INT44917

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Context Info
Confidence 0.50
First Reported 1983
Last Reported 2008
Negated 0
Speculated 1
Reported most in Abstract
Documents 6
Total Number 8
Disease Relevance 2.98
Pain Relevance 1.27

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

isomerase activity (PTGDS) transport (PTGDS) extracellular space (PTGDS)
extracellular region (PTGDS) Golgi apparatus (PTGDS) nucleus (PTGDS)
Anatomy Link Frequency
Notch 2
chondrocytes 2
megakaryocytes 2
HLMC 2
PTGDS (Homo sapiens)
Pain Link Frequency Relevance Heat
cINOD 11 99.88 Very High Very High Very High
cytokine 16 98.68 Very High Very High Very High
Osteoarthritis 141 95.80 Very High Very High Very High
aspirin 6 94.64 High High
Inflammation 71 92.48 High High
agonist 2 89.36 High High
Kinase C 1 83.24 Quite High
metalloproteinase 12 72.68 Quite High
Multiple sclerosis 3 49.44 Quite Low
Central nervous system 4 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
INFLAMMATION 83 99.76 Very High Very High Very High
Mastocytoma 2 97.96 Very High Very High Very High
Uterine Fibroids 72 95.94 Very High Very High Very High
Osteoarthritis 144 95.80 Very High Very High Very High
Rheumatoid Arthritis 23 91.12 High High
Apoptosis 18 85.16 High High
Body Weight 2 84.04 Quite High
Cancer 25 82.40 Quite High
Arrhythmias 2 Under Development 3 71.92 Quite High
Necrosis 3 70.44 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
These findings contrast with previous data showing that the Notch pathway downregulates L-PGDS expression in the brain-derived TE671 cells [37].
Negative_regulation (downregulates) of Gene_expression (expression) of L-PGDS in Notch
1) Confidence 0.50 Published 2008 Journal Arthritis Res Ther Section Body Doc Link PMC2656251 Disease Relevance 0.17 Pain Relevance 0.06
Knowledge about this structure of quaternary complex is useful for understanding the inhibitory mechanism of HQL-79 and should accelerate the structure-based development of novel anti-inflammatory drugs that inhibit PGD2 production specifically.
Negative_regulation (inhibit) of Gene_expression (production) of PGD2 associated with inflammation and cinod
2) Confidence 0.43 Published 2006 Journal J. Biol. Chem. Section Abstract Doc Link 16547010 Disease Relevance 0.35 Pain Relevance 0.14
There was a significant negative trend between the doses (10(-7)-10(-3) M) of each of indomethacin, piroxicam, and ibuprofen, and the amounts of PGF2 alpha, PGE2, PGD2, and 15-keto-PGE2 produced.
Negative_regulation (amounts) of Gene_expression (produced) of PGD2
3) Confidence 0.43 Published 1983 Journal J. Dent. Res. Section Abstract Doc Link 6576002 Disease Relevance 0.16 Pain Relevance 0.16
upregulated, whereas PGD2 downregulated, the expression of L-PGDS in cultured chondrocytes.
Negative_regulation (downregulated) of Gene_expression (expression) of L-PGDS in chondrocytes
4) Confidence 0.36 Published 2008 Journal Arthritis Res Ther Section Body Doc Link PMC2656251 Disease Relevance 0.51 Pain Relevance 0.22
Therefore, the increased expression of L-PGDS observed in our study may represent a compensatory mechanism to counter the reduced expression of PPAR?
Spec (may) Negative_regulation (represent) of Gene_expression (expression) of L-PGDS
5) Confidence 0.36 Published 2008 Journal Arthritis Res Ther Section Body Doc Link PMC2656251 Disease Relevance 0.77 Pain Relevance 0.35
HQL-79 selectively inhibited PGD2 production by H-PGDS-expressing human megakaryocytes and rat mastocytoma cells with an IC50 value of about 100 microm but only marginally affected the production of other prostanoids, suggesting the tight functional engagement between H-PGDS and cyclooxygenase.
Negative_regulation (inhibited) of Gene_expression (production) of PGD2 in megakaryocytes associated with mastocytoma
6) Confidence 0.32 Published 2006 Journal J. Biol. Chem. Section Abstract Doc Link 16547010 Disease Relevance 0.30 Pain Relevance 0.06
NIM (10(-6) to 10(-3) M) markedly inhibited the de novo synthesis of LTC4 from basophils, LTC4 and PGD2 from HLMC and PGD2 from HSMC.
Negative_regulation (inhibited) of Gene_expression (synthesis) of PGD2 in HLMC
7) Confidence 0.29 Published 1993 Journal J. Pharmacol. Exp. Ther. Section Abstract Doc Link 7505332 Disease Relevance 0.07 Pain Relevance 0.28
signaling, thought to inhibit fibroid growth and survival, at two points in the PPAR pathway: 1) through increased ANXA1 gene expression which can inhibit phospholipase A2 activity and in turn decrease arachidonic acid synthesis, and 2) by decreasing L-PGDS expression which would reduce synthesis of PGJ2, an endogenous ligand for PPAR?.
Negative_regulation (decreasing) of Gene_expression (expression) of L-PGDS associated with uterine fibroids
8) Confidence 0.18 Published 2007 Journal BMC Womens Health Section Abstract Doc Link PMC1852551 Disease Relevance 0.65 Pain Relevance 0

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