INT4494

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Context Info
Confidence 0.45
First Reported 1975
Last Reported 2010
Negated 12
Speculated 2
Reported most in Abstract
Documents 41
Total Number 43
Disease Relevance 18.38
Pain Relevance 9.68

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cell proliferation (GCG) signal transduction (GCG) extracellular space (GCG)
small molecule metabolic process (GCG) extracellular region (GCG) plasma membrane (GCG)
Anatomy Link Frequency
plasma 13
ureter 1
endocrine cells 1
central nervous system 1
blood 1
GCG (Homo sapiens)
Pain Link Frequency Relevance Heat
Somatostatin 118 100.00 Very High Very High Very High
Catecholamine 37 100.00 Very High Very High Very High
Serotonin 16 100.00 Very High Very High Very High
Neuropeptide 6 100.00 Very High Very High Very High
anesthesia 6 100.00 Very High Very High Very High
narcan 47 99.98 Very High Very High Very High
opiate 16 99.44 Very High Very High Very High
Chronic pancreatitis 6 99.28 Very High Very High Very High
tolerance 15 99.20 Very High Very High Very High
Central nervous system 2 99.20 Very High Very High Very High
Disease Link Frequency Relevance Heat
Hypoglycemia 551 99.96 Very High Very High Very High
Cancer 95 99.76 Very High Very High Very High
Diabetes Mellitus 456 99.60 Very High Very High Very High
Pancreatitis 14 99.28 Very High Very High Very High
Impaired Glucose Tolerance 14 99.20 Very High Very High Very High
Obesity 71 99.04 Very High Very High Very High
Reprotox - General 1 9 98.36 Very High Very High Very High
Overnutrition 2 96.52 Very High Very High Very High
Cholestasis 1 95.88 Very High Very High Very High
Cystitis 1 95.40 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The action of glucagon and commonly used antispasmodics and analgesics on the canine ureter.
Regulation (action) of glucagon in ureter associated with analgesic
1) Confidence 0.45 Published 1983 Journal Br J Surg Section Title Doc Link 6130814 Disease Relevance 0.17 Pain Relevance 0.36
Effect of pramlintide on symptom, catecholamine, and glucagon responses to hypoglycemia in healthy subjects.
Regulation (Effect) of glucagon associated with hypoglycemia and catecholamine
2) Confidence 0.44 Published 2004 Journal Metab. Clin. Exp. Section Title Doc Link 15334389 Disease Relevance 0.43 Pain Relevance 0.15
These results showed that pramlintide did not impair the symptom, catecholamine, and glucagon responses to insulin-induced hypoglycemia in healthy subjects.
Regulation (responses) of glucagon associated with hypoglycemia and catecholamine
3) Confidence 0.44 Published 2004 Journal Metab. Clin. Exp. Section Abstract Doc Link 15334389 Disease Relevance 0.33 Pain Relevance 0.24
To further test the effect of pramlintide on symptom, catecholamine, and glucagon responses, a 3-step hypoglycemic clamp was investigated in healthy volunteers.
Regulation (effect) of glucagon associated with catecholamine
4) Confidence 0.44 Published 2004 Journal Metab. Clin. Exp. Section Abstract Doc Link 15334389 Disease Relevance 0.26 Pain Relevance 0.09
The influence of barbiturates and glucagon on cardiac function is discussed.
Regulation (influence) of glucagon
5) Confidence 0.44 Published 1975 Journal Acta Anaesthesiol Scand Section Abstract Doc Link 1181807 Disease Relevance 0.09 Pain Relevance 0.05
There was a significant rise in pancreatic polypeptide compared to a control infusion, but no change in plasma insulin, pancreatic glucagon, gastrin, somatostatin, motilin, neurotensin, gastric inhibitory peptide, or cholecystokinin was seen.
Neg (no) Regulation (change) of glucagon in plasma associated with somatostatin and cholecystokinin
6) Confidence 0.40 Published 1984 Journal Clin. Endocrinol. (Oxf) Section Abstract Doc Link 6147213 Disease Relevance 0 Pain Relevance 0.19
The present studies were undertaken to characterize further the influence of synthetic human beta-endorphin (0.5 mg/h) on insulin and glucagon responses to intravenous glucose in humans.
Regulation (responses) of glucagon
7) Confidence 0.39 Published 1989 Journal Am. J. Physiol. Section Abstract Doc Link 2551176 Disease Relevance 0.08 Pain Relevance 0
Plasma insulin, C-peptide, pancreatic polypeptide, counterregulatory hormone, glucagon, adrenaline, norepinephrine, glycerol, ?
Regulation (glycerol) of glucagon in Plasma
8) Confidence 0.37 Published 2008 Journal Diabetes Section Body Doc Link PMC2453632 Disease Relevance 0.77 Pain Relevance 0.06
