INT44942

Context Info Confidence 0.49 First Reported 1984 Last Reported 2010 Negated 0 Speculated 0 Reported most in Body Documents 5 Total Number 5 Disease Relevance 4.18 Pain Relevance 0.31

small molecule metabolic process (HSD11B1) oxidoreductase activity (HSD11B1) endoplasmic reticulum (HSD11B1)

Anatomy Link Frequency blood 2 kidney 2 HSD11B1 (Homo sapiens)

Pain Link Frequency Relevance Heat Inflammation 31 99.12 Angina 6 75.00 Potency 3 54.16 Bile 18 47.20 Paracetamol 2 39.84 Kinase C 1 31.60 nud 4 13.56 withdrawal 6 5.00 peptic ulcer disease 6 5.00 cytokine 5 5.00

Disease Link Frequency Relevance Heat Disorder Of Lipid Metabolism 112 100.00 INFLAMMATION 37 99.12 Liver Disease 1 98.80 Feminization 1 98.46 Virilism 1 98.18 Renal Disease 18 94.08 Aggression 1 91.32 Metabolic Syndrome 4 82.60 Disease 16 82.00 Diabetes Mellitus 16 81.68

Sentences Mentioned In

Key:

Protein

Mutation

Event

Anatomy

Negation

Speculation

Pain term

Disease term

In the HDL fraction HDL2 decreased insignificantly but HDL3 cholesterol increased by 12%, p less than 0.05.

Positive_regulation (increased) of Localization (decreased) of HDL associated with disorder of lipid metabolism

1) Confidence 0.49 Published 1984 Journal Acta Med. Scand. Suppl. Section Abstract Doc Link 6587755 Disease Relevance 0.56 Pain Relevance 0.15

The HDL-C increase produced by fibrates is due not only to the reduction in triglycerides, but also secondary to stimulation of PPAR-?

Positive_regulation (stimulation) of Localization (secondary) of HDL associated with disorder of lipid metabolism

2) Confidence 0.49 Published 2005 Journal Vascular Health and Risk Management Section Body Doc Link PMC1993967 Disease Relevance 0.68 Pain Relevance 0

The HDL-C increase produced by fibrates is due not only to the reduction in triglycerides, but also secondary to stimulation of PPAR-?

Positive_regulation (increase) of Localization (secondary) of HDL associated with disorder of lipid metabolism

3) Confidence 0.49 Published 2005 Journal Vascular Health and Risk Management Section Body Doc Link PMC1993967 Disease Relevance 0.67 Pain Relevance 0

As shown by de Beer and colleagues, sPLA2-IIA dependent hydrolysis of HDL results in a more efficient scavenger receptor class B type I cholesteryl ester uptake, leading to an accelerated HDL catabolism in the kidney during inflammatory states (deBeer et al 2000).

Positive_regulation (accelerated) of Localization (catabolism) of HDL in kidney associated with inflammation and disorder of lipid metabolism

4) Confidence 0.08 Published 2008 Journal Vascular Health and Risk Management Section Body Doc Link PMC2515419 Disease Relevance 1.01 Pain Relevance 0.16

Chronic use of AASs has been known to cause serious adverse effects such as virilization, feminization, liver disorders, neuropsychiatric disorders, adverse blood lipid profiles (increased LDL and decreased HDL), cardiovascular disorders and renal complications [26-28].

Positive_regulation (increased) of Localization (decreased) of HDL in blood associated with liver disease, feminization, disorder of lipid metabolism and virilism

5) Confidence 0.06 Published 2010 Journal Subst Abuse Treat Prev Policy Section Body Doc Link PMC2877023 Disease Relevance 0.83 Pain Relevance 0

General Comments

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