INT44955

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Context Info
Confidence 0.42
First Reported 1984
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 8
Total Number 8
Disease Relevance 3.79
Pain Relevance 0.83

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

mitochondrion (Eln) extracellular region (Eln) proteinaceous extracellular matrix (Eln)
extracellular matrix organization (Eln)
Anatomy Link Frequency
ligaments 1
blood 1
aorta 1
vessels 1
Eln (Rattus norvegicus)
Pain Link Frequency Relevance Heat
carpal tunnel syndrome 5 97.72 Very High Very High Very High
Inflammation 6 92.04 High High
Action potential 58 80.48 Quite High
dexamethasone 48 78.16 Quite High
Snapping jaw 1 75.00 Quite High
corticosteroid 8 59.48 Quite High
metalloproteinase 9 53.84 Quite High
Pain 4 36.16 Quite Low
fibrosis 4 6.40 Low Low
Nerve growth factor 1 6.36 Low Low
Disease Link Frequency Relevance Heat
Disease 4 98.52 Very High Very High Very High
Carpal Tunnel Syndrome 7 97.72 Very High Very High Very High
Hypertrophy 13 97.56 Very High Very High Very High
Obesity 6 96.72 Very High Very High Very High
Aneurism 19 95.84 Very High Very High Very High
Rheumatoid Arthritis 46 93.68 High High
INFLAMMATION 5 92.04 High High
Injury 20 89.88 High High
Cadaver 1 89.28 High High
Abdominal Aortic Aneurysm 37 87.72 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
There was a decreased amount of elastin in the blood vessel walls and around the vessels in the CTS patients as well.
Negative_regulation (decreased) of elastin in vessels associated with carpal tunnel syndrome
1) Confidence 0.42 Published 2004 Journal J. Orthop. Res. Section Abstract Doc Link 15475214 Disease Relevance 0.81 Pain Relevance 0.44
Some indications that this tissue is undergoing adaptive changes include the presence of thickened arterial walls suggesting a decreased blood flow and the tendency for decreased amounts of elastin to be associated with denser-appearing collagen.
Negative_regulation (decreased) of elastin in blood
2) Confidence 0.28 Published 1984 Journal Oral Surg. Oral Med. Oral Pathol. Section Abstract Doc Link 6593661 Disease Relevance 0.25 Pain Relevance 0.16
As in the case of the collagen mRNAs, there was an age-dependent decrease in elastin mRNA (Fig. 7A).
Negative_regulation (decrease) of elastin mRNA
3) Confidence 0.13 Published 2010 Journal Journal of Molecular and Cellular Cardiology Section Body Doc Link PMC2845824 Disease Relevance 0.32 Pain Relevance 0.05
52% downregulation of gene responsible for elastin).
Negative_regulation (downregulation) of elastin
4) Confidence 0.13 Published 2010 Journal Journal of Molecular and Cellular Cardiology Section Abstract Doc Link PMC2845824 Disease Relevance 0.40 Pain Relevance 0.08
Indeed, deletion or inhibition of RAR results in reduced elastin and alveolar simplification [40,41].
Negative_regulation (reduced) of elastin
5) Confidence 0.04 Published 2009 Journal Respir Res Section Body Doc Link PMC2739515 Disease Relevance 0.44 Pain Relevance 0.10
Patients such as this with extensive aneurysmal disease clearly have arterial walls that are relatively easily traumatised, with defective collagen and elastin.
Negative_regulation (defective) of elastin associated with disease
6) Confidence 0.03 Published 2007 Journal BMC Surg Section Body Doc Link PMC1851946 Disease Relevance 0.41 Pain Relevance 0
Similarly, transfer of IGF-1 cDNA by using an adenovirus vector led to the synthesis and deposition of increased amounts of types I and III collagen, elastin, tenascin, and vimentin in the same model[111]; thus confirming the potential of using vector-laden hydrogels for the in situ delivery of genes to damaged ligaments for potential biological repair of the ACL.


Negative_regulation (amounts) of elastin in ligaments
7) Confidence 0.02 Published 2010 Journal Sports Med Arthrosc Rehabil Ther Technol Section Body Doc Link PMC2879239 Disease Relevance 0.07 Pain Relevance 0
MacSweeney et al. [38] also indicated that the increasing aneurysmal aorta stiffness was associated with the loss of elastin.
Negative_regulation (loss) of elastin in aorta
8) Confidence 0.02 Published 2006 Journal Biomed Eng Online Section Body Doc Link PMC1421417 Disease Relevance 1.09 Pain Relevance 0

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