INT4487

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Context Info
Confidence 0.70
First Reported 1975
Last Reported 2008
Negated 3
Speculated 2
Reported most in Body
Documents 27
Total Number 29
Disease Relevance 8.06
Pain Relevance 8.09

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cell proliferation (PRL) cytosol (PRL) extracellular region (PRL)
Anatomy Link Frequency
plasma 6
thyroid 4
blood 2
PRL (Homo sapiens)
Pain Link Frequency Relevance Heat
narcan 40 100.00 Very High Very High Very High
Dynorphin 11 99.86 Very High Very High Very High
depression 78 99.80 Very High Very High Very High
Enkephalin 5 99.72 Very High Very High Very High
fluoxetine 70 99.60 Very High Very High Very High
Morphine 45 99.54 Very High Very High Very High
opioid receptor 5 99.52 Very High Very High Very High
noradrenaline 2 99.44 Very High Very High Very High
Analgesic 3 99.12 Very High Very High Very High
opiate 32 98.84 Very High Very High Very High
Disease Link Frequency Relevance Heat
Vomiting 31 99.86 Very High Very High Very High
Depression 117 99.80 Very High Very High Very High
Thyroid Neoplasm 2 99.56 Very High Very High Very High
Obesity 11 99.40 Very High Very High Very High
Galactorrhea 922 99.18 Very High Very High Very High
Metastasis 2 99.16 Very High Very High Very High
Reprotox - General 1 209 97.84 Very High Very High Very High
Disease 31 96.24 Very High Very High Very High
Cancer 18 95.60 Very High Very High Very High
Headache 9 94.44 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
As a possible trigger, an intracranial metastasis of a thyroid cancer was found which also caused elevated serum prolactin.
Positive_regulation (caused) of Positive_regulation (elevated) of prolactin in thyroid associated with thyroid neoplasm and metastasis
1) Confidence 0.70 Published 2008 Journal Nervenarzt Section Abstract Doc Link 18210040 Disease Relevance 1.05 Pain Relevance 0.44
The patients presented agalactia and suckling did not induce a PRL increase.
Neg (not) Positive_regulation (induce) of Neg (not) Positive_regulation (increase) of PRL
2) Confidence 0.70 Published 1981 Journal Int. J. Fertil. Section Abstract Doc Link 6114069 Disease Relevance 0.75 Pain Relevance 0.07
As a result, all of the DST nonsuppressors showed no increased response of prolactin after L-5HTP loading.
Neg (no) Positive_regulation (increased) of Neg (no) Positive_regulation (response) of prolactin
3) Confidence 0.65 Published 1990-1991 Journal Neuropsychobiology Section Abstract Doc Link 2132636 Disease Relevance 0.15 Pain Relevance 0.50
Nalmefene induced elevation in serum prolactin in normal human volunteers: partial kappa opioid agonist activity?
Positive_regulation (induced) of Positive_regulation (elevation) of serum prolactin associated with mu agonist
4) Confidence 0.59 Published 2005 Journal Neuropsychopharmacology Section Title Doc Link 15988468 Disease Relevance 0.08 Pain Relevance 0.48
Prolactin stimulation by protein is mediated by amino acids in humans.
Positive_regulation (mediated) of Positive_regulation (stimulation) of Prolactin associated with narcan
5) Confidence 0.50 Published 1989 Journal J. Clin. Endocrinol. Metab. Section Title Doc Link 2732299 Disease Relevance 0 Pain Relevance 0.18
More specifically, only clozapine and risperidone result in a pathologic elevation, while olanzapine-induced prolactin increase is always within normal range (Turrone et al 2002).
Positive_regulation (induced) of Positive_regulation (increase) of prolactin
6) Confidence 0.50 Published 2007 Journal Therapeutics and Clinical Risk Management Section Body Doc Link PMC2376090 Disease Relevance 0.13 Pain Relevance 0.11
However, since the prolactin secretory pattern of drug-free psychiatric patients, measured throughout the day, is not different from that observed in healthy control subjects, the elevation of baseline prolactin in treated psychiatric patients seems to be more related to drug effects rather than to the illness itself (Haddad and Wieck 2004).
Spec (seems) Positive_regulation (since) of Positive_regulation (elevation) of prolactin
7) Confidence 0.50 Published 2007 Journal Therapeutics and Clinical Risk Management Section Body Doc Link PMC2376090 Disease Relevance 0.71 Pain Relevance 0.25
The abolishment of prolactin response to clomipramine after pre-treatment with serotonin receptor blockers clozapine and olanzapine (Markianos et al 2002) and its enhancement after L-tryptophan (Anderson and Cowen 1986) confirm the involvement of serotoninergic pathway in clomipramine-induced prolactin increase.
Positive_regulation (induced) of Positive_regulation (increase) of prolactin associated with serotonin
8) Confidence 0.50 Published 2007 Journal Therapeutics and Clinical Risk Management Section Body Doc Link PMC2376090 Disease Relevance 0.15 Pain Relevance 0.25
An elevated PRL level was common finding during and after operation with the peak PRL levels always occurring during surgery.
Positive_regulation (finding) of Positive_regulation (elevated) of PRL
