INT44824

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Context Info
Confidence 0.50
First Reported 1980
Last Reported 2010
Negated 0
Speculated 0
Reported most in Abstract
Documents 10
Total Number 10
Disease Relevance 2.31
Pain Relevance 6.03

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

intracellular (Sp5)
Anatomy Link Frequency
neurons 3
Sp5C 2
MBH 1
lateral 1
Pr5 1
Sp5 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
fifth nerve 13 100.00 Very High Very High Very High
Raphe 10 100.00 Very High Very High Very High
Abeta 1 100.00 Very High Very High Very High
Glutamate receptor 3 99.80 Very High Very High Very High
anesthesia 4 99.16 Very High Very High Very High
c fibre 7 99.08 Very High Very High Very High
substantia gelatinosa 2 98.60 Very High Very High Very High
halothane 2 98.20 Very High Very High Very High
Rostral ventrolateral medulla 1 97.36 Very High Very High Very High
medulla 10 96.68 Very High Very High Very High
Disease Link Frequency Relevance Heat
Nociception 14 92.04 High High
Pain 36 90.24 High High
Arthritis 10 89.04 High High
Sleep Disorders 3 87.72 High High
Depression 2 85.40 High High
Toxocariasis 1 81.16 Quite High
Nervous System Injury 27 78.28 Quite High
Temporomandibular Joint Syndrome 4 75.00 Quite High
Morphine Dependence 1 74.28 Quite High
Hyperalgesia 4 73.28 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The mechanisms that underlie the activation of Sp5O convergent neurons by C-fibers and the inhibition of C-fiber-evoked responses of Sp5O convergent neurons by morphine microinjected into the Sp5C are discussed.
Positive_regulation (activation) of Sp5O in neurons associated with c fibre and morphine
1) Confidence 0.50 Published 1998 Journal J. Neurosci. Section Abstract Doc Link 9570784 Disease Relevance 0.23 Pain Relevance 1.38
Evidence also suggests that N-methyl-D-aspartate (NMDA) and non-NMDA glutamate receptors are both required for synaptic neurotransmission within Sp5I.
Positive_regulation (required) of Sp5I associated with glutamate receptor
2) Confidence 0.44 Published 1995 Journal Am. J. Physiol. Section Abstract Doc Link 7573570 Disease Relevance 0.25 Pain Relevance 0.27
Strychnine significantly increased the Abeta-fiber-evoked activities of Sp5O neurons to electrical stimulation in a dose-dependent (0.2-0.8 mg/kg) fashion.
Positive_regulation (increased) of Sp5O in neurons associated with abeta
3) Confidence 0.32 Published 2001 Journal J. Neurophysiol. Section Abstract Doc Link 11731563 Disease Relevance 0.15 Pain Relevance 0.21
The MBH neurons exhibited a high percentage of convergence to Ac, DR, SpV, ML and RLM stimulation.
Positive_regulation (stimulation) of SpV in MBH associated with fifth nerve and raphe
4) Confidence 0.27 Published 1984 Journal Int. J. Neurosci. Section Abstract Doc Link 6541213 Disease Relevance 0.07 Pain Relevance 1.70
Stimulation of either the DR or SpV evoked significant changes in firing rates of PFN units.
Positive_regulation (Stimulation) of SpV in SpV associated with fifth nerve and raphe
5) Confidence 0.17 Published 1980 Journal Brain Res. Section Abstract Doc Link 7407572 Disease Relevance 0 Pain Relevance 0.57
No expression of inducible nitric oxide synthase (iNOS) was detected in the Sp5C by either immunohistochemistry or reverse-transcription polymerase chain reaction (RT-PCR).
Positive_regulation (detected) of Sp5C in Sp5C
6) Confidence 0.16 Published 2009 Journal Brain Res. Section Abstract Doc Link 19769951 Disease Relevance 0.87 Pain Relevance 0.70
Electrical EN5 stimulation induced Fos expression in the Sp5C at the level of the area postrema and caudally in the upper cervical cord.
Positive_regulation (induced) of Sp5C in Sp5C
7) Confidence 0.15 Published 1997 Journal Exp Brain Res Section Abstract Doc Link 9386008 Disease Relevance 0 Pain Relevance 0.13
Cell counts revealed that nasal stimulation, compared to anesthesia controls, resulted in highly significant increases (p < or = 0.001) of Fos-immunoreactive (-ir) neurons in the midlevel KF, the external lateral PB, and the Sp5C.
Positive_regulation (increases) of Sp5C in lateral associated with anesthesia
8) Confidence 0.07 Published 1998 Journal Brain Res. Section Abstract Doc Link 9853114 Disease Relevance 0.08 Pain Relevance 0.30
Specimens of the experimental IDLE demonstrated a significant increase of TRPV4 activity in particular in stratum basale of conical papillae (p < 0.01). pERK-IR positive neurons were significantly increased in the RMg (p < 0.05), Sp5C (p < 0.05) and Md (p < 0.01); TRPV4-IR neurons were found to show a similar distribution with pERK-IR cells in the peripheral Sp5C (p < 0.05).
Positive_regulation (increased) of Sp5C in neurons
9) Confidence 0.04 Published 2009 Journal Okajimas Folia Anat Jpn Section Abstract Doc Link 19877445 Disease Relevance 0.46 Pain Relevance 0.55
In nerve injured animals, Iba-1 staining was significantly increased in the trigeminal nuclear complex, especially in the principal sensory nucleus (Pr5) and subnucleus caudalis (Sp5C) area (Figure 2).
Positive_regulation (increased) of Sp5C in Pr5
10) Confidence 0.03 Published 2010 Journal Mol Pain Section Body Doc Link PMC2992508 Disease Relevance 0.19 Pain Relevance 0.23

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