INT44916

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Context Info
Confidence 0.43
First Reported 1983
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 3
Total Number 3
Disease Relevance 1.60
Pain Relevance 0.33

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

isomerase activity (PTGDS) transport (PTGDS) extracellular space (PTGDS)
extracellular region (PTGDS) Golgi apparatus (PTGDS) nucleus (PTGDS)
PTGDS (Homo sapiens)
Pain Link Frequency Relevance Heat
dexamethasone 21 93.20 High High
corticosteroid 31 82.24 Quite High
cINOD 5 80.36 Quite High
COX-2 inhibitor 1 8.96 Low Low
Inflammation 37 5.00 Very Low Very Low Very Low
chemokine 23 5.00 Very Low Very Low Very Low
antagonist 10 5.00 Very Low Very Low Very Low
adenocard 8 5.00 Very Low Very Low Very Low
agonist 6 5.00 Very Low Very Low Very Low
cytokine 3 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Asthma 101 98.76 Very High Very High Very High
Carcinoma 7 97.20 Very High Very High Very High
Reprotox - General 1 7 91.80 High High
Cancer 119 89.96 High High
Apoptosis 3 87.92 High High
Occupational Lung Diseases 37 83.08 Quite High
Volume Depletion And Dehydration 1 81.52 Quite High
INFLAMMATION 40 80.12 Quite High
Nicotine Addiction 4 63.64 Quite High
Colon Cancer 21 11.24 Low Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
There was a significant negative trend between the doses (10(-7)-10(-3) M) of each of indomethacin, piroxicam, and ibuprofen, and the amounts of PGF2 alpha, PGE2, PGD2, and 15-keto-PGE2 produced.
Negative_regulation (amounts) of PGD2
1) Confidence 0.43 Published 1983 Journal J. Dent. Res. Section Abstract Doc Link 6576002 Disease Relevance 0.16 Pain Relevance 0.16
breakdown of PGD2 to sequential metabolites (Figure 1) may be required
Negative_regulation (breakdown) of PGD2
2) Confidence 0.22 Published 2008 Journal PPAR Research Section Body Doc Link PMC2528256 Disease Relevance 0.75 Pain Relevance 0
Other work also indicate that oral short-term treatment with prednisone does not inhibit the levels of the eicosanoids, PGD2, 5-HETE and LTE4, in BAL from asthmatic subjects at baseline or after allergen challenge [37].
Negative_regulation (inhibit) of PGD2 associated with asthma
3) Confidence 0.12 Published 2010 Journal Respir Res Section Body Doc Link PMC2894769 Disease Relevance 0.70 Pain Relevance 0.18

General Comments

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