INT44979

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Context Info
Confidence 0.59
First Reported 1984
Last Reported 2010
Negated 0
Speculated 0
Reported most in Abstract
Documents 11
Total Number 11
Disease Relevance 5.61
Pain Relevance 2.41

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (Pnp) extracellular region (Pnp) transferase activity, transferring glycosyl groups (Pnp)
cytoskeleton (Pnp) nucleus (Pnp) intracellular (Pnp)
Anatomy Link Frequency
body 2
B cells 1
spleen 1
primary sensory neurons 1
Pnp (Mus musculus)
Pain Link Frequency Relevance Heat
Neuropathic pain 16 100.00 Very High Very High Very High
endometriosis 13 100.00 Very High Very High Very High
dorsal root ganglion 8 99.32 Very High Very High Very High
ectopic activity 2 98.16 Very High Very High Very High
anesthesia 12 97.48 Very High Very High Very High
Bile 13 86.00 High High
abdominal pain 1 85.28 High High
Pain 3 25.00 Low Low
pain pelvic 1 25.00 Low Low
agonist 10 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Neuropathic Pain 16 100.00 Very High Very High Very High
Endometriosis (extended) 13 100.00 Very High Very High Very High
Bullous Skin Disease 8 100.00 Very High Very High Very High
Lymphatic System Cancer 1 99.90 Very High Very High Very High
Body Weight 14 99.74 Very High Very High Very High
Ganglion Cysts 8 99.32 Very High Very High Very High
Weight Loss 12 99.24 Very High Very High Very High
Disease 23 98.92 Very High Very High Very High
Acute Abdomen 2 98.92 Very High Very High Very High
Nervous System Injury 8 95.60 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Pathology of the spleen showed low-grade B-cell lymphoma had induced PNP.
Positive_regulation (induced) of PNP in spleen associated with lymphatic system cancer and bullous skin disease
1) Confidence 0.59 Published 2003 Journal J. Formos. Med. Assoc. Section Abstract Doc Link 14517589 Disease Relevance 1.26 Pain Relevance 0.10
Spontaneous ectopic activity of axotomized and non-axotomized primary sensory neurons, the bodies of which are located in the dorsal root ganglion (DRG), seems to be a key mechanism of PNP induction.
Positive_regulation (induction) of PNP in primary sensory neurons associated with ganglion cysts, dorsal root ganglion, neuropathic pain and ectopic activity
2) Confidence 0.59 Published 2009 Journal Ann. Anat. Section Abstract Doc Link 19403284 Disease Relevance 1.21 Pain Relevance 0.74
In this review, we draw attention to current knowledge on basic cellular and molecular events in various experimental models used to induce the PNP symptoms.
Positive_regulation (induce) of PNP associated with neuropathic pain
3) Confidence 0.45 Published 2009 Journal Ann. Anat. Section Abstract Doc Link 19403284 Disease Relevance 1.04 Pain Relevance 0.65
At the end of the 120-min perfusion period, PNP could be accounted for entirely as PNP-sulfate (PNP-S) and PNP-glucuronide (PNP-G).
Positive_regulation (accounted) of PNP-sulfate
4) Confidence 0.25 Published 1996 Journal Drug Metab. Dispos. Section Abstract Doc Link 8971145 Disease Relevance 0 Pain Relevance 0.18
At the end of the 120-min perfusion period, PNP could be accounted for entirely as PNP-sulfate (PNP-S) and PNP-glucuronide (PNP-G).
Positive_regulation (accounted) of PNP-glucuronide
5) Confidence 0.25 Published 1996 Journal Drug Metab. Dispos. Section Abstract Doc Link 8971145 Disease Relevance 0 Pain Relevance 0.19
At the end of the 120-min perfusion period, PNP could be accounted for entirely as PNP-sulfate (PNP-S) and PNP-glucuronide (PNP-G).
Positive_regulation (accounted) of PNP
6) Confidence 0.22 Published 1996 Journal Drug Metab. Dispos. Section Abstract Doc Link 8971145 Disease Relevance 0 Pain Relevance 0.18
The PNP was substantially higher in patients with confirmed SAA than in others and is potentially a very sensitive and very specific test of SAA.
Positive_regulation (higher) of PNP
7) Confidence 0.08 Published 1984 Journal Aust N Z J Surg Section Abstract Doc Link 6596077 Disease Relevance 0.26 Pain Relevance 0.09
As expected, the HA alone group showed the least amount of body weight loss, while groups HA+NP and HA+NP+M2 showed similar weight loss patterns (Figure 3B).
Positive_regulation (groups) of HA+NP in body associated with weight loss and body weight
8) Confidence 0.05 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2843722 Disease Relevance 0.42 Pain Relevance 0
As expected, the HA alone group showed the least amount of body weight loss, while groups HA+NP and HA+NP+M2 showed similar weight loss patterns (Figure 3B).
Positive_regulation (groups) of HA+NP in body associated with weight loss and body weight
9) Confidence 0.05 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2843722 Disease Relevance 0.43 Pain Relevance 0
Our findings indicated that FO B cells contributed significantly to the poly(I:C)-induced NP-Ficoll response, although the capacity of lymph node B cells to contribute to the TI-2 antibody response has been considered minimal (Ron and Sprent, 1985; Goud et al., 1988; Liu et al., 1988).
Positive_regulation (induced) of NP-Ficoll in B cells
10) Confidence 0.03 Published 2010 Journal The Journal of Experimental Medicine Section Body Doc Link PMC2901065 Disease Relevance 0.14 Pain Relevance 0
Group 1 target genes are up-regulated during the normal window of implantation but significantly decreased in women with endometriosis: IL-15, proline-rich protein, B61, Dickkopf-1, glycodelin, N-acetylglucosamine-6-O-sulfotransferase, G0S2 protein, and purine nucleoside phosphorylase.
Positive_regulation (up-regulated) of purine nucleoside phosphorylase associated with endometriosis
11) Confidence 0.01 Published 2003 Journal Endocrinology Section Abstract Doc Link 12810542 Disease Relevance 0.86 Pain Relevance 0.29

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