To resolve existing controversies about the impact of the menstrual cycle on oral glucose tolerance, we examined the glucose, insulin, and glucagon responses to an oral glucose challenge at different phases of the menstrual cycle in five normal women (NW) and six women with premenstrual syndrome and alleged premenstrual hypoglycemic attacks (PMHA).
Spec (examined) Regulation (responses) of glucagon associated with dismenorea, tolerance and impaired glucose tolerance
9) Confidence 0.37 Published 1986 Journal J. Clin. Endocrinol. Metab. Section Abstract Doc Link 3517030 Disease Relevance 0.27 Pain Relevance 0.31
Concomitant infusion of naloxone altered neither the basal concentrations of glucose, insulin, and glucagon nor the responses of these measures to the glucose challenge.
Neg (nor) Regulation (responses) of glucagon associated with narcan
10) Confidence 0.37 Published 1986 Journal J. Clin. Endocrinol. Metab. Section Abstract Doc Link 3517030 Disease Relevance 0.47 Pain Relevance 0.53
Mucosal endocrine cells immunoreactive for somatostatin, peptide YY, and glucagon were also examined.
Regulation (immunoreactive) of glucagon in endocrine cells associated with somatostatin
11) Confidence 0.35 Published 1994 Journal Dig. Dis. Sci. Section Abstract Doc Link 7956615 Disease Relevance 0 Pain Relevance 0.34
In general, insulin is the hormone responsible for glucose disposal, glucagon for glucose availability.
Regulation (responsible) of glucagon
12) Confidence 0.29 Published 2008 Journal Vascular Health and Risk Management Section Body Doc Link PMC2597758 Disease Relevance 0.15 Pain Relevance 0
Naloxone (5 mg), an opiate antagonist, did not produce any significant change in the insulin and glucagon responses to beta-endorphin, while somatostatin (0.25 mg/h) completely abolished the hormonal responses to the opioid.
Regulation (responses) of glucagon associated with antagonist, somatostatin, narcan, opiate and opioid
13) Confidence 0.28 Published 1987 Journal Diabete Metab Section Abstract Doc Link 2896134 Disease Relevance 0.37 Pain Relevance 0.58
The regulation of insulin and glucagon secretion by opiates: a study with naloxone in healthy humans.
Regulation (regulation) of glucagon associated with narcan and opiate
14) Confidence 0.28 Published 1985 Journal Acta Diabetol Lat Section Title Doc Link 3890450 Disease Relevance 0 Pain Relevance 0.72
In contrast, both allo- and autograft recipients had glucagon responses to intravenous arginine.
Regulation (responses) of glucagon
15) Confidence 0.27 Published 1997 Journal Diabetes Section Abstract Doc Link 8971076 Disease Relevance 0.51 Pain Relevance 0
Concomitant infusion of naloxone altered neither the basal concentrations of glucose, insulin, and glucagon nor the responses of these measures to the glucose challenge.
Neg (neither) Regulation (altered) of glucagon associated with narcan
16) Confidence 0.27 Published 1986 Journal J. Clin. Endocrinol. Metab. Section Abstract Doc Link 3517030 Disease Relevance 0.47 Pain Relevance 0.53
Influence of glucagon on systolic time intervals during induction of anaesthesia with barbiturate.
Regulation (Influence) of glucagon associated with anesthesia
17) Confidence 0.26 Published 1975 Journal Acta Anaesthesiol Scand Section Title Doc Link 1181807 Disease Relevance 0.07 Pain Relevance 0.14
Although insulin and glucagon responses in patients with chronic pancreatitis tended to be lower than those in normal subjects, the differences between the two groups were not statistically significant.
Regulation (responses) of glucagon associated with chronic pancreatitis
18) Confidence 0.26 Published 1982 Journal Endocrinol. Jpn. Section Abstract Doc Link 6763560 Disease Relevance 0.79 Pain Relevance 0.42
Naloxone had no significant effect upon blood pressure, heart rate, plasma insulin, glucagon or norepinephrine.
Neg (no) Regulation (effect) of glucagon in heart associated with narcan
19) Confidence 0.25 Published 1984 Journal Acta Endocrinol. Section Abstract Doc Link 6331037 Disease Relevance 0 Pain Relevance 0.49
Since naloxone did not modify plasma levels of insulin and glucagon, an indirect effect of naloxone on adrenal medullary secretion seems to be excluded.
Neg (not) Regulation (modify) of glucagon in plasma associated with narcan
20) Confidence 0.25 Published 1984 Journal Acta Endocrinol. Section Abstract Doc Link 6331037 Disease Relevance 0 Pain Relevance 0.50

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