INT45004

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Context Info
Confidence 0.37
First Reported 1983
Last Reported 2010
Negated 4
Speculated 1
Reported most in Body
Documents 28
Total Number 30
Disease Relevance 15.06
Pain Relevance 1.99

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cell proliferation (Cfb) peptidase activity (Cfb) extracellular space (Cfb)
extracellular region (Cfb)
Anatomy Link Frequency
neuronal 2
hepatocytes 1
smooth muscle 1
spinal cord 1
cleavage 1
Cfb (Mus musculus)
Pain Link Frequency Relevance Heat
tolerance 11 96.64 Very High Very High Very High
Inflammation 216 96.36 Very High Very High Very High
Spinal cord 2 95.92 Very High Very High Very High
Peripheral nervous system 1 95.84 Very High Very High Very High
spinal inflammation 8 92.72 High High
rheumatoid arthritis 383 92.20 High High
ischemia 94 86.80 High High
Central nervous system 13 81.52 Quite High
spondylitis 1 77.64 Quite High
cva 52 73.12 Quite High
Disease Link Frequency Relevance Heat
Brain Injury 157 99.80 Very High Very High Very High
Disease 300 99.72 Very High Very High Very High
Death 144 99.22 Very High Very High Very High
Flavivirus Infection 240 99.12 Very High Very High Very High
Cancer 97 97.76 Very High Very High Very High
Hyperplasia 4 97.48 Very High Very High Very High
Adhesions 12 97.08 Very High Very High Very High
Spinal Diseases 1 96.96 Very High Very High Very High
INFLAMMATION 246 96.36 Very High Very High Very High
Age-related Macular Degeneration 108 96.32 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
To further understand the functional role of galanin, a mouse overexpressing galanin under the platelet-derived growth factor-B was generated, and high levels of galanin expression were observed in several peripheral tissues and spinal cord.
Gene_expression (overexpressing) of factor-B in spinal cord associated with spinal cord
1) Confidence 0.37 Published 2005 Journal Neuroscience Section Abstract Doc Link 15893631 Disease Relevance 0.13 Pain Relevance 0.13
This alternative pathway activation was due to the decrease in CFH levels and increase in CFB levels in the RPE/choroid after laser treatment [94].
Gene_expression (levels) of CFB in choroid
2) Confidence 0.31 Published 2008 Journal Semin Immunopathol Section Body Doc Link PMC2315691 Disease Relevance 0.69 Pain Relevance 0
Biotinylated citrullinated fibrinogen (CFb) was produced as previously reported [43] and tested for specificity using pooled sera from three ACPA+ and three ACPA?
Gene_expression (produced) of CFb
3) Confidence 0.26 Published 2009 Journal PLoS Medicine Section Body Doc Link PMC2621263 Disease Relevance 0.09 Pain Relevance 0.05
Numerous positive cells were detected with CFb (Figure 4B) but not when using Fb as a negative control (Figure 4C) in ACPA+ patients.
Neg (not) Gene_expression (detected) of CFb
4) Confidence 0.22 Published 2009 Journal PLoS Medicine Section Body Doc Link PMC2621263 Disease Relevance 0.19 Pain Relevance 0.07
Biotinylated CFb and biotinylated Fb were then used to detect in situ production of ACPA in sections double stained for CD20 (Figure 4B and 4C).
Gene_expression (detect) of CFb
5) Confidence 0.22 Published 2009 Journal PLoS Medicine Section Body Doc Link PMC2621263 Disease Relevance 0.09 Pain Relevance 0.05
The lack of factor B leads to reduced neuronal cell death after head injury
Neg (lack) Gene_expression (lack) of factor B in neuronal associated with brain injury and death
6) Confidence 0.21 Published 2006 Journal BMC Neurosci Section Body Doc Link PMC1540436 Disease Relevance 1.46 Pain Relevance 0.16
We therefore used a newly available, highly specific and potent inhibitor of the alternative complement pathway, the mAb 1379 monoclonal anti-factor B antibody, in the identical head injury model.
Gene_expression (antibody) of factor B in head associated with brain injury
7) Confidence 0.19 Published 2007 Journal J Neuroinflammation Section Body Doc Link PMC1867808 Disease Relevance 1.37 Pain Relevance 0.24
Screening of serum samples from all fB-/- mice and wild-type littermates (fB+/+) used in the present study revealed that factor B was only detectable in serum of fB+/+ animals, but not in the fB-/- mice.
Gene_expression (detectable) of factor B
8) Confidence 0.19 Published 2006 Journal BMC Neurosci Section Body Doc Link PMC1540436 Disease Relevance 0.83 Pain Relevance 0.10
Here, we demonstrate for the first time an important role of the alternative complement pathway in contributing to posttraumatic neuronal cell death, based on a standardized TBI model in factor B gene-deficient mice.


