INT4498

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Context Info
Confidence 0.65
First Reported 1975
Last Reported 2010
Negated 3
Speculated 1
Reported most in Body
Documents 83
Total Number 84
Disease Relevance 57.40
Pain Relevance 10.80

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

peptidase activity (F2) extracellular space (F2) extracellular region (F2)
plasma membrane (F2)
Anatomy Link Frequency
platelet 10
plasma 9
blood 8
liver 3
monocyte 3
F2 (Homo sapiens)
F2 - G20210A (3)
Pain Link Frequency Relevance Heat
spastic colon 58 99.52 Very High Very High Very High
depression 16 99.42 Very High Very High Very High
Restless leg syndrome 301 99.08 Very High Very High Very High
Inflammation 481 98.88 Very High Very High Very High
cytokine 248 98.70 Very High Very High Very High
alcohol 17 98.48 Very High Very High Very High
cva 596 98.44 Very High Very High Very High
abdominal pain 33 97.76 Very High Very High Very High
anesthesia 31 97.16 Very High Very High Very High
carbamazepine 58 93.84 High High
Disease Link Frequency Relevance Heat
Pressure And Volume Under Development 101 100.00 Very High Very High Very High
Thrombocytopenia 99 100.00 Very High Very High Very High
Encephalopathy 41 100.00 Very High Very High Very High
Systemic Lupus Erythematosus 18 100.00 Very High Very High Very High
Leukocytosis 2 100.00 Very High Very High Very High
Myocardial Infarction 363 99.84 Very High Very High Very High
Injury 592 99.82 Very High Very High Very High
Hyperglycemia 227 99.76 Very High Very High Very High
Thrombosis Related Under Development 362 99.62 Very High Very High Very High
Irritable Bowel Syndrome /

Irritable Bowel Syndrome Super

51 99.52 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Mesenteric venous thrombosis in a patient with prothrombin 20210A mutation and antithrombin III deficiency: challenges to conventional anticoagulation--a case report.
Gene_expression (mutation) of prothrombin associated with thrombosis related under development
1) Confidence 0.65 Published 2003 Journal Vasc Endovascular Surg Section Title Doc Link 12894373 Disease Relevance 0.47 Pain Relevance 0.18
We used the following definitions: cardiac failure was defined as requiring use of inotropic agents; respiratory failure was defined as the need for assisted ventilatiory support; ARDS was defined as clinical deterioration with severe arterial hypoxaemia and diffuse bilateral infiltrates on chest radiograph; disseminated intravenous coagulation (DIC) was defined as elevated prothrombin time (PT) with elevated activated partial thromboplastin time (APTT), and decreased fibrinogen (FIB) level with thrombocytopenia; liver function impairment was defined as aminotransferase (ALT or AST) levels ?
Gene_expression (time) of prothrombin in chest associated with respiratory failure, thrombocytopenia, disseminated intravascular coagulation, adult respiratory distress syndrome and myocardial infarction
2) Confidence 0.65 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2515635 Disease Relevance 0.56 Pain Relevance 0.07
The following data were collected from the Institutional Database or direct analysis of the perfusion files: demographics: age (months), weight (kg), gender; type of surgical operation with Aristotle complexity score [16]; preoperative laboratory data: hematocrit (percentage), platelet count (cells/microliter), prothrombin time (seconds), activated partial thromboplastin time (seconds), antithrombin (percentage), serum creatinine value (milligrams per deciliter); CPB data: CPB duration (minutes), lowest temperature on CPB (degrees Centigrade), use of blood prime, ScVO2 values (percentage), and lactate values (mmol/L).
Gene_expression (time) of prothrombin in blood
3) Confidence 0.65 Published 2010 Journal Crit Care Section Body Doc Link PMC2945132 Disease Relevance 0 Pain Relevance 0
This condition develops as the result of the formation of antibodies to the heparin-platelet factor 4 complex, which causes secondary activation of platelets, coagulation, and ultimately increased thrombin production.33
Gene_expression (production.33) of thrombin in platelets
4) Confidence 0.64 Published 2010 Journal Vascular Health and Risk Management Section Body Doc Link PMC2879296 Disease Relevance 1.06 Pain Relevance 0.04
Augmented local thrombin production in myocardial infarction patients with glucose >7.0 mmol/l was accompanied by increased platelet activation, reflected by elevated sCD40L levels in venous plasma and bleeding time blood.
Gene_expression (production) of thrombin in blood associated with hemorrhage and myocardial infarction
5) Confidence 0.63 Published 2008 Journal Diabetes Care Section Body Doc Link PMC2494657 Disease Relevance 0.99 Pain Relevance 0
Serum levels of aminotransferases, prothrombin time, total bilirubin, alphafetoprotein and carcinoembryonic antigen were within normal limits.
Gene_expression (levels) of prothrombin
6) Confidence 0.60 Published 2003 Journal Eur J Gastroenterol Hepatol Section Abstract Doc Link 12610331 Disease Relevance 1.48 Pain Relevance 0.18
Data extracted from the patients' records included individual and obstetric characteristics (maternal age, parity, mode and term of delivery, cause of PPH), as well as those relevant to critical care, haemostasis and coagulation (shock, disseminated intravascular coagulation, mean haemoglobin level, mean platelet count, mean prothrombin time, mean partial thromboplastin time expressed as ratio to control values, mean number units of whole blood, fresh frozen plasma and platelets transfused).


