INT44818

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Context Info
Confidence 0.53
First Reported 1984
Last Reported 2009
Negated 0
Speculated 0
Reported most in Body
Documents 6
Total Number 6
Disease Relevance 2.29
Pain Relevance 1.05

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (Shbg) extracellular region (Shbg)
Anatomy Link Frequency
inferior 4
blood 2
central nervous system 2
Shbg (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Central nervous system 8 99.78 Very High Very High Very High
opiate 4 98.96 Very High Very High Very High
antagonist 25 98.68 Very High Very High Very High
Dismenorea 2 93.88 High High
Pain 2 93.88 High High
narcan 3 89.08 High High
headache 6 81.40 Quite High
withdrawal 2 79.04 Quite High
Endogenous opioid 2 71.08 Quite High
Paracetamol 2 23.04 Low Low
Disease Link Frequency Relevance Heat
Fibrocystic Breast Disease 1 97.32 Very High Very High Very High
Breast Cancer 4 96.92 Very High Very High Very High
Reprotox - General 3 13 94.32 High High
Reprotox - General 1 2 93.88 High High
Pain 2 93.88 High High
Endometriosis (extended) 14 88.24 High High
Diabetes Mellitus 54 82.44 Quite High
Reprotox - General 2 3 82.24 Quite High
Headache 7 81.40 Quite High
Sleep Disorders 3 81.00 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Because of their ability to suppress sex hormone secretion and the supposed role of these hormones in the physiopathology of fibrocystic mastopathy, GNRHAs have been proposed for the management of severe breast pain and nodularity.
Negative_regulation (suppress) of Localization (secretion) of sex hormone associated with pain and fibrocystic breast disease
1) Confidence 0.53 Published 1994 Journal Eur. J. Gynaecol. Oncol. Section Abstract Doc Link 8005138 Disease Relevance 0.70 Pain Relevance 0.17
The unaltered intratesticular T production contrasted with significantly lowered serum T concentration may reflect a reduction in sex hormone binding globulin (SHBG) essential for T transportation in blood [46].
Negative_regulation (reduction) of Localization (globulin) of sex hormone in blood
2) Confidence 0.38 Published 2009 Journal PPAR Research Section Body Doc Link PMC2696180 Disease Relevance 0.60 Pain Relevance 0
These effects may depend on both estrogenic and androgenic actions exerted at the genital level and in the central nervous system, and on a reduction of sex-hormone-binding globulin and an increase of free testosterone, without affecting ?
Negative_regulation (reduction) of Localization (increase) of sex-hormone-binding globulin in central nervous system associated with central nervous system
3) Confidence 0.27 Published 2006 Journal Neuropsychiatric Disease and Treatment Section Abstract Doc Link PMC2671819 Disease Relevance 0.87 Pain Relevance 0.26
Different primary end points were defined in these studies: the reduction in DBP, either from baseline (Karlberg et al 1999; Lacourciére et al 2001; McGill and Reilly 2001b; Lacourciére and Martin 2002; Freytag et al 2002) or to values inferior to 90 mmHg (Neutel et al 2002; Freytag et al 2002); changes in ambulatory DBP and SBP (Lacourciére et al 2003); and decreases in supine SBP (Karlberg et al 1999; Freytag et al 2001).
Negative_regulation (reduction) of Localization (decreases) of SBP in inferior
4) Confidence 0.09 Published 2007 Journal Vascular Health and Risk Management Section Body Doc Link PMC2293961 Disease Relevance 0.06 Pain Relevance 0
Different primary end points were defined in these studies: the reduction in DBP, either from baseline (Karlberg et al 1999; Lacourciére et al 2001; McGill and Reilly 2001b; Lacourciére and Martin 2002; Freytag et al 2002) or to values inferior to 90 mmHg (Neutel et al 2002; Freytag et al 2002); changes in ambulatory DBP and SBP (Lacourciére et al 2003); and decreases in supine SBP (Karlberg et al 1999; Freytag et al 2001).
Negative_regulation (reduction) of Localization (decreases) of SBP in inferior
5) Confidence 0.09 Published 2007 Journal Vascular Health and Risk Management Section Body Doc Link PMC2293961 Disease Relevance 0.06 Pain Relevance 0
Hemicastration reduced rABP synthesis and secretion; however, treatment with opiate antagonists did not alter the amount of this protein in the serum or epididymides of these rats.
Negative_regulation (reduced) of Localization (secretion) of rABP associated with antagonist and opiate
6) Confidence 0.01 Published 1984 Journal Endocrinology Section Abstract Doc Link 6541122 Disease Relevance 0 Pain Relevance 0.62

General Comments

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