INT44902

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Context Info
Confidence 0.28
First Reported 1983
Last Reported 1983
Negated 0
Speculated 0
Reported most in Abstract
Documents 1
Total Number 4
Disease Relevance 0.61
Pain Relevance 0.31

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (EIF2S1) RNA binding (EIF2S1) nucleus (EIF2S1)
translation (EIF2S1) cytoplasm (EIF2S1)
EIF2S1 (Homo sapiens)
Pain Link Frequency Relevance Heat
Pain 4 98.56 Very High Very High Very High
Disease Link Frequency Relevance Heat
Pain 4 98.56 Very High Very High Very High
Ehrlich Tumor Carcinoma 4 75.00 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
However, GDP is released rapidly from impure eIF-2 preparations, indicating the presence of a GDP/GTP exchange factor.
Localization (released) of eIF-2
1) Confidence 0.28 Published 1983 Journal J. Biol. Chem. Section Abstract Doc Link 6553052 Disease Relevance 0.17 Pain Relevance 0.10
However, at physiological Mg2+ concentrations, GDP is released from eIF-2 exceedingly slowly (Clemens, M.J., Pain, V.M., Wong, S.T., and Henshaw, E.C. (1982) Nature (Lond.) 296, 93-95).
Localization (released) of eIF-2 associated with pain
2) Confidence 0.28 Published 1983 Journal J. Biol. Chem. Section Abstract Doc Link 6553052 Disease Relevance 0.17 Pain Relevance 0.10
The factor also stimulated markedly the rate of ternary complex formation using eIF-2 X GDP as substrate with GTP and Met-tRNAi but not using phosphorylated eIF-2 X GDP as substrate. eIF-2 is released from the 80 S initiation complex with hydrolysis of GTP.
Localization (released) of eIF-2
3) Confidence 0.26 Published 1983 Journal J. Biol. Chem. Section Abstract Doc Link 6553052 Disease Relevance 0.13 Pain Relevance 0.06
If eIF-2 X GDP is actually the complex released, then GEF is absolutely required for eIF-2 to cycle and it is therefore a new eukaryotic initiation factor.
Localization (released) of eIF-2
4) Confidence 0.25 Published 1983 Journal J. Biol. Chem. Section Abstract Doc Link 6553052 Disease Relevance 0.13 Pain Relevance 0.06

General Comments

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