INT44972

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Context Info
Confidence 0.58
First Reported 1984
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 16
Total Number 16
Disease Relevance 10.17
Pain Relevance 0.93

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

plasma membrane (Gfra1)
Anatomy Link Frequency
urine 3
frontal cortex 2
nerve 1
bladder 1
kidney 1
Gfra1 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
interstitial cystitis 1 93.24 High High
Catecholamine 1 90.12 High High
anesthesia 6 87.32 High High
Neuropeptide 5 86.80 High High
tolerance 12 86.72 High High
algil 1 83.36 Quite High
Inflammation 42 80.16 Quite High
Eae 16 80.04 Quite High
fibrosis 9 78.40 Quite High
ischemia 1 75.40 Quite High
Disease Link Frequency Relevance Heat
Injury 50 99.90 Very High Very High Very High
Disease 5 99.90 Very High Very High Very High
Hypothermia 6 99.66 Very High Very High Very High
Overactive Bladder 47 99.56 Very High Very High Very High
Natriuresis 2 99.42 Very High Very High Very High
Acid Base Imbalance 272 99.36 Very High Very High Very High
Renal Disease 16 99.12 Very High Very High Very High
Chronic Renal Failure 380 98.60 Very High Very High Very High
Increased Venous Pressure Under Development 5 97.56 Very High Very High Very High
Pneumoperitoneum 8 94.48 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The pre-treatment with L-N-nitric arginine methylester (10 mg/kg), the expressions of GDNF and GDNFR-beta in the spinal cord, both GDNFR-alpha and GDNFR-beta in the frontal cortex were decreased.
Negative_regulation (decreased) of GDNFR-alpha in frontal cortex
1) Confidence 0.58 Published 2000 Journal Zhonghua Yi Xue Za Zhi Section Body Doc Link 11798749 Disease Relevance 0.13 Pain Relevance 0
The pre-treatment with L-N-nitric arginine methylester (10 mg/kg), the expressions of GDNF and GDNFR-beta in the spinal cord, both GDNFR-alpha and GDNFR-beta in the frontal cortex were decreased.
Negative_regulation (decreased) of GDNFR-beta in frontal cortex
2) Confidence 0.58 Published 2000 Journal Zhonghua Yi Xue Za Zhi Section Body Doc Link 11798749 Disease Relevance 0.13 Pain Relevance 0
In Inactin anaesthetized rats, hypothermia at 28 degrees C decreased GFR by 50% but failed to alter efferent renal sympathetic nerve activity (ERSNA).
Negative_regulation (decreased) of GFR in nerve associated with hypothermia
3) Confidence 0.38 Published 1998 Journal Acta Physiol. Scand. Section Abstract Doc Link 9715736 Disease Relevance 0.70 Pain Relevance 0.13
There is the simultaneous down-regulation of genes for a number of neurotrophic factor receptors (Gfra3, Gfra2, Gfra1, Ntrk1, and Adcyap1r1).
Negative_regulation (number) of Gfra1
4) Confidence 0.30 Published 2010 Journal BMC Neurosci Section Body Doc Link PMC3001741 Disease Relevance 0.32 Pain Relevance 0.04
On the other hand, BSSB (50 mg/kg) induced a large reversible decrease of GFR as well as a decrease of urine excretion.
Negative_regulation (decrease) of GFR in urine
5) Confidence 0.29 Published 1997 Journal Methods Find Exp Clin Pharmacol Section Abstract Doc Link 9442480 Disease Relevance 0.24 Pain Relevance 0.09
An increase in urine production was the dominant effect (up to 200% of the initial value), with the alterations of GFR and RPF being of minor significance except in one patient with a GFR reduction up to almost 50% the original value.
Negative_regulation (reduction) of GFR in urine
6) Confidence 0.29 Published 1997 Journal Methods Find Exp Clin Pharmacol Section Abstract Doc Link 9442480 Disease Relevance 0.22 Pain Relevance 0.07
Treatment of hypovolemic rats with flosulide (5-25 mg/kg) or indomethacin 10 mg/kg reduced RPF and GFR.
Negative_regulation (reduced) of GFR
7) Confidence 0.18 Published 2001 Journal Inflammation Section Abstract Doc Link 11321358 Disease Relevance 0.37 Pain Relevance 0.15
McDougall et al and Kirsch et al showed a decrease in urine output and in GFR with increasing intraabdominal pressure in animal models [24,25].
Negative_regulation (decrease) of GFR in urine
8) Confidence 0.18 Published 2010 Journal Korean Journal of Urology Section Body Doc Link PMC2858855 Disease Relevance 0.35 Pain Relevance 0
The GFR was significantly reduced 24, 48 and 72 h after the drug administration.
Negative_regulation (reduced) of GFR
9) Confidence 0.06 Published 2006 Journal Clin. Chim. Acta Section Body Doc Link 16806140 Disease Relevance 0.11 Pain Relevance 0
In vivo indomethacin potentiates the actions of ANG II on the kidney, particularly the reduction of RBF and GFR.
Negative_regulation (reduction) of GFR in kidney
10) Confidence 0.06 Published 1984 Journal Arch. Toxicol. Suppl. Section Abstract Doc Link 6595999 Disease Relevance 0.36 Pain Relevance 0.15
In this way, sodium balance can be maintained despite a diminishing GFR when intake of salt and water is unaltered in CRF.
Negative_regulation (diminishing) of GFR associated with natriuresis and chronic renal failure
11) Confidence 0.04 Published 2005 Journal Journal of Korean Medical Science Section Body Doc Link PMC2808601 Disease Relevance 0.84 Pain Relevance 0
Nocturia is associated with a loss of the diurnal variation in GFR in some cases [8], but nocturia is a common feature of many other lower urinary disorders, such as overactive bladder (OAB), partial bladder outlet obstruction (PBOO), interstitial cystitis (IC), and is correlated with advanced age [5], [14]–[16].
Negative_regulation (loss) of GFR in bladder associated with overactive bladder and interstitial cystitis
12) Confidence 0.04 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2924395 Disease Relevance 1.04 Pain Relevance 0.13
Finally, evidence in both animals and humans has been accrued to suggest that increased endothelin production may mediate the tubulointerstitial injury and decline in GFR noted with the metabolic acidosis of CKD [82, 86].


Negative_regulation (decline) of GFR associated with chronic renal failure, injury and acid base imbalance
13) Confidence 0.03 Published 2010 Journal Pediatr Nephrol Section Body Doc Link PMC2991191 Disease Relevance 1.46 Pain Relevance 0.04
Moreover, the bicarbonate group was less likely to experience a rapid decline in GFR or develop end-stage renal disease.
Negative_regulation (decline) of GFR associated with renal disease
14) Confidence 0.03 Published 2010 Journal Pediatr Nephrol Section Body Doc Link PMC2991191 Disease Relevance 1.29 Pain Relevance 0
In the latter study, the rate of decline in GFR in those given bicarbonate was less than half that in the control group.
Negative_regulation (decline) of GFR
15) Confidence 0.02 Published 2010 Journal Pediatr Nephrol Section Body Doc Link PMC2991191 Disease Relevance 1.40 Pain Relevance 0.05
The administration of sodium bicarbonate [75] or sodium citrate [76] to rats with 5/6 nephrectomy attenuated the degree of tubulointerstitial disease and decline in GFR when compared to controls receiving NaCl.
Negative_regulation (decline) of GFR associated with disease
16) Confidence 0.02 Published 2010 Journal Pediatr Nephrol Section Body Doc Link PMC2991191 Disease Relevance 1.22 Pain Relevance 0.08

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