INT44817

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Context Info
Confidence 0.34
First Reported 1984
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 9
Total Number 10
Disease Relevance 9.84
Pain Relevance 1.11

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (Shbg) extracellular region (Shbg)
Anatomy Link Frequency
blood 6
liver 2
Shbg (Rattus norvegicus)
Pain Link Frequency Relevance Heat
opiate 4 98.40 Very High Very High Very High
antagonist 16 98.12 Very High Very High Very High
narcan 5 89.08 High High
Clonidine 2 74.24 Quite High
Endogenous opioid 1 71.08 Quite High
anesthesia 8 68.56 Quite High
depression 5 62.68 Quite High
ischemia 18 57.28 Quite High
Inflammation 3 55.24 Quite High
Eae 24 39.64 Quite Low
Disease Link Frequency Relevance Heat
Peritonitis 80 100.00 Very High Very High Very High
Pressure And Volume Under Development 178 99.92 Very High Very High Very High
Obesity 19 99.60 Very High Very High Very High
Hypertension 147 99.12 Very High Very High Very High
Endometriosis (extended) 13 98.12 Very High Very High Very High
Syndrome 7 96.80 Very High Very High Very High
Depression 8 95.44 Very High Very High Very High
Anxiety Disorder 85 94.84 High High
Hirsutism 31 94.36 High High
Hyperlipidemia 7 89.20 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Nevertheless, recent studies tend to demonstrate that SBP incidence seems to be decreasing (Sette et al 1986).
Negative_regulation (decreasing) of Gene_expression (incidence) of SBP associated with peritonitis
1) Confidence 0.34 Published 2008 Journal Therapeutics and Clinical Risk Management Section Body Doc Link PMC2621420 Disease Relevance 1.50 Pain Relevance 0.03
Insulin suppresses the production of SHBG by the liver.
Negative_regulation (suppresses) of Gene_expression (production) of SHBG in liver
2) Confidence 0.20 Published 2004 Journal Evidence-based Complementary and Alternative Medicine Section Body Doc Link PMC538507 Disease Relevance 0.23 Pain Relevance 0
The levels of estrone and androgens are higher in obese women along with a reduction in the levels of sex hormone binding globulin ( SHBG ).
Negative_regulation (reduction) of Gene_expression (levels) of SHBG associated with obesity
3) Confidence 0.19 Published 1993 Journal Prog Food Nutr Sci Section Abstract Doc Link 8372228 Disease Relevance 0.66 Pain Relevance 0.11
APH has been observed within 2 hours after surgery in most cases.10 Postoperative hypertension is defined as a systolic blood pressure (SBP) >190 mmHg and/or diastolic blood pressure (DBP) >100 mmHg on 2 consecutive readings after surgery.11
Negative_regulation (defined) of Gene_expression (pressure) of SBP in blood associated with pressure and volume under development
4) Confidence 0.17 Published 2010 Journal Vascular Health and Risk Management Section Body Doc Link PMC2922306 Disease Relevance 2.21 Pain Relevance 0.16
APH has been observed within 2 hours after surgery in most cases.10 Postoperative hypertension is defined as a systolic blood pressure (SBP) >190 mmHg and/or diastolic blood pressure (DBP) >100 mmHg on 2 consecutive readings after surgery.11
Negative_regulation (pressure) of Gene_expression (pressure) of SBP in blood associated with pressure and volume under development
5) Confidence 0.17 Published 2010 Journal Vascular Health and Risk Management Section Body Doc Link PMC2922306 Disease Relevance 2.27 Pain Relevance 0.16
A representative tracing of SBP observed in a single hypertensive patient during an exercise set is shown in Figure 1.
Negative_regulation (tracing) of Gene_expression (representative) of SBP associated with hypertension
6) Confidence 0.17 Published 2010 Journal Clinics (Sao Paulo) Section Body Doc Link PMC2845767 Disease Relevance 0.27 Pain Relevance 0
reducing gonadotropin secretion and thereby reducing ovarian androgen production.[18]increasing levels of SHBG resulting in lower levels of free testosterone.inhibiting adrenal androgen production.[19]

Androgen receptor blockers

Negative_regulation (reducing) of Gene_expression (levels) of SHBG
7) Confidence 0.09 Published 2010 Journal Indian Journal of Dermatology Section Body Doc Link PMC2856356 Disease Relevance 0.71 Pain Relevance 0
Decreased blood levels of sex hormone are thought to be involved in disorders after menopause [1], as postmenopausal syndrome is significantly improved by hormone replacement therapy, especially by a combined estrogen-progesterone regimen [2].
Negative_regulation (Decreased) of Gene_expression (levels) of sex hormone in blood associated with endometriosis (extended) and syndrome
8) Confidence 0.06 Published 2007 Journal Ann Gen Psychiatry Section Body Doc Link PMC1971263 Disease Relevance 1.37 Pain Relevance 0.03
Patients not normalized at week 4 by CC 8 mg, and in whom the dose of CC was increased to 16 mg, showed a decrease in their SBP/DBP values of ?
Negative_regulation (decrease) of Gene_expression (values) of SBP
9) Confidence 0.06 Published 2006 Journal Vascular Health and Risk Management Section Body Doc Link PMC1993978 Disease Relevance 0.61 Pain Relevance 0
Hemicastration reduced rABP synthesis and secretion; however, treatment with opiate antagonists did not alter the amount of this protein in the serum or epididymides of these rats.
Negative_regulation (reduced) of Gene_expression (synthesis) of rABP associated with antagonist and opiate
10) Confidence 0.02 Published 1984 Journal Endocrinology Section Abstract Doc Link 6541122 Disease Relevance 0 Pain Relevance 0.61

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