Gene_expression (expressed) of prothrombin in plasma associated with shock, cva and thrombosis
7) Confidence 0.58 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2583949 Disease Relevance 0.59 Pain Relevance 0.12
[Occlusion of the renal artery by intra-arterial injection of thrombin in a case of inoperable renal tumour (author's transl)].
Gene_expression (injection) of thrombin in renal artery associated with renal cancer
8) Confidence 0.57 Published 1975 Journal Dtsch. Med. Wochenschr. Section Title Doc Link 1183357 Disease Relevance 0.38 Pain Relevance 0.09
Portal, splenic and mesenteric vein thrombosis in a patient double heterozygous for factor V Leiden and prothrombin G20210A mutation.
Gene_expression (mutation) of prothrombin G20210A (G20210A) in mesenteric vein associated with cv general 4 under development
9) Confidence 0.55 Published 2009 Journal Blood Coagul. Fibrinolysis Section Title Doc Link 19734780 Disease Relevance 0.80 Pain Relevance 0.14
Thrombophilia workup revealed double heterozygosity for factor V Leiden and prothrombin G20210A mutation.
Gene_expression (mutation) of prothrombin G20210A (G20210A) associated with thrombophilia
10) Confidence 0.55 Published 2009 Journal Blood Coagul. Fibrinolysis Section Abstract Doc Link 19734780 Disease Relevance 0.75 Pain Relevance 0.12
Using commercially available enzyme-linked immunosorbent assays, we determined the following in plasma: interleukin-6 (IL-6) (R&D Systems, Abingdon, U.K.); thrombin-antithrombin complexes (TATs) and prothrombin 1.2 fragments (F1.2), markers of thrombin formation (Enzygnost, Dade Behring); and soluble CD40 ligand (sCD40L), a marker of platelet activation (R&D Systems).
Gene_expression (complexes) of prothrombin in plasma
11) Confidence 0.54 Published 2008 Journal Diabetes Care Section Body Doc Link PMC2494657 Disease Relevance 0.08 Pain Relevance 0.03
The aim of the study was to evaluate potential prothrombotic alterations in acute myocardial infarction patients in relation to hyperglycemia, including thrombin formation, platelet activation, and fibrin network structure/function.
Gene_expression (formation) of thrombin in platelet associated with hyperglycemia and myocardial infarction
12) Confidence 0.54 Published 2008 Journal Diabetes Care Section Body Doc Link PMC2494657 Disease Relevance 1.60 Pain Relevance 0.11
Using commercially available enzyme-linked immunosorbent assays, we determined the following in plasma: interleukin-6 (IL-6) (R&D Systems, Abingdon, U.K.); thrombin-antithrombin complexes (TATs) and prothrombin 1.2 fragments (F1.2), markers of thrombin formation (Enzygnost, Dade Behring); and soluble CD40 ligand (sCD40L), a marker of platelet activation (R&D Systems).
Gene_expression (complexes) of thrombin in plasma
13) Confidence 0.54 Published 2008 Journal Diabetes Care Section Body Doc Link PMC2494657 Disease Relevance 0.13 Pain Relevance 0.03
It is well known that unfractionated heparin and low molecular weight heparins inhibit extrinsic thrombin generation.
Gene_expression (generation) of thrombin
14) Confidence 0.52 Published 1999 Journal Haemostasis Section Abstract Doc Link 10844403 Disease Relevance 0 Pain Relevance 0
Our results show that unfractionated and low molecular weight heparins potently inhibit monocytic tissue factor induced thrombin generation.
Gene_expression (generation) of thrombin
15) Confidence 0.52 Published 1999 Journal Haemostasis Section Abstract Doc Link 10844403 Disease Relevance 0 Pain Relevance 0.08
We adapted the technique of thrombin generation on an automatic analyzer and used human monocyte tissue factor to trigger thrombin generation.
Gene_expression (generation) of thrombin in monocyte
16) Confidence 0.52 Published 1999 Journal Haemostasis Section Abstract Doc Link 10844403 Disease Relevance 0 Pain Relevance 0.07
Comparative inhibition of LPS-activated human monocyte-induced thrombin generation by unfractionated heparin and low molecular weight heparins.
Gene_expression (generation) of thrombin in monocyte
17) Confidence 0.52 Published 1999 Journal Haemostasis Section Title Doc Link 10844403 Disease Relevance 0 Pain Relevance 0
We adapted the technique of thrombin generation on an automatic analyzer and used human monocyte tissue factor to trigger thrombin generation.
Gene_expression (generation) of thrombin in monocyte
18) Confidence 0.52 Published 1999 Journal Haemostasis Section Abstract Doc Link 10844403 Disease Relevance 0 Pain Relevance 0.06
It is often assumed that the conventional coagulation screens (INR and APTT) monitor coagulation; however, these tests monitor only the initiation phase of blood coagulation and represent only the first 4% of thrombin production [116].
Gene_expression (production) of thrombin in blood
19) Confidence 0.52 Published 2010 Journal Crit Care Section Body Doc Link PMC2887168 Disease Relevance 0.33 Pain Relevance 0
Hypercoagulability develops in septic patients, resulting in enhanced thrombin generation, thrombin activation, and fibrin formation.
Gene_expression (generation) of thrombin associated with thrombophilia
20) Confidence 0.51 Published 2006 Journal Crit Care Section Body Doc Link PMC1794466 Disease Relevance 0.73 Pain Relevance 0.09

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