Gene_expression (deficient) of factor B in neuronal associated with brain injury and death
9) Confidence 0.19 Published 2006 Journal BMC Neurosci Section Body Doc Link PMC1540436 Disease Relevance 0.93 Pain Relevance 0.12
The results indicated that IxAC proteins prevented C3b and factor B deposition in agarose-coated wells when added together with serum (not shown).
Gene_expression (deposition) of factor B
10) Confidence 0.08 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2151134 Disease Relevance 0 Pain Relevance 0
5000) or goat anti-human factor B serum (Quidel, dilution 1?
Gene_expression (serum) of factor B
11) Confidence 0.08 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2151134 Disease Relevance 0.06 Pain Relevance 0
200 mM), the amount of bound Bb dropped to values observed when reconstituting the C3 convertase without properdin (Figure 8A).
Neg (without) Gene_expression (reconstituting) of properdin
12) Confidence 0.08 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2151134 Disease Relevance 0 Pain Relevance 0
This is consistent with the finding that properdin is present in the serum as dimer, trimer and tetramer [55] forms.
Gene_expression (present) of properdin
13) Confidence 0.07 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2151134 Disease Relevance 0 Pain Relevance 0
Bound Bb and properdin were detected using specific antibodies.
Gene_expression (detected) of properdin
14) Confidence 0.07 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2151134 Disease Relevance 0 Pain Relevance 0
This must take into account properdin concentration (?
Gene_expression (concentration) of properdin
15) Confidence 0.07 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2151134 Disease Relevance 0.40 Pain Relevance 0.12
C5 convertase cleaves C5 into C5a and C5b.
Gene_expression (cleaves) of convertase
16) Confidence 0.07 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2151134 Disease Relevance 0.11 Pain Relevance 0.03
200 mM), the amount of bound Bb dropped to values observed when reconstituting the C3 convertase without properdin (Figure 8A).
Neg (without) Gene_expression (reconstituting) of convertase
17) Confidence 0.07 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2151134 Disease Relevance 0 Pain Relevance 0
The central convergence point of all three pathways is the formation of a C3 convertase on the surface of a particular cell.
Gene_expression (formation) of convertase
18) Confidence 0.04 Published 2008 Journal Biologics : Targets & Therapy Section Body Doc Link PMC2727911 Disease Relevance 0.51 Pain Relevance 0
CVF binds to mammalian FB in plasma and after cleavage of FB by FD, a stable, soluble C3 convertase is produced, the CVF-Bb complex (Cooper 1973).
Gene_expression (produced) of convertase in cleavage
19) Confidence 0.04 Published 2008 Journal Biologics : Targets & Therapy Section Body Doc Link PMC2727911 Disease Relevance 0 Pain Relevance 0
The function of the C3 convertase in all three pathways is to further cleave C3, producing C3a, one of the two major anaphylatoxins of the complement system, and C3b, a potent opsonin.
Gene_expression (function) of convertase
20) Confidence 0.04 Published 2008 Journal Biologics : Targets & Therapy Section Body Doc Link PMC2727911 Disease Relevance 0.05 Pain Relevance 0.03

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