INT44878

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Context Info
Confidence 0.75
First Reported 1984
Last Reported 2010
Negated 0
Speculated 0
Reported most in Abstract
Documents 7
Total Number 7
Disease Relevance 0.78
Pain Relevance 0.42

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

Anatomy Link Frequency
spine 1
TSC22D3 (Homo sapiens)
Pain Link Frequency Relevance Heat
Thalamus 5 97.08 Very High Very High Very High
Eae 7 91.12 High High
rheumatoid arthritis 1 83.80 Quite High
spinal inflammation 1 63.44 Quite High
Morphine 23 37.84 Quite Low
antagonist 9 33.92 Quite Low
alcohol 5 25.00 Low Low
Nucleus accumbens 2 17.24 Low Low
cocaine 19 5.00 Very Low Very Low Very Low
addiction 14 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Rheumatoid Arthritis 1 83.80 Quite High
Cardiovascular Disease 1 82.88 Quite High
Systemic Lupus Erythematosus 1 68.28 Quite High
Nasal Polyps 2 65.76 Quite High
Disease 11 64.28 Quite High
Low Back Pain 1 63.44 Quite High
Leukemia 2 61.56 Quite High
Targeted Disruption 1 60.40 Quite High
Inflammatory Bowel Disease 2 60.36 Quite High
Asthma 3 55.80 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Transfection with the GILZ shRNA (GILZsh) mix, however, caused pronounced changes in spine morphology.
Gene_expression (Transfection) of GILZ in spine
1) Confidence 0.75 Published 2010 Journal Genome Biol Section Body Doc Link PMC2898085 Disease Relevance 0.06 Pain Relevance 0
Both forms, DSIP and DSIP-P occur in human CSF.
Gene_expression (occur) of DSIP-P
2) Confidence 0.63 Published 1984 Journal Eur. Neurol. Section Abstract Doc Link 6548966 Disease Relevance 0 Pain Relevance 0.07
Both forms, DSIP and DSIP-P occur in human CSF.
Gene_expression (occur) of DSIP
3) Confidence 0.63 Published 1984 Journal Eur. Neurol. Section Abstract Doc Link 6548966 Disease Relevance 0 Pain Relevance 0.07
Subsequently, intravenous administration of DSIP was shown to produce, in different animals, sleep lasting for hours.
Gene_expression (produce) of DSIP
4) Confidence 0.63 Published 1984 Journal Eur. Neurol. Section Abstract Doc Link 6548966 Disease Relevance 0 Pain Relevance 0.07
From 1970 to 1977 we isolated, characterized and synthesized a nonapeptide called delta-sleep-inducing peptide (DSIP) responsible for this effect.
Gene_expression (synthesized) of DSIP
5) Confidence 0.49 Published 1984 Journal Eur. Neurol. Section Abstract Doc Link 6548966 Disease Relevance 0 Pain Relevance 0.05
From 1970 to 1977 we isolated, characterized and synthesized a nonapeptide called delta-sleep-inducing peptide (DSIP) responsible for this effect.
Gene_expression (synthesized) of delta-sleep-inducing peptide
6) Confidence 0.49 Published 1984 Journal Eur. Neurol. Section Abstract Doc Link 6548966 Disease Relevance 0 Pain Relevance 0.05
In PBMLs derived from carriers, the glucocorticoid-induced transrepression of IL-2 mRNA expression was reduced, but the induction of GILZ mRNA expression by glucocorticoids was not different from non-carriers [van den Akker et al., 2006b].
Gene_expression (expression) of GILZ mRNA
7) Confidence 0.01 Published 2009 Journal Nuclear Receptor Signaling Section Body Doc Link PMC2716050 Disease Relevance 0.72 Pain Relevance 0.11

General Comments

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