INT45041

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Context Info
Confidence 0.66
First Reported 1984
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 18
Total Number 24
Disease Relevance 15.45
Pain Relevance 1.59

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular region (IGLL1)
Anatomy Link Frequency
B cells 6
spleen 4
lymphocytes 3
small intestine 2
monocyte 1
IGLL1 (Homo sapiens)
Pain Link Frequency Relevance Heat
rheumatoid arthritis 207 99.28 Very High Very High Very High
cytokine 105 98.68 Very High Very High Very High
Inflammation 125 97.44 Very High Very High Very High
headache 9 92.40 High High
Arthritis 13 84.24 Quite High
lidocaine 1 80.76 Quite High
metalloproteinase 2 80.60 Quite High
Opioid 1 79.60 Quite High
psoriasis 4 61.40 Quite High
cva 12 29.68 Quite Low
Disease Link Frequency Relevance Heat
Cancer 71 99.98 Very High Very High Very High
Influenza Virus Infection 232 99.80 Very High Very High Very High
Apoptosis 186 99.58 Very High Very High Very High
Rheumatoid Arthritis 207 99.28 Very High Very High Very High
Amnesia 27 99.12 Very High Very High Very High
Acquired Immune Deficiency Syndrome Or Hiv Infection 288 98.86 Very High Very High Very High
Chronic Lymphoid Leukemia 8 98.52 Very High Very High Very High
Syndrome 4 97.60 Very High Very High Very High
INFLAMMATION 122 97.44 Very High Very High Very High
Immunoblastic Large-cell Lymphoma 2 96.80 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
To illustrate the use of this protocol we present a monocyte titration experiment which demonstrated a plateau of optimal pokeweed mitogen-stimulated Ig production at 5-10% monocytes.
Gene_expression (production) of Ig in monocyte
1) Confidence 0.66 Published 1984 Journal J. Immunol. Methods Section Abstract Doc Link 6609998 Disease Relevance 0 Pain Relevance 0.08
A binding assay using recombinant IgLONs fused to human Fc showed that IgLONs are organized in the plane of the membrane as heterodimers, and we propose that IgLONs function predominantly as subunits of heterodimeric proteins (Diglons).
Gene_expression (organized) of IgLONs
2) Confidence 0.11 Published 2004 Journal J. Cell. Sci. Section Abstract Doc Link 15265982 Disease Relevance 0.43 Pain Relevance 0.08
The number of B cells producing Pneumo23-specific switched Ig was lower (but not significant) as compared with the influenza-specific B cells.
Gene_expression (producing) of Ig in B cells associated with influenza virus infection
3) Confidence 0.03 Published 2010 Journal Arthritis Res Ther Section Body Doc Link PMC2911904 Disease Relevance 0.52 Pain Relevance 0
Vaccine-specific production of Ig light chains after RTX treatment
Gene_expression (production) of Ig
4) Confidence 0.03 Published 2010 Journal Arthritis Res Ther Section Body Doc Link PMC2911904 Disease Relevance 0.52 Pain Relevance 0
was elevated only in controls (P = 0.001), but neither in post-RTX nor in pre-RTX groups, suggesting that RTX may disrupt the production of Ig-?.
Gene_expression (production) of Ig
5) Confidence 0.03 Published 2010 Journal Arthritis Res Ther Section Body Doc Link PMC2911904 Disease Relevance 0.52 Pain Relevance 0
and Ig-| production.
Gene_expression (production) of Ig associated with influenza virus infection
6) Confidence 0.03 Published 2010 Journal Arthritis Res Ther Section Body Doc Link PMC2911904 Disease Relevance 0.79 Pain Relevance 0.10
and Ig-| production.
Gene_expression (production) of Ig associated with influenza virus infection
7) Confidence 0.03 Published 2010 Journal Arthritis Res Ther Section Body Doc Link PMC2911904 Disease Relevance 0.78 Pain Relevance 0.10
These primary B cells express vaccine-specific Ig on the surface, detected in our study with ELISPOT.
Gene_expression (express) of Ig in B cells
8) Confidence 0.03 Published 2010 Journal Arthritis Res Ther Section Body Doc Link PMC2911904 Disease Relevance 0.34 Pain Relevance 0.10
These primary B cells express vaccine-specific Ig on the surface, detected in our study with ELISPOT.
Gene_expression (detected) of Ig in B cells
9) Confidence 0.03 Published 2010 Journal Arthritis Res Ther Section Body Doc Link PMC2911904 Disease Relevance 0.39 Pain Relevance 0.10
SIV non-specific Ig production was transiently increased before D14p.i., whereas SIV-specific Ig production was only detectable after D14p.i., coinciding with the presence of CD8+ T-cells and IgG-expressing plasma cells within germinal centres.
Gene_expression (production) of Ig in T-cells
10) Confidence 0.02 Published 2009 Journal PLoS ONE Section Abstract Doc Link PMC2695011 Disease Relevance 0.82 Pain Relevance 0.06
