INT44920

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Context Info
Confidence 0.41
First Reported 1983
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 18
Total Number 18
Disease Relevance 9.90
Pain Relevance 7.16

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (IK) nucleus (IK) cell-cell signaling (IK)
Anatomy Link Frequency
macrophage 1
blood 1
mast cells 1
urine 1
IK (Homo sapiens)
Pain Link Frequency Relevance Heat
cytokine 322 100.00 Very High Very High Very High
Opioid 6 99.98 Very High Very High Very High
chemokine 111 99.80 Very High Very High Very High
agonist 104 99.80 Very High Very High Very High
Infliximab 15 99.76 Very High Very High Very High
Kappa opioid receptor 6 99.36 Very High Very High Very High
antagonist 91 99.14 Very High Very High Very High
Inflammation 263 98.88 Very High Very High Very High
Action potential 60 98.40 Very High Very High Very High
rheumatoid arthritis 148 97.44 Very High Very High Very High
Disease Link Frequency Relevance Heat
Asthma 630 99.64 Very High Very High Very High
Toxicity 14 99.64 Very High Very High Very High
Disease 74 99.38 Very High Very High Very High
Hypersensitivity 25 99.28 Very High Very High Very High
INFLAMMATION 278 98.88 Very High Very High Very High
Rhinitis 29 98.24 Very High Very High Very High
Bordatella Infection 6 97.92 Very High Very High Very High
Gastroenteritis 6 97.84 Very High Very High Very High
Rheumatoid Arthritis 148 97.44 Very High Very High Very High
Cancer 85 97.40 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Plumbism was diagnosed by the determination of blood and urine lead levels and in two of the families by the decrease of red cell delta-aminolevulinic acid dehydratase activity.
Negative_regulation (decrease) of red in urine
1) Confidence 0.41 Published 1983 Journal Arch. Toxicol. Suppl. Section Abstract Doc Link 6578733 Disease Relevance 0.49 Pain Relevance 0.16
Plumbism was diagnosed by the determination of blood and urine lead levels and in two of the families by the decrease of red cell delta-aminolevulinic acid dehydratase activity.
Negative_regulation (decrease) of red in blood
2) Confidence 0.14 Published 1983 Journal Arch. Toxicol. Suppl. Section Abstract Doc Link 6578733 Disease Relevance 0.49 Pain Relevance 0.16
These results suggest that opioid suppression of IK is mediated by kappa-opioid receptors coupled to a pertussis toxin-insensitive G-protein.
Negative_regulation (suppression) of IK associated with bordatella infection, kappa opioid receptor and opioid
3) Confidence 0.12 Published 1995 Journal J. Pharmacol. Exp. Ther. Section Abstract Doc Link 7752097 Disease Relevance 0.20 Pain Relevance 0.81
Kappa agonist-mediated IK reduction was prevented by intracellular dialysis with an inactive form of guanosine diphosphate, guanosine 5'-O-(2-thio)diphosphate (100-200 microM; n = 10) but was unchanged by incubation with pertussis toxin (500 ng/ml, 24-48 h, n = 10).
Negative_regulation (reduction) of IK associated with bordatella infection and agonist
4) Confidence 0.08 Published 1995 Journal J. Pharmacol. Exp. Ther. Section Abstract Doc Link 7752097 Disease Relevance 0.09 Pain Relevance 0.88
However, the kappa-selective agonist trans-(+/-)-3,4-dichloro-N-methyl-N-(2-[1-pyrrolidinyl]cyclohexyl)ben zene-acetamide reduced IK in a concentration-dependent manner (EC50 = 2.3 microM, maximum inhibition 44%, n = 40).
Negative_regulation (reduced) of IK associated with agonist
5) Confidence 0.08 Published 1995 Journal J. Pharmacol. Exp. Ther. Section Abstract Doc Link 7752097 Disease Relevance 0.06 Pain Relevance 0.90
Thus, full activation of the IK,CCh and complete inhibition of the ICa are not needed to produce strong AP shortening and a negative inotropic response.
Negative_regulation (inhibition) of IK associated with action potential
6) Confidence 0.03 Published 2010 Journal BMC Physiol Section Body Doc Link PMC2894799 Disease Relevance 0.07 Pain Relevance 0.26
Oil Red O absorbance levels were also reduced 8.7-fold (p<0.002, Fig. 4I).
Negative_regulation (reduced) of Oil Red O
7) Confidence 0.03 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2581599 Disease Relevance 0 Pain Relevance 0
Contribution of ICa inhibition to negative inotropic effect of CCh in intact sinoatrial preparations was tested by specifically inhibiting ICa (without activating IK,CCh) to the extent it is reduced (~30%) under the maximally effective CCh concentration (10-7 M).
Negative_regulation (inhibiting) of IK
8) Confidence 0.02 Published 2010 Journal BMC Physiol Section Body Doc Link PMC2894799 Disease Relevance 0 Pain Relevance 0.07
These results demonstrated that BCE has an anti-allergic potential and it may be due to the inhibition of histamine release and cytokine gene expression in the mast cells.
Negative_regulation (inhibition) of cytokine gene in mast cells associated with hypersensitivity and cytokine
9) Confidence 0.01 Published 2004 Journal Immunopharmacol Immunotoxicol Section Abstract Doc Link 15209365 Disease Relevance 0.64 Pain Relevance 0.15
release was predominantly mediated by CB2R, since cytokine suppression was not significantly reversed by the CB1R antagonist SR1.
Negative_regulation (suppression) of cytokine associated with antagonist and cytokine
10) Confidence 0.01 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2809084 Disease Relevance 0.13 Pain Relevance 0.26
Further, negative PCR results to any of the IS elements in the algorithm should also be verified by sequencing the region to ensure that mutations or deletions in primer binding regions are not at fault and that the IS element is truly lacking from this region.
Negative_regulation (lacking) of IS element
11) Confidence 0.01 Published 2007 Journal BMC Microbiol Section Body Doc Link PMC2104537 Disease Relevance 0.05 Pain Relevance 0
Therefore, the activated HPA axis in depressed patients seems to suppress the activity of the cytokine system.
Negative_regulation (suppress) of cytokine associated with cytokine
12) Confidence 0.01 Published 2008 Journal Current Neuropharmacology Section Body Doc Link PMC2687935 Disease Relevance 1.06 Pain Relevance 0.99
Part of the anti-inflammatory activity of glucocorticoids in asthma may also involve reduction in macrophage and resident cell eicosanoid (leukotriene B4 and thromboxane B2) and cytokine and chemokine (e.g.
Negative_regulation (reduction) of cytokine in macrophage associated with asthma, chemokine, inflammation and cytokine
13) Confidence 0.01 Published 2008 Journal J Occup Med Toxicol Section Body Doc Link PMC2259400 Disease Relevance 1.02 Pain Relevance 0.24
This approach has the potential advantage of suppressing the expression of various proinflammatory Th2 cytokines simultaneously rather than suppressing the activity of a single cytokine.


