INT4489

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Context Info
Confidence 0.66
First Reported 1975
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 5
Total Number 9
Disease Relevance 5.39
Pain Relevance 1.91

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

Anatomy Link Frequency
lungs 2
epithelium 1
stomach 1
neutrophil 1
Muc5ac (Mus musculus)
Pain Link Frequency Relevance Heat
antagonist 4 100.00 Very High Very High Very High
Inflammation 91 99.24 Very High Very High Very High
Morphine 5 98.96 Very High Very High Very High
Antinociceptive 8 95.08 Very High Very High Very High
Analgesic 2 92.64 High High
tolerance 1 88.92 High High
Kappa opioid receptor 3 85.16 High High
addiction 5 83.68 Quite High
Bile 1 81.36 Quite High
cytokine 12 77.52 Quite High
Disease Link Frequency Relevance Heat
Stomach Cancer 1 99.86 Very High Very High Very High
INFLAMMATION 101 99.24 Very High Very High Very High
Metaplasia 1 98.08 Very High Very High Very High
Asthma 53 97.84 Very High Very High Very High
Pulmonary Disease 114 97.28 Very High Very High Very High
Duodenal Ulcer 2 96.48 Very High Very High Very High
Bacterial Meningitis 5 95.88 Very High Very High Very High
Injury 45 95.08 Very High Very High Very High
Smoke Inhalation Injury 75 92.32 High High
Occupational Lung Diseases 2 87.44 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Intratracheal instillation of IL-13 elicited huge amount of induction of MUC5AC mRNA within 24 hour in wild-type mouse lung [20].
Positive_regulation (induction) of MUC5AC mRNA in lung
1) Confidence 0.66 Published 2010 Journal Respir Res Section Body Doc Link PMC3014901 Disease Relevance 0.47 Pain Relevance 0.08
Similar to the present study, MUC5AC can be induced within 24 hour of inflammatory or bacterial stimulation.
Positive_regulation (induced) of MUC5AC associated with inflammation
2) Confidence 0.57 Published 2010 Journal Respir Res Section Body Doc Link PMC3014901 Disease Relevance 0.52 Pain Relevance 0.09
The rewarding effect of MGM-9 was blocked by a mu antagonist and enhanced by a kappa antagonist.
Positive_regulation (enhanced) of MGM-9 associated with antagonist
3) Confidence 0.50 Published 2008 Journal Neuropharmacology Section Abstract Doc Link 18550129 Disease Relevance 0 Pain Relevance 1.32
Northern blot analysis using 3 mice showed an increase of the Muc5ac messenger with a peak at day 4 followed by a decrease of Muc5ac RNA [41].
Positive_regulation (increase) of Muc5ac
4) Confidence 0.47 Published 2007 Journal Respir Res Section Body Doc Link PMC1899493 Disease Relevance 0.28 Pain Relevance 0
Four and twenty-four hours after exposure to smoke from burning cotton, we observed that MUC5AC mRNA levels were elevated in the mouse lungs, and MUC5AC protein was expressed predominantly in the surface cells of the mouse airway.
Positive_regulation (elevated) of MUC5AC mRNA in lungs
5) Confidence 0.44 Published 2010 Journal Respir Res Section Body Doc Link PMC3014901 Disease Relevance 0.54 Pain Relevance 0.07
Twelve hour of human neutrophil peptide-1 or lipopolysaccharide incubation caused an increase in MUC5AC mRNA levels [22].
Positive_regulation (increase) of MUC5AC mRNA in neutrophil
6) Confidence 0.44 Published 2010 Journal Respir Res Section Body Doc Link PMC3014901 Disease Relevance 0.48 Pain Relevance 0.07
Smoke exposure caused an increase in the production of mucus in the airway epithelium of the mice along with an increase in MUC5AC gene and protein expression, while the expression of MUC5B was not increased compared with control.
Positive_regulation (increase) of MUC5AC in epithelium
7) Confidence 0.44 Published 2010 Journal Respir Res Section Abstract Doc Link PMC3014901 Disease Relevance 0.63 Pain Relevance 0
At least in vitro, epidermal growth factor stimulates MUC5AC mRNA and protein expression; this can be reversed by PDE 4 inhibitors, which may contribute to their clinical efficacy in COPD and asthma (Mata et al 2005).
Positive_regulation (stimulates) of MUC5AC mRNA associated with asthma and pulmonary disease
8) Confidence 0.16 Published 2007 Journal International Journal of Chronic Obstructive Pulmonary Disease Section Body Doc Link PMC2699952 Disease Relevance 2.03 Pain Relevance 0.17
Twenty-seven patients who developed cancer of the stomach after undergoing gastric resection (GR), gastroenterostomy (GE), and vagotomy and pyloroplasty (VP) for benign gastric or duodenal ulcer are reported.
Positive_regulation (undergoing) of gastric resection in stomach associated with duodenal ulcer and stomach cancer
9) Confidence 0.03 Published 1975 Journal J Surg Oncol Section Abstract Doc Link 1177463 Disease Relevance 0.43 Pain Relevance 0.10

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