INT44899

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Context Info
Confidence 0.45
First Reported 1983
Last Reported 2010
Negated 0
Speculated 0
Reported most in Abstract
Documents 3
Total Number 3
Disease Relevance 1.67
Pain Relevance 0.51

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (EIF2S1) RNA binding (EIF2S1) nucleus (EIF2S1)
translation (EIF2S1) cytoplasm (EIF2S1)
Anatomy Link Frequency
reticulum 1
EIF2S1 (Homo sapiens)
Pain Link Frequency Relevance Heat
cINOD 6 95.12 Very High Very High Very High
Inflammation 2 86.00 High High
Pain 1 53.68 Quite High
lidocaine 1 5.00 Very Low Very Low Very Low
anesthesia 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Cancer 3 97.16 Very High Very High Very High
Hypoxia 31 92.80 High High
Stress 9 91.16 High High
Apoptosis 4 89.84 High High
INFLAMMATION 2 86.00 High High
Colon Cancer 2 75.52 Quite High
Ehrlich Tumor Carcinoma 1 75.00 Quite High
Intestinal Cancer 1 75.00 Quite High
Pain 1 53.68 Quite High
Frailty 1 28.12 Quite Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Sulindac sulfide, the active sulindac metabolite, was shown to trigger the ISRs via eIF2alpha kinase such as RNA-dependent protein kinase-related endoplasmic reticulum kinase (PERK) and RNA-dependent protein kinase (PKR).
Positive_regulation (trigger) of eIF2alpha in reticulum
1) Confidence 0.45 Published 2010 Journal Carcinogenesis Section Abstract Doc Link 20130018 Disease Relevance 1.23 Pain Relevance 0.46
The protein expression and phosphorylation state of the eukaryotic translation initiation factor 2 alpha (eIF2?)
Positive_regulation (state) of eukaryotic translation initiation factor 2 alpha
2) Confidence 0.33 Published 2010 Journal PLoS ONE Section Body Doc Link PMC3004931 Disease Relevance 0.31 Pain Relevance 0
If eIF-2 X GDP is actually the complex released, then GEF is absolutely required for eIF-2 to cycle and it is therefore a new eukaryotic initiation factor.
Positive_regulation (required) of eIF-2
3) Confidence 0.18 Published 1983 Journal J. Biol. Chem. Section Abstract Doc Link 6553052 Disease Relevance 0.13 Pain Relevance 0.05

General Comments

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