INT4485

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Context Info
Confidence 0.43
First Reported 1975
Last Reported 2010
Negated 0
Speculated 1
Reported most in Abstract
Documents 11
Total Number 12
Disease Relevance 4.24
Pain Relevance 3.89

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cell proliferation (PRL) cytosol (PRL) extracellular region (PRL)
Anatomy Link Frequency
plasma 4
thyroid 2
PRL (Homo sapiens)
Pain Link Frequency Relevance Heat
Serotonin 64 100.00 Very High Very High Very High
Morphine 18 100.00 Very High Very High Very High
Dynorphin 11 100.00 Very High Very High Very High
antagonist 43 99.96 Very High Very High Very High
agonist 50 99.74 Very High Very High Very High
Kappa opioid receptor 3 99.62 Very High Very High Very High
opiate 14 99.58 Very High Very High Very High
narcan 7 99.32 Very High Very High Very High
Buprenorphine 6 99.26 Very High Very High Very High
Endep 10 98.76 Very High Very High Very High
Disease Link Frequency Relevance Heat
Reprotox - General 3 13 99.96 Very High Very High Very High
Stress 15 99.50 Very High Very High Very High
Reprotox - General 1 68 98.84 Very High Very High Very High
Hypoactive Sexual Desire Disorder 2 96.36 Very High Very High Very High
Cancer 20 95.28 Very High Very High Very High
Galactorrhea 263 92.20 High High
Alcohol Addiction 1 88.84 High High
Depression 23 87.52 High High
Gynecomastia 15 87.04 High High
Anxiety Disorder 12 86.56 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Since the LOD and control group were in the same condition concerning the surgical and anesthesiologic stress, and the post-operation elevated PRL level was supposed to decrease after one week, the elevated PRL levels 6–10 weeks after operation in LOD group may be due to other cause than surgical or anesthesiologic stress.
Negative_regulation (decrease) of Positive_regulation (elevated) of PRL associated with stress
1) Confidence 0.43 Published 2005 Journal Reprod Biol Endocrinol Section Body Doc Link PMC1188073 Disease Relevance 0.71 Pain Relevance 0.15
Prolactin increase may further inhibit libido.
Spec (may) Negative_regulation (inhibit) of Positive_regulation (increase) of Prolactin associated with reprotox - general 3
2) Confidence 0.43 Published 2000 Journal Maturitas Section Abstract Doc Link 10759059 Disease Relevance 1.14 Pain Relevance 0.19
The abolishment of prolactin response to clomipramine after pre-treatment with serotonin receptor blockers clozapine and olanzapine (Markianos et al 2002) and its enhancement after L-tryptophan (Anderson and Cowen 1986) confirm the involvement of serotoninergic pathway in clomipramine-induced prolactin increase.
Negative_regulation (abolishment) of Positive_regulation (increase) of prolactin associated with serotonin
3) Confidence 0.43 Published 2007 Journal Therapeutics and Clinical Risk Management Section Body Doc Link PMC2376090 Disease Relevance 0.21 Pain Relevance 0.37
Accordingly, only monitoring of prolactin levels within the first 24 hours after oral administration of atypical antipsychotics may reveal early modifications: prolactin serum concentration increases within the first six hours after drug administration (up to two-fold from basal level) with a variable mean peak time, also in relation to the specific drug (120 min for risperidone, 180 min for clozapine and 290 min for olanzapine), and return to baseline values within 12–24 hours.
Negative_regulation (monitoring) of Positive_regulation (increases) of prolactin
4) Confidence 0.43 Published 2007 Journal Therapeutics and Clinical Risk Management Section Body Doc Link PMC2376090 Disease Relevance 0.18 Pain Relevance 0.37
It is suggested that the effect on prolactin is not mediated via non specific stress or changes in the thyroid stimulating hormone releasing factor, but via suppression prolactin inhibiting factor or activation of a specific prolactin releasing factor.
Negative_regulation (suppression) of Positive_regulation (activation) of prolactin in thyroid associated with stress
5) Confidence 0.42 Published 1975 Journal J. Clin. Endocrinol. Metab. Section Abstract Doc Link 1176587 Disease Relevance 0.10 Pain Relevance 0.25
Apomorphine prevented the morphine induced prolactin rise.
Negative_regulation (prevented) of Positive_regulation (induced) of prolactin associated with morphine
6) Confidence 0.42 Published 1975 Journal J. Clin. Endocrinol. Metab. Section Abstract Doc Link 1176587 Disease Relevance 0.09 Pain Relevance 0.27
Pretreatment with the opioid antagonist nalmefene (30 mg i.v.), which has high affinity at both mu- and kappa-opioid receptors, caused a greater attenuation in dynorphin A1-13-stimulated increases in serum prolactin levels than pretreatment with similarly high doses of naloxone, an antagonist with lower affinity for both mu- and kappa-opioid receptors.
Negative_regulation (attenuation) of Positive_regulation (increases) of prolactin associated with dynorphin, antagonist, narcan, kappa opioid receptor and opioid
7) Confidence 0.42 Published 1999 Journal J. Pharmacol. Exp. Ther. Section Abstract Doc Link 9862779 Disease Relevance 0.09 Pain Relevance 1.07
Naloxone alone had no hormonal effect but abolished the increase in PRL and GH following injection of FK 33-824 without modifying the decrease in plasma cortisol or the increase in free water clearance following the same treatment.
Negative_regulation (abolished) of Positive_regulation (increase) of PRL in plasma associated with narcan
8) Confidence 0.41 Published 1980 Journal Horm. Res. Section Abstract Doc Link 6262206 Disease Relevance 0 Pain Relevance 0.28
Buprenorphine, a mixed opiate agonist-antagonist, suppressed plasma luteinizing hormone (LH) and increased prolactin levels after 12 consecutive days of ascending dose administration (0.5-8 mg/day s.c.) in comparison to drug-free control conditions.
Negative_regulation (suppressed) of Positive_regulation (increased) of prolactin in plasma associated with antagonist, agonist, opiate and buprenorphine
9) Confidence 0.36 Published 1982 Journal J. Pharmacol. Exp. Ther. Section Abstract Doc Link 7057390 Disease Relevance 0 Pain Relevance 0.77
Elevations from baseline prolactin levels were observed at Day 15, and subsequently decreased but not to within normal range by the end point (Table 4) (Marder et al 2007).
Negative_regulation (decreased) of Positive_regulation (Elevations) of prolactin
10) Confidence 0.28 Published 2007 Journal Neuropsychiatric Disease and Treatment Section Body Doc Link PMC2656329 Disease Relevance 0.78 Pain Relevance 0
By January 2007, and with a continuation of cabergoline doses that suppressed prolactin increases, the IGF-1 levels of our patient had increased to 338 ng/ml.
Negative_regulation (suppressed) of Positive_regulation (increases) of prolactin
11) Confidence 0.16 Published 2010 Journal J Med Case Reports Section Body Doc Link PMC2845144 Disease Relevance 0.36 Pain Relevance 0.17
For example, atrazine delays puberty in both males and females, reducing circulating LH and prolactin [64].
Negative_regulation (reducing) of Positive_regulation (circulating) of prolactin
12) Confidence 0.03 Published 2010 Journal Reprod Biol Endocrinol Section Body Doc Link PMC2958977 Disease Relevance 0.58 Pain Relevance 0

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