INT44901

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Context Info
Confidence 0.40
First Reported 1983
Last Reported 2010
Negated 0
Speculated 0
Reported most in Abstract
Documents 3
Total Number 3
Disease Relevance 0.55
Pain Relevance 0.09

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (EIF2S1) RNA binding (EIF2S1) nucleus (EIF2S1)
translation (EIF2S1) cytoplasm (EIF2S1)
EIF2S1 (Homo sapiens)
Pain Link Frequency Relevance Heat
Pain 2 88.00 High High
lidocaine 1 5.00 Very Low Very Low Very Low
anesthesia 1 5.00 Very Low Very Low Very Low
Inflammation 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Hypoxia 31 92.80 High High
Pain 2 88.00 High High
Ehrlich Tumor Carcinoma 2 75.00 Quite High
Frailty 1 29.36 Quite Low
Rheumatoid Arthritis 4 5.00 Very Low Very Low Very Low
Body Weight 2 5.00 Very Low Very Low Very Low
Stress 2 5.00 Very Low Very Low Very Low
Muscular Atrophy 1 5.00 Very Low Very Low Very Low
INFLAMMATION 1 5.00 Very Low Very Low Very Low
Altitude Sickness 1 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The protein expression and phosphorylation state of the eukaryotic translation initiation factor 2 alpha (eIF2?)
Gene_expression (expression) of eukaryotic translation initiation factor 2 alpha
1) Confidence 0.40 Published 2010 Journal PLoS ONE Section Body Doc Link PMC3004931 Disease Relevance 0.32 Pain Relevance 0
Formation of the ternary complex Met-tRNAi X eukaryotic initiation factor (eIF) 2 X GTP from eIF-2 X GDP requires exchange of GDP for GTP.
Gene_expression (Formation) of eIF-2
2) Confidence 0.24 Published 1983 Journal J. Biol. Chem. Section Abstract Doc Link 6553052 Disease Relevance 0.16 Pain Relevance 0.09
Furthermore, the inability of GEF to utilize eIF-2 (alpha P) X GDP explains how phosphorylation of eIF-2 can inhibit polypeptide chain initiation.
Gene_expression (utilize) of eIF-2
3) Confidence 0.24 Published 1983 Journal J. Biol. Chem. Section Abstract Doc Link 6553052 Disease Relevance 0.07 Pain Relevance 0

General Comments

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