INT44816

Context Info Confidence 0.62 First Reported 1982 Last Reported 2008 Negated 6 Speculated 4 Reported most in Abstract Documents 16 Total Number 20 Disease Relevance 3.63 Pain Relevance 8.02

transport (Serpina6) extracellular space (Serpina6) extracellular region (Serpina6) molecular_function (Serpina6) cellular_component (Serpina6) biological_process (Serpina6)

Anatomy Link Frequency blood 2 liver 2 plasma 1 heart 1 central nervous system 1 Serpina6 (Rattus norvegicus)

Pain Link Frequency Relevance Heat Morphine 81 100.00 corticosteroid 49 100.00 Serotonin 8 100.00 iatrogenic 3 99.84 anesthesia 10 99.70 Central nervous system 14 99.68 Neurotransmitter 6 96.32 fluoxetine 4 90.80 Opioid 1 89.52 Inflammation 4 88.24

Disease Link Frequency Relevance Heat Stress 39 99.84 Hyperlipidemia 56 99.02 Adrenal Insufficiency 7 98.96 Disease 6 95.76 Hypothermia 1 91.52 Frailty 12 88.96 INFLAMMATION 4 88.24 Syndrome 4 86.92 Aging 2 84.96 Myocardial Infarction 1 75.68

Sentences Mentioned In

Key:

Protein

Mutation

Event

Anatomy

Negation

Speculation

Pain term

Disease term

Thus, studies were carried out to assess the effects of morphine on corticosteroid-binding globulin (CBG), the major glucocorticoid binder in blood.

Regulation (effects) of CBG in blood associated with corticosteroid and morphine

1) Confidence 0.62 Published 1997 Journal J. Pharmacol. Exp. Ther. Section Abstract Doc Link 9316834 Disease Relevance 0 Pain Relevance 0.53

Thus, studies were carried out to assess the effects of morphine on corticosteroid-binding globulin (CBG), the major glucocorticoid binder in blood.

Regulation (effects) of corticosteroid-binding globulin in blood associated with corticosteroid and morphine

2) Confidence 0.62 Published 1997 Journal J. Pharmacol. Exp. Ther. Section Abstract Doc Link 9316834 Disease Relevance 0 Pain Relevance 0.53

Closed heart surgery (closed mitral commissurotomy) resulted in an elevation of cortisol levels (up to 32 +/- 5 micrograms/dL by the end of the surgery) with no changes in CBG and ICC levels observed.

Neg (no) Regulation (changes) of CBG in heart

3) Confidence 0.52 Published 1996 Journal Steroids Section Abstract Doc Link 8837293 Disease Relevance 0.17 Pain Relevance 0.16

However, morphine did not significantly affect the weight of the liver, or the plasma CBG binding capacity for corticosterone, in rat pups.

Neg (not) Regulation (affect) of CBG in plasma associated with morphine

4) Confidence 0.29 Published 1998 Journal J. Neuroendocrinol. Section Abstract Doc Link 9663647 Disease Relevance 0.23 Pain Relevance 1.02

Moreover, as morphine is a hepatotoxic factor, we determined the effects of prenatal morphine on liver weight and plasma corticosteroid binding globulin (CBG) binding capacity in newborn rats.

Spec (determined) Regulation (effects) of CBG in liver associated with corticosteroid and morphine

5) Confidence 0.29 Published 1998 Journal J. Neuroendocrinol. Section Abstract Doc Link 9663647 Disease Relevance 0.14 Pain Relevance 0.77

Moreover, as morphine is a hepatotoxic factor, we determined the effects of prenatal morphine on liver weight and plasma corticosteroid binding globulin (CBG) binding capacity in newborn rats.

Spec (determined) Regulation (effects) of corticosteroid binding globulin in liver associated with corticosteroid and morphine

6) Confidence 0.29 Published 1998 Journal J. Neuroendocrinol. Section Abstract Doc Link 9663647 Disease Relevance 0.14 Pain Relevance 0.77

Stress-responsive changes in CBG levels seem to contribute little to changes in free B; the main contributing factor is the rise in total B.

Regulation (changes) of CBG associated with stress

7) Confidence 0.27 Published 1999 Journal Endocrine Section Abstract Doc Link 10709761 Disease Relevance 0.17 Pain Relevance 0.15

Since CBG-bound hormone is thought to be physiologically inactive, changes in CBG levels could affect corticosterone action independently of hormone levels per se.

