INT44873

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Context Info
Confidence 0.59
First Reported 1980
Last Reported 2010
Negated 0
Speculated 0
Reported most in Abstract
Documents 16
Total Number 16
Disease Relevance 6.92
Pain Relevance 3.13

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (LCAT) small molecule metabolic process (LCAT) extracellular region (LCAT)
transferase activity, transferring acyl groups (LCAT) lipid metabolic process (LCAT)
Anatomy Link Frequency
plasma 4
skin 2
histiocytes 1
spleen 1
kidney 1
LCAT (Homo sapiens)
Pain Link Frequency Relevance Heat
local anesthetic 24 99.84 Very High Very High Very High
lidocaine 9 99.32 Very High Very High Very High
beta blocker 6 95.20 Very High Very High Very High
Pain 13 67.04 Quite High
abdominal pain 3 38.72 Quite Low
Inflammation 6 31.20 Quite Low
anesthesia 2 12.68 Low Low
fibrosis 4 5.00 Very Low Very Low Very Low
Angina 2 5.00 Very Low Very Low Very Low
peripheral neuropathy 2 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Fabry Disease 4 100.00 Very High Very High Very High
Cystinosis 2 100.00 Very High Very High Very High
Dyslipidemia /

Combined Dyslipidemia

7 99.62 Very High Very High Very High
Lysosomal Storage Diseases 2 99.56 Very High Very High Very High
Renal Disease 6 99.26 Very High Very High Very High
Disorder Of Lipid Metabolism 292 98.80 Very High Very High Very High
Splenomegaly 9 98.48 Very High Very High Very High
Mucopolysaccharidoses 14 98.44 Very High Very High Very High
Lipidosis 2 97.52 Very High Very High Very High
Sialidosis 4 97.08 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Histologic and ultrastructural findings in the kidney and spleen raised the likelihood of lecithin-cholesterol acyltransferase (LCAT) deficiency, which was confirmed by the markedly decreased serum LCAT activity and serum LCAT mass.
Negative_regulation (decreased) of LCAT in kidney
1) Confidence 0.59 Published 2009 Journal Metab. Clin. Exp. Section Abstract Doc Link 19592052 Disease Relevance 0.85 Pain Relevance 0.07
Because LCAT inhibition is followed by a decrease of HDL cholesterol and an increase of triglycerides in plasma, it is recommended to use only beta-blockers without such side effects on lipoprotein metabolism for therapeutical purposes.
Negative_regulation (inhibition) of LCAT in plasma associated with beta blocker and disorder of lipid metabolism
2) Confidence 0.59 Published 1984 Journal Int J Clin Pharmacol Ther Toxicol Section Abstract Doc Link 6548729 Disease Relevance 0.10 Pain Relevance 0.48
Therefore, the inhibition of LCAT activity by beta-blocking drugs may be connected with their local anesthetic properties.
Negative_regulation (inhibition) of LCAT associated with local anesthetic
3) Confidence 0.59 Published 1984 Journal Int J Clin Pharmacol Ther Toxicol Section Abstract Doc Link 6548729 Disease Relevance 0.09 Pain Relevance 0.49
Both D-propranolol and L-propranolol inhibited LCAT activity, the former being a little more effective.
Negative_regulation (inhibited) of LCAT
4) Confidence 0.59 Published 1984 Journal Int J Clin Pharmacol Ther Toxicol Section Abstract Doc Link 6548729 Disease Relevance 0.07 Pain Relevance 0.50
Since LCAT activity represents the combined effect of a deacylation step and an esterification step, inhibition of LCAT by local anesthetics could theoretically involve either or both steps.
Negative_regulation (inhibition) of LCAT associated with local anesthetic
5) Confidence 0.59 Published 1980 Journal Lipids Section Abstract Doc Link 7442470 Disease Relevance 0 Pain Relevance 0.36
The percentage of plasma [14C]cholesterol esterified in the lidocaine-treated group was similar to control values and did not reflect its ability to inhibit LCAT in vitro.
Negative_regulation (inhibit) of LCAT in plasma associated with lidocaine
6) Confidence 0.52 Published 1981 Journal Lipids Section Abstract Doc Link 7311740 Disease Relevance 0 Pain Relevance 0.17
Chlorpromazine (CPZ), a major tranquilizer, was found to be a potent inhibitor of lecithin:cholesterol acyltransferase (LCAT, EC 2.3.1.43) in the plasma of normal man, rat, rabbit and dog in vitro.
Negative_regulation (inhibitor) of LCAT in plasma
