INT449

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Context Info
Confidence 0.66
First Reported 1979
Last Reported 2008
Negated 0
Speculated 0
Reported most in Body
Documents 4
Total Number 5
Disease Relevance 2.29
Pain Relevance 0.33

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cell proliferation (PDAP1) signal transduction (PDAP1)
Anatomy Link Frequency
cardiogenic 2
external 1
PDAP1 (Homo sapiens)
Pain Link Frequency Relevance Heat
medulla 1 92.64 High High
Enkephalin 3 91.32 High High
substance P 2 90.44 High High
Catecholamine 5 76.96 Quite High
Angina 1 13.48 Low Low
tolerance 5 6.92 Low Low
Neuropeptide 25 5.00 Very Low Very Low Very Low
cva 22 5.00 Very Low Very Low Very Low
Dopamine 9 5.00 Very Low Very Low Very Low
antagonist 8 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Pulmonary Alveolar Proteinosis 49 100.00 Very High Very High Very High
Pulmonary Hypertension 378 98.88 Very High Very High Very High
Hypotension 50 95.04 Very High Very High Very High
Shock 23 90.00 High High
Death 22 89.60 High High
Cv General 2 Under Development 6 80.72 Quite High
Respiratory Failure 8 77.32 Quite High
Pulmonary Heart Disease 44 76.04 Quite High
Left Ventricular Dysfunction 4 62.80 Quite High
Cv General 4 Under Development 30 56.64 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
In some circumstances serious and prolonged elevation of PAP progresses to severe acute pulmonary hypertension, leading to life threatening complications including refractory systemic arterial hypotension, severe hypoxemia, RV dysfunction and failure and ultimately resulting in cardiogenic and/or obstructive shock and death.
Localization (elevation) of PAP in cardiogenic associated with pulmonary hypertension, shock, hypotension and death
1) Confidence 0.66 Published 2008 Journal Vascular Health and Risk Management Section Body Doc Link PMC2605326 Disease Relevance 1.08 Pain Relevance 0
However, in some circumstances serious and prolonged elevation of PAP progresses to severe acute pulmonary hypertension, leading to life threatening complications including refractory systemic arterial hypotension, severe hypoxemia, right ventricular (RV) dysfunction and failure and ultimately resulting in cardiogenic and/or obstructive shock and death.
Localization (elevation) of PAP in cardiogenic associated with pulmonary hypertension, shock, hypotension and death
2) Confidence 0.66 Published 2008 Journal Vascular Health and Risk Management Section Body Doc Link PMC2605326 Disease Relevance 0.57 Pain Relevance 0
In addition, mutations of surfactant protein B gene and other known external or syndromic causes of PAP, including LPI, were ruled out in this cohort of paediatric patients.
Localization (causes) of PAP in external associated with pulmonary alveolar proteinosis
3) Confidence 0.29 Published 2007 Journal Orphanet J Rare Dis Section Body Doc Link PMC1845139 Disease Relevance 0.64 Pain Relevance 0
The limitations of the PAP immunocytochemical technique are also discussed in relation to the immunocytochemical localization of tyrosine hydroxylase and other antigens.
Localization (localization) of PAP
4) Confidence 0.09 Published 1979 Journal Fed. Proc. Section Abstract Doc Link 39006 Disease Relevance 0 Pain Relevance 0.33
In the eukaryotic expression system, the recombinant proPAP 1 and 2 were secreted into the media at a concentration of approximately 0.4 and 14.8 mg/liter, respectively.
Localization (secreted) of recombinant proPAP 1
5) Confidence 0.03 Published 2002 Journal J Insect Sci Section Body Doc Link PMC405832 Disease Relevance 0 Pain Relevance 0

General Comments

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