INT44880

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Context Info
Confidence 0.30
First Reported 1984
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 21
Total Number 21
Disease Relevance 5.30
Pain Relevance 2.43

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

signal transduction (REM1) GTPase activity (REM1)
Anatomy Link Frequency
eye 2
neurons 1
epithelial cell 1
cortex 1
neural 1
REM1 (Homo sapiens)
Pain Link Frequency Relevance Heat
Hippocampus 441 100.00 Very High Very High Very High
primary somatosensory cortex 350 100.00 Very High Very High Very High
sSRI 21 90.56 High High
tricyclic antidepressant 7 88.20 High High
addiction 8 87.40 High High
depression 107 85.20 High High
cerebral cortex 28 84.16 Quite High
Eae 1 82.48 Quite High
Thalamus 2 76.88 Quite High
monoamine 20 66.44 Quite High
Disease Link Frequency Relevance Heat
Apnoea 137 99.00 Very High Very High Very High
Sleep Disorders 157 98.92 Very High Very High Very High
Aids-related Complex 245 98.72 Very High Very High Very High
Stomach Cancer 54 98.40 Very High Very High Very High
Disease 97 94.44 High High
Lifespan 13 92.56 High High
Sleep Apnea Syndromes 8 90.72 High High
Depression 141 85.20 High High
Metastasis 18 81.20 Quite High
Cancer 31 80.76 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
In contrast agomelatine did not change rapid eye movement (REM) latency, amount of REM, or REM density.49
Gene_expression (amount) of REM in eye
1) Confidence 0.30 Published 2010 Journal Core evidence Section Body Doc Link PMC2899775 Disease Relevance 0.35 Pain Relevance 0.15
In contrast agomelatine did not change rapid eye movement (REM) latency, amount of REM, or REM density.49
Gene_expression (amount) of REM in eye
2) Confidence 0.30 Published 2010 Journal Core evidence Section Body Doc Link PMC2899775 Disease Relevance 0.35 Pain Relevance 0.15
The data was then collated to see if there were differences between the UGES and GES groups and if there were any gender related differences between the men and women in the combined groups.
Gene_expression (groups) of GES
3) Confidence 0.25 Published 2010 Journal Evidence-based Complementary and Alternative Medicine : eCAM Section Body Doc Link PMC2862934 Disease Relevance 0 Pain Relevance 0.03
The duration of time spent in any stage, measured in units of 30-second epochs, was analyzed for each group, including wake (after sleep onset; WASO), NREM1, NREM2, NREM3, NREM4, and REM sleep stages.
Gene_expression (stages) of REM
4) Confidence 0.24 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2893208 Disease Relevance 0.33 Pain Relevance 0
The optimal exponential fits are shown for NREM and REM bouts across all three cohorts in Figure 4.
Gene_expression (bouts) of REM
5) Confidence 0.24 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2893208 Disease Relevance 0.26 Pain Relevance 0
The optimal number of NREM exponentials was 3 for three of the four groups, and 2 exponentials were optimal for the REM distributions across all four groups (similar to the full dataset).
Gene_expression (distributions) of REM
6) Confidence 0.24 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2893208 Disease Relevance 0 Pain Relevance 0
For example, the faster overall decay of the REM bout distributions with OSA was attributed to faster time constants (particularly of the fast exponential) as well as an increase of the relative contribution of the fast component (at the expense of the slow component).
Gene_expression (decay) of REM associated with apnoea
7) Confidence 0.24 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2893208 Disease Relevance 0.33 Pain Relevance 0
It is due to failure of the mechanism that produces atonia during REM sleep.
Gene_expression (produces) of REM
8) Confidence 0.21 Published 2010 Journal International Journal of Alzheimer's Disease Section Body Doc Link PMC2939436 Disease Relevance 0.78 Pain Relevance 0.09
Responders in this study showed improved mood scores during the LP after early-SD, which were significantly correlated with changes in REM sleep and ROL, indicating REM parameters to be important for the therapeutic effects of SD.
Gene_expression (sleep) of REM associated with sleep disorders
9) Confidence 0.09 Published 2010 Journal International Journal of Endocrinology Section Body Doc Link PMC2817387 Disease Relevance 0.87 Pain Relevance 0
Sleep propensity (defined in the study as the sum of the duration of stages 2, 3, 4 and REM sleep occurring at each 10-minute nap trial) varied significantly across the circadian day, but did not differ between menstrual phases.