Regulation (changes) of CBG

8) Confidence 0.27 Published 1997 Journal J. Pharmacol. Exp. Ther. Section Abstract Doc Link 9316834 Disease Relevance 0.05 Pain Relevance 0.56

In the study reported here, we found that in contrast to the effect in males, morphine has no apparent effect on CBG in females.

Neg (no) Regulation (effect) of CBG associated with morphine

9) Confidence 0.24 Published 1998 Journal J. Pharmacol. Exp. Ther. Section Abstract Doc Link 9694945 Disease Relevance 0 Pain Relevance 0.60

Ice bathing and cold exposure did not influence CBG, and water deprivation elevated serum CBG.

Neg (not) Regulation (influence) of CBG

10) Confidence 0.24 Published 1999 Journal Endocrine Section Abstract Doc Link 10709761 Disease Relevance 0.21 Pain Relevance 0.24

In contrast, anesthesia stress had no effect on serum and milk corticosteroid-binding globulin concentrations; the serum to milk ratio was approximately 10:1.

Neg (no) Regulation (effect) of corticosteroid-binding globulin associated with stress, corticosteroid and anesthesia

11) Confidence 0.24 Published 1984 Journal Endocrinology Section Abstract Doc Link 6541120 Disease Relevance 0.49 Pain Relevance 0.29

Salivary cortisol measurement was reported to have an equivalent diagnostic performance to serum cortisol and that is even better when CBG levels are altered.

Regulation (altered) of CBG

12) Confidence 0.21 Published 2008 Journal Ann. Endocrinol. (Paris) Section Abstract Doc Link 18954859 Disease Relevance 0.71 Pain Relevance 0.18

Short-term and long-term effects of p-chloroamphetamine on hippocampal serotonin and corticosteroid receptor levels.

Regulation (effects) of corticosteroid receptor associated with corticosteroid and serotonin

13) Confidence 0.19 Published 1995 Journal Brain Res. Section Title Doc Link 7583200 Disease Relevance 0 Pain Relevance 0.38

It is possible that the hyperlipidemia observed in the HF-HD and HF-LD rats might have altered the steroid-proteins [CBG & Pgp] interactions which in turn might have altered the availability of Dex.

Spec (might) Regulation (altered) of CBG associated with hyperlipidemia

14) Confidence 0.15 Published 2008 Journal Int Arch Med Section Body Doc Link PMC2414485 Disease Relevance 0.51 Pain Relevance 0.20

This review examines neurochemical mechanisms of the corticosteroid receptor regulation in the central nervous system.

Spec (examines) Regulation (regulation) of corticosteroid receptor in central nervous system associated with corticosteroid and central nervous system

15) Confidence 0.11 Published 1994 Journal Pol J Pharmacol Section Abstract Doc Link 8000453 Disease Relevance 0 Pain Relevance 0.28

The present set of studies examined the effect of para-chloroamphetamine (PCA) administration on both short-term and long-term regulation of hippocampal 5-HT and corticosteroid receptor levels.

Regulation (regulation) of corticosteroid receptor associated with corticosteroid

16) Confidence 0.08 Published 1995 Journal Brain Res. Section Abstract Doc Link 7583200 Disease Relevance 0 Pain Relevance 0.34

Dietary free fatty acids have been reported to alter the availability of glucocorticoids by modulating CBG [64].

Regulation (modulating) of CBG

17) Confidence 0.08 Published 2008 Journal Int Arch Med Section Body Doc Link PMC2414485 Disease Relevance 0.30 Pain Relevance 0.27

However, the effect of short-term manipulations of 5-HT levels on hippocampal corticosteroid receptor levels has not been thoroughly investigated.

Regulation (effect) of corticosteroid receptor associated with corticosteroid

18) Confidence 0.07 Published 1995 Journal Brain Res. Section Abstract Doc Link 7583200 Disease Relevance 0 Pain Relevance 0.30

In a final experiment, the long-term (7 days) effect of PCA administration on hippocampal 5-HT and corticosteroid receptor levels was examined.

Regulation (effect) of corticosteroid receptor associated with corticosteroid

19) Confidence 0.07 Published 1995 Journal Brain Res. Section Abstract Doc Link 7583200 Disease Relevance 0 Pain Relevance 0.33

SHBG levels were slightly suppressed, whereas F and CBG levels were unaffected.

Neg (unaffected) Regulation (unaffected) of CBG

20) Confidence 0.00 Published 1982 Journal Reproduccion Section Abstract Doc Link 6754512 Disease Relevance 0.52 Pain Relevance 0.13

General Comments

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