journal Brain Res. Section Abstract Doc Link 7583200 Disease Relevance 0 Pain Relevance 0.30
In a final experiment, the long-term (7 days) effect of PCA administration on hippocampal 5-HT and corticosteroid receptor levels was examined.
Regulation (effect) of corticosteroid receptor associated with corticosteroid
19) Confidence 0.07 Published 1995 Journal Brain Res. Section Abstract Doc Link 7583200 Disease Relevance 0 Pain Relevance 0.33
SHBG levels were slightly suppressed, whereas F and CBG levels were unaffected.
Neg (unaffected) Regulation (unaffected) of CBG
20) Confidence 0.00 Published 1982 Journal Reproduccion Section Abstract Doc Link 6754512 Disease Relevance 0.52 Pain Relevance 0.13

General Comments

This test has worked.

Personal tools
Namespaces

Variants
Actions
Navigation
Toolbox