7) Confidence 0.52 Published 1981 Journal Lipids Section Abstract Doc Link 7311740 Disease Relevance 0 Pain Relevance 0.08
In all species examined, various local anesthetics were found to inhibit LCAT when studied over the concentration range of 1 to 5 mM.
Negative_regulation (inhibit) of LCAT associated with local anesthetic
8) Confidence 0.51 Published 1980 Journal Lipids Section Abstract Doc Link 7442470 Disease Relevance 0 Pain Relevance 0.34
Inhibition of LCAT in plasma from man and experimental animals by chlorpromazine.
Negative_regulation (Inhibition) of LCAT in plasma
9) Confidence 0.45 Published 1981 Journal Lipids Section Title Doc Link 7311740 Disease Relevance 0 Pain Relevance 0.14
We describe a case with the triad of splenomegaly with sea-blue histiocytes, nephropathy, and dyslipidemia in a patient with LCAT deficiency.
Negative_regulation (deficiency) of LCAT in histiocytes associated with splenomegaly and renal disease
10) Confidence 0.43 Published 2009 Journal Metab. Clin. Exp. Section Abstract Doc Link 19592052 Disease Relevance 0.85 Pain Relevance 0.06
Since LCAT activity represents the combined effect of a deacylation step and an esterification step, inhibition of LCAT by local anesthetics could theoretically involve either or both steps.
Negative_regulation (represents) of LCAT associated with local anesthetic
11) Confidence 0.43 Published 1980 Journal Lipids Section Abstract Doc Link 7442470 Disease Relevance 0 Pain Relevance 0.36
Main differential diagnoses include various causes of monoclonal gammopathy, lecithin-cholesterol-acyltransferase deficiency, Fabry disease, cystinosis, tyrosine transaminase deficiency, systemic lysosomal storage diseases (mucopolysaccharidoses, lipidoses, mucolipidoses), and several skin diseases (X-linked ichthyosis, keratosis follicularis spinolosa decalvans).
Negative_regulation (deficiency) of lecithin-cholesterol-acyltransferase in skin associated with darier's disease, skin diseases, mucopolysaccharidoses, fabry disease, sialidosis, cystinosis, ichthyosis, lysosomal storage diseases and lipidosis
12) Confidence 0.22 Published 2009 Journal Orphanet J Rare Dis Section Abstract Doc Link PMC2695576 Disease Relevance 1.16 Pain Relevance 0
Main differential diagnoses include various causes of monoclonal gammopathy, lecithin-cholesterol-acyltransferase deficiency, Fabry disease, cystinosis, tyrosine transaminase deficiency, systemic lysosomal storage diseases (mucopolysaccharidoses, lipidoses, mucolipidoses), and several skin diseases (X-linked ichthyosis, keratosis follicularis spinolosa decalvans).
Negative_regulation (deficiency) of lecithin-cholesterol-acyltransferase in skin associated with darier's disease, skin diseases, mucopolysaccharidoses, fabry disease, sialidosis, cystinosis, ichthyosis, lysosomal storage diseases and lipidosis
13) Confidence 0.22 Published 2009 Journal Orphanet J Rare Dis Section Abstract Doc Link PMC2695576 Disease Relevance 1.08 Pain Relevance 0
Histologic and ultrastructural findings in the kidney and spleen raised the likelihood of lecithin-cholesterol acyltransferase (LCAT) deficiency, which was confirmed by the markedly decreased serum LCAT activity and serum LCAT mass.
Negative_regulation (decreased) of LCAT in spleen
14) Confidence 0.20 Published 2009 Journal Metab. Clin. Exp. Section Abstract Doc Link 19592052 Disease Relevance 0.85 Pain Relevance 0.07
It has been reported that high levels of TG are associated with impaired LPL and LCAT activities [29,30].
Negative_regulation (impaired) of LCAT
15) Confidence 0.18 Published 2010 Journal Lipids Health Dis Section Body Doc Link PMC2920871 Disease Relevance 1.23 Pain Relevance 0
Physiological CETP activity was determined without inhibiting LCAT activity by measuring the mass transfer of cholesterol ester between HDL and apo B containing lipoproteins.
Negative_regulation (inhibiting) of LCAT associated with disorder of lipid metabolism
16) Confidence 0.08 Published 2005 Journal BMC Cardiovasc Disord Section Body Doc Link PMC1262701 Disease Relevance 0.32 Pain Relevance 0

General Comments

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