9) Confidence 0.50 Published 2005 Journal Reprod Biol Endocrinol Section Body Doc Link PMC1188073 Disease Relevance 0.63 Pain Relevance 0.24
Prolactin elevation induced by a single fluphenazine injection was found to last up to 28 days.
Positive_regulation (induced) of Positive_regulation (elevation) of Prolactin
10) Confidence 0.47 Published 2007 Journal Therapeutics and Clinical Risk Management Section Body Doc Link PMC2376090 Disease Relevance 0.40 Pain Relevance 0
Among those, sertraline appears to be the most frequent cause of sustained hyperprolactinemia, but also fluoxetine and paroxetine may induce pathologic and symptomatic increases in prolactin levels.
Spec (may) Positive_regulation (induce) of Positive_regulation (increases) of prolactin associated with galactorrhea and fluoxetine
11) Confidence 0.47 Published 2007 Journal Therapeutics and Clinical Risk Management Section Body Doc Link PMC2376090 Disease Relevance 0.64 Pain Relevance 0.49
In the same study (Hinterberger-Fischer MM et al 2000), the use of antiemetic drugs induced further increase in prolactin levels.
Positive_regulation (induced) of Positive_regulation (increase) of prolactin associated with vomiting
12) Confidence 0.47 Published 2007 Journal Therapeutics and Clinical Risk Management Section Body Doc Link PMC2376090 Disease Relevance 0.34 Pain Relevance 0
Risperidone causes more marked elevations in prolactin than other atypical antipsychotics because it does not fully cross the blood-brain barrier, hence D2 receptor occupancy is higher at the level of the pituitary than in the striatum.
Positive_regulation (causes) of Positive_regulation (elevations) of prolactin in blood
13) Confidence 0.47 Published 2007 Journal Therapeutics and Clinical Risk Management Section Body Doc Link PMC2376090 Disease Relevance 0.71 Pain Relevance 0.48
Domperidone causes an increase in maternal prolactin levels and has been shown to significantly increase human breast milk volumes.
Positive_regulation (causes) of Positive_regulation (increase) of prolactin
14) Confidence 0.46 Published 2006 Journal BMC Pregnancy Childbirth Section Body Doc Link PMC1562444 Disease Relevance 0 Pain Relevance 0
Phentolamine failed to alter the PRL rise induced by FK 33-824, while combined FK 33-824-metoclopramide administration induced a greater PRL increase than FK 33-824 alone.
Positive_regulation (induced) of Positive_regulation (increase) of PRL
15) Confidence 0.46 Published 1983 Journal Psychopharmacology (Berl.) Section Abstract Doc Link 6308703 Disease Relevance 0 Pain Relevance 0.26
The intravenous administration of 250 micrograms D-Ala2-MePhe4-Met-enkephalin-O-ol (DAMME) caused a marked increase in circulating growth hormone (GH) and prolactin (PRL), and a fall in cortisol, in 14 normal subjects.
Positive_regulation (caused) of Positive_regulation (increase) of PRL associated with enkephalin
16) Confidence 0.46 Published 1986 Journal Horm. Res. Section Abstract Doc Link 2935474 Disease Relevance 0 Pain Relevance 0.41
Morphine administration in man results in a significant increase in serum prolactin without altering the levels of growth hormone, thyroid stimulating hormone and cortisol.
Positive_regulation (results) of Positive_regulation (increase) of prolactin in thyroid associated with morphine
17) Confidence 0.46 Published 1975 Journal J. Clin. Endocrinol. Metab. Section Abstract Doc Link 1176587 Disease Relevance 0.08 Pain Relevance 0.27
Analgesic nitrous oxide (mean concentration = 48.8%) produced statistically significant elevation of prolactin and depression of cortisol whilst not producing statistically significant changes in the other hormones assayed.
Neg (not) Positive_regulation (produced) of Positive_regulation (elevation) of prolactin associated with depression and analgesic
18) Confidence 0.46 Published 1988 Journal Horm. Metab. Res. Section Abstract Doc Link 2851516 Disease Relevance 0.10 Pain Relevance 0.39
Dynorphin A1-13 causes elevation of serum levels of prolactin through an opioid receptor mechanism in humans: gender differences and implications for modulation of dopaminergic tone in the treatment of addictions.
Positive_regulation (causes) of Positive_regulation (elevation) of prolactin associated with dynorphin and opioid receptor
19) Confidence 0.45 Published 1999 Journal J. Pharmacol. Exp. Ther. Section Title Doc Link 9862779 Disease Relevance 0.07 Pain Relevance 0.70
The mean PRL level increased significantly during hypocortisolism, compared with normocortisolism (5.8 +/- 0.4 vs. 3.6 +/- 0.2 microg/L; P < 0.001), and naloxone induced an increase in PRL levels both during hypo- and normocortisolism (7.1 +/- 0.7 vs. 4.7 +/- 0.5 microg/L, respectively; P < 0.01).
Positive_regulation (induced) of Positive_regulation (increase) of PRL associated with narcan
20) Confidence 0.45 Published 1999 Journal J. Clin. Endocrinol. Metab. Section Abstract Doc Link 10323386 Disease Relevance 0.07 Pain Relevance 0.46

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