INT44944

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Context Info
Confidence 0.24
First Reported 1984
Last Reported 2010
Negated 2
Speculated 1
Reported most in Body
Documents 9
Total Number 10
Disease Relevance 5.85
Pain Relevance 3.33

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

Anatomy Link Frequency
uterine 2
MRXS5 (Homo sapiens)
Pain Link Frequency Relevance Heat
tolerance 1 99.76 Very High Very High Very High
Inflammation 184 99.38 Very High Very High Very High
Paracetamol 2 99.22 Very High Very High Very High
cINOD 28 99.20 Very High Very High Very High
cva 2 94.68 High High
midbrain 4 94.32 High High
COX-2 inhibitor 13 93.76 High High
Abeta 5 92.44 High High
Inflammatory stimuli 7 92.40 High High
Inflammatory mediators 25 92.20 High High
Disease Link Frequency Relevance Heat
INFLAMMATION 243 99.38 Very High Very High Very High
Alzheimer's Dementia 4 98.80 Very High Very High Very High
Hemorrhage 1 94.68 High High
Cv General 3 Under Development 1 92.84 High High
Cancer 76 92.64 High High
Ulcers 3 88.40 High High
Hypertrophy 4 87.20 High High
Hyperplasia 4 86.44 High High
Asthma 43 86.16 High High
Duodenal Ulcer 2 86.08 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
In contrast, carprofen, a novel NOSAC with good antiinflammatory properties and gastric tolerance, failed to affect mucosal generation of PGs and did not influence gastric mucosal integrity.
Neg (failed) Regulation (affect) of Gene_expression (generation) of PGs associated with inflammation and tolerance
1) Confidence 0.24 Published 1984 Journal Scand. J. Gastroenterol. Suppl. Section Abstract Doc Link 6588526 Disease Relevance 0.76 Pain Relevance 0.25
In contrast, paracetamol or carprofen, a novel NOSAC, fails to affect mucosal generation of PGs and does not influence gastric mucosal integrity.
Neg (fails) Regulation (affect) of Gene_expression (generation) of PGs associated with paracetamol
2) Confidence 0.24 Published 1984 Journal Scand. J. Gastroenterol. Suppl. Section Abstract Doc Link 6599541 Disease Relevance 0.58 Pain Relevance 0.27
Single-target inhibitors cannot achieve full success in anti-inflammatory treatment because they cannot control the production of both LTs and PGs at the same time.
Regulation (control) of Gene_expression (production) of PGs associated with inflammation
3) Confidence 0.15 Published 2007 Journal PLoS Computational Biology Section Body Doc Link PMC1829479 Disease Relevance 0.53 Pain Relevance 0.40
The potential role of astroglial cells in the phagocytosis of amyloid and the involvement of PGs in this process suggests that a modulation of PGs synthesis may be a putative target in the prevention of amyloid deposition.
Regulation (modulation) of Gene_expression (synthesis) of PGs associated with alzheimer's dementia
4) Confidence 0.08 Published 2006 Journal Neurochem. Int. Section Abstract Doc Link 16546299 Disease Relevance 0.56 Pain Relevance 0.71
Its expression remains constant under either physiological or pathological conditions controlling synthesis of those PGs primarily involved in the regulation of homeostatic functions.
Regulation (controlling) of Gene_expression (synthesis) of PGs
5) Confidence 0.06 Published 2002 Journal Biomed. Pharmacother. Section Abstract Doc Link 12199620 Disease Relevance 0.40 Pain Relevance 0.15
COX-1 is the constitutively expressed isoform involved in the production of PGs under physiological conditions.
Regulation (involved) of Gene_expression (production) of PGs
6) Confidence 0.04 Published 2002 Journal Respir Res Section Body Doc Link PMC64809 Disease Relevance 0.88 Pain Relevance 0.38
targeting the COX-2 inducible production of PGs.
Regulation (targeting) of Gene_expression (production) of PGs
7) Confidence 0.04 Published 2008 Journal PPAR Research Section Body Doc Link PMC2490577 Disease Relevance 1.56 Pain Relevance 0.94
Thus, a combination of changes in luteal production of luteotropic and luteolytic PGs and changes in the responsiveness of luteal tissue to these PGs may play a role in controlling luteal function in various species.


Regulation (changes) of Gene_expression (production) of PGs
8) Confidence 0.01 Published 2003 Journal Reprod Biol Endocrinol Section Body Doc Link PMC293427 Disease Relevance 0 Pain Relevance 0
Together, the data indicate that uterine PG production is regulated, at least in part, by the expression and activity of PLA2 enzymes and that specific PLA2 isotypes may regulate the production of specific PGs.


Spec (may) Regulation (regulate) of Gene_expression (production) of PGs in uterine
9) Confidence 0.01 Published 2007 Journal Reprod Biol Endocrinol Section Body Doc Link PMC1868772 Disease Relevance 0.07 Pain Relevance 0
These data suggest that overexpression of HO-1 exerts an inhibitory effect on COX-2 expression and PGs production in different cell types.
Regulation (effect) of Gene_expression (production) of PGs
10) Confidence 0.00 Published 2010 Journal J Neuroinflammation Section Body Doc Link PMC3002338 Disease Relevance 0.51 Pain Relevance 0.23

General Comments

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