Gene_expression (sleep) of REM
10) Confidence 0.09 Published 2010 Journal International Journal of Endocrinology Section Body Doc Link PMC2817387 Disease Relevance 0.06 Pain Relevance 0
We found that the normal immortal human gastric mucosal epithelial cell line GES-1 expressed high level of p16(INK4a); while 3 of 8 gastric cancer cell lines expressed lower level of p16(INK4a), and 5 of 8 gastric cancer cell lines did not express detectable p16(INK4a).
Gene_expression (expressed) of GES-1 in epithelial cell associated with stomach cancer
11) Confidence 0.07 Published 2010 Journal J Exp Clin Cancer Res Section Body Doc Link PMC2933612 Disease Relevance 1.09 Pain Relevance 0
The mechanisms relating neural activity and IEG expression during sleep remain uncharted, and the model does not take into account the short intermediate sleep (IS) between SWS and REM sleep, a distinct state (Gottesmann, 1996) characterized by robust spindle oscillations that could in principle trigger IEG expression instead of REM sleep (Gervasoni et al., 2004).
Gene_expression (expression) of REM in neural
12) Confidence 0.05 Published 2007 Journal Frontiers in Neuroscience Section Body Doc Link PMC2577304 Disease Relevance 0 Pain Relevance 0.09
Despite the link between cortical IEG upregulation and post-experience REM sleep, analysis of the relation between IEG expression in S1 and time spent in REM sleep within 60?
Gene_expression (sleep) of REM associated with primary somatosensory cortex
13) Confidence 0.05 Published 2007 Journal Frontiers in Neuroscience Section Body Doc Link PMC2577304 Disease Relevance 0.23 Pain Relevance 0.61
Four hours after experience, IEG expression was specifically upregulated during REM sleep in the cortex, but not in the hippocampus.
Gene_expression (sleep) of REM in cortex associated with hippocampus
14) Confidence 0.05 Published 2007 Journal Frontiers in Neuroscience Section Abstract Doc Link PMC2577304 Disease Relevance 0.17 Pain Relevance 0.26
Despite the link between cortical IEG upregulation and post-experience REM sleep, analysis of the relation between IEG expression in S1 and time spent in REM sleep within 60?
Gene_expression (sleep) of REM associated with primary somatosensory cortex
15) Confidence 0.05 Published 2007 Journal Frontiers in Neuroscience Section Body Doc Link PMC2577304 Disease Relevance 0.23 Pain Relevance 0.59
Indeed, IEG reinduction during REM sleep may explain the second wave of arc protein expression detected 8–24?
Gene_expression (sleep) of REM associated with aids-related complex
16) Confidence 0.05 Published 2007 Journal Frontiers in Neuroscience Section Body Doc Link PMC2577304 Disease Relevance 0.20 Pain Relevance 0
Next, we compared the mean firing rates of activated neurons in S1, HP, and V1 across WK, SWS, and REM sleep occurring between 2?
Gene_expression (neurons) of REM in neurons associated with primary somatosensory cortex and hippocampus
17) Confidence 0.05 Published 2007 Journal Frontiers in Neuroscience Section Body Doc Link PMC2577304 Disease Relevance 0 Pain Relevance 0.18
The lack of correlation between time spent in REM sleep and IEG expression indicates that REM sleep plays a brief and mostly permissive role on IEG upregulation, in line with the fact that birds and crocodilians display hundreds of seconds long REM sleep episodes overnight (Siegel, 1995).
Gene_expression (expression) of REM
18) Confidence 0.04 Published 2007 Journal Frontiers in Neuroscience Section Body Doc Link PMC2577304 Disease Relevance 0.05 Pain Relevance 0
Similar effects were seen for mean REM sleep bout durations in the post-MD period (Fig. 1C), which were significantly reduced in all three hypnotic-treated groups relative to VEH (effects of treatment on REM sleep and wake bout durations: F?
Gene_expression (durations) of REM
19) Confidence 0.04 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2699540 Disease Relevance 0 Pain Relevance 0.14
Similar effects were seen for mean REM sleep bout durations in the post-MD period (Fig. 1C), which were significantly reduced in all three hypnotic-treated groups relative to VEH (effects of treatment on REM sleep and wake bout durations: F?
Gene_expression (sleep) of REM
20) Confidence 0.04 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2699540 Disease Relevance 0 Pain Relevance 0.06

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