Negative_regulation (suppressing) of cytokine associated with cytokine
14) Confidence 0.01 Published 2008 Journal J Occup Med Toxicol Section Body Doc Link PMC2259400 Disease Relevance 0.96 Pain Relevance 0.13
inhibitors have been the subject of much interest because of their demonstrated efficacy in disease improvement compared to other cytokine inhibitors.


Negative_regulation (inhibitors) of cytokine associated with disease and cytokine
15) Confidence 0.01 Published 2008 Journal Indian Journal of Pharmacology Section Body Doc Link PMC2792605 Disease Relevance 1.28 Pain Relevance 0.73
A pair of human cytokine microarrays including 16 chemokine receptors and 33 chemokines was hybridized with labelled cDNA probes prepared from mRNAs obtained from RA and non-RA pools of synovial RNA.
Negative_regulation (pair) of cytokine associated with chemokine, rheumatoid arthritis and cytokine
16) Confidence 0.01 Published 2005 Journal Arthritis Res Ther Section Body Doc Link PMC1065316 Disease Relevance 1.22 Pain Relevance 0.87
Although several studies using animal models suggest that pentoxifylline is able to decrease the cytokine induced toxicity of antineoplastic agents while preserving anti-tumor treatment efficacy.36 Clinical studies have shown that the drug failed to improve appetite or increase the weight of cachectic patients,37 and patients in the study frequently reported gastrointestinal side effects.
Negative_regulation (decrease) of cytokine associated with toxicity, cancer and cytokine
17) Confidence 0.00 Published 2010 Journal Cancer management and research Section Body Doc Link PMC3004581 Disease Relevance 0.66 Pain Relevance 0.21
Promising new drugs for eosinophilic gastroenteritis include montelukast, a selective leukotriene receptor antagonist, and suplaplast tosilate, a selective Th2 cytokine inhibitor with inhibitory effects on allergy-induced eosinophilic infiltration and IgE production.
Negative_regulation (inhibitor) of cytokine associated with rhinitis, antagonist, hypersensitivity, gastroenteritis and cytokine
18) Confidence 0.00 Published 2002 Journal Curr Gastroenterol Rep Section Abstract Doc Link 12228038 Disease Relevance 1.48 Pain Relevance 0.36

General Comments

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