Consistent with unresponsiveness to early HAART, we suggest that T-independent signals, possibly triggered by direct contact with virions and relayed by inflammatory cytokines, are important in early B-cell dysfunction—a major feature of the SIV/HIV-specific B-cell response strongly favoring non-specific Ig production.
Gene_expression (production) of Ig in B-cell associated with inflammation, acquired immune deficiency syndrome or hiv infection and cytokine
11) Confidence 0.02 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2695011 Disease Relevance 0.61 Pain Relevance 0.19
Previous data obtained in SIV- or HIV-infected individuals suggest that apoptosis is induced by various virus-induced signals [41], [42], whereas Ig production is rather promoted by increased cytokine production [43], [44].
Gene_expression (production) of Ig associated with acquired immune deficiency syndrome or hiv infection, apoptosis and cytokine
12) Confidence 0.02 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2695011 Disease Relevance 0.58 Pain Relevance 0.13
HAART abrogated B-cell apoptosis, homing to the small intestine and SIV-specific Ig production but had minimal effect on early Ig production, increased B-cell proportions in spleen and loss of memory B-cells.
Gene_expression (production) of Ig in spleen associated with amnesia and apoptosis
13) Confidence 0.02 Published 2009 Journal PLoS ONE Section Abstract Doc Link PMC2695011 Disease Relevance 0.65 Pain Relevance 0.09
HAART abrogated B-cell apoptosis, homing to the small intestine and SIV-specific Ig production but had minimal effect on early Ig production, increased B-cell proportions in spleen and loss of memory B-cells.
Gene_expression (production) of Ig in spleen associated with amnesia and apoptosis
14) Confidence 0.02 Published 2009 Journal PLoS ONE Section Abstract Doc Link PMC2695011 Disease Relevance 0.66 Pain Relevance 0.09
Our data show that SIV induced a transient increase in B-cell apoptosis and SIV non-specific Ig production by D14p.i., a steady loss of memory B-cells in spleen and peripheral LN but promoted preferential B-cell trafficking to the small intestine and spleen.
Gene_expression (production) of Ig in small intestine associated with amnesia and apoptosis
15) Confidence 0.02 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2695011 Disease Relevance 0.77 Pain Relevance 0
Changes in B-cell functions in vitro (proliferation, apoptosis or immunoglogulins (Ig) production) as well as in tissue organization of areas populated by B-cells within lymphoid tissues (spleen, small intestine and mesenteric LN) were concomitantly examined in placebo- or HAART-treated animals.
Gene_expression (production) of Ig in small intestine associated with apoptosis
16) Confidence 0.02 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2695011 Disease Relevance 0.91 Pain Relevance 0
Finally, IL-4 downregulates the surface expression of CD5 on B cells and inhibits spontaneous Ig and IgM rheumatoid factor production in patients with RA [77].
Gene_expression (production) of Ig in B cells associated with rheumatoid arthritis
17) Confidence 0.02 Published 2005 Journal Arthritis Res Ther Section Body Doc Link PMC2833981 Disease Relevance 0.82 Pain Relevance 0.40
Changes in B-cell functions in vitro (proliferation, apoptosis or immunoglogulins (Ig) production) as well as in tissue organization of areas populated by B-cells within lymphoid tissues (spleen, small intestine and mesenteric LN) were concomitantly examined in placebo- or HAART-treated animals.
Gene_expression (production) of Ig in spleen associated with apoptosis
18) Confidence 0.01 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2695011 Disease Relevance 0.91 Pain Relevance 0
Our data show that SIV induced a transient increase in B-cell apoptosis and SIV non-specific Ig production by D14p.i., a steady loss of memory B-cells in spleen and peripheral LN but promoted preferential B-cell trafficking to the small intestine and spleen.
Gene_expression (production) of Ig in spleen associated with amnesia and apoptosis
19) Confidence 0.01 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2695011 Disease Relevance 0.77 Pain Relevance 0
In a study of cultured human lymphocytes, increased Ig production was observed in cells exposed to lower levels of TCs (T-2, DAS, DON, NIV), whereas decreased Ig production was reported at higher levels [77].
Gene_expression (production) of Ig in lymphocytes
20) Confidence 0.01 Published 2008 Journal International Journal of Molecular Sciences Section Body Doc Link PMC2635619 Disease Relevance 0.22 Pain Relevance 0

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