INT45064

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Context Info
Confidence 0.86
First Reported 1983
Last Reported 2003
Negated 0
Speculated 0
Reported most in Body
Documents 6
Total Number 6
Disease Relevance 0
Pain Relevance 1.80

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

signal transduction (TRIM13) endoplasmic reticulum (TRIM13) intracellular (TRIM13)
ligase activity (TRIM13) cytoplasm (TRIM13) signal transducer activity (TRIM13)
Anatomy Link Frequency
Caco-2 2
plasma 1
TRIM13 (Homo sapiens)
Pain Link Frequency Relevance Heat
Somatostatin 4 100.00 Very High Very High Very High
Enkephalin 16 99.96 Very High Very High Very High
opioid receptor 2 97.68 Very High Very High Very High
Neuropeptide 6 90.12 High High
Delta opioid receptors 2 88.88 High High
Potency 2 85.76 High High
agonist 1 58.64 Quite High
analgesia 1 55.68 Quite High
tail-flick 1 54.80 Quite High
Opioid 6 50.00 Quite Low

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Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The kinetics of degradation of the synthetic peptoids digestion by rat and human plasma enzymes were compared with that of [Leu5]-enkephalin.
Protein_catabolism (degradation) of Leu5 in plasma associated with enkephalin
1) Confidence 0.86 Published 2003 Journal J. Pept. Sci. Section Abstract Doc Link 14620129 Disease Relevance 0 Pain Relevance 0.41
The synthesis, bioactivity and enzyme stability of D-Ala2, EPhe4, Leu5-enkephalins.
Protein_catabolism (stability) of Leu5 associated with enkephalin
2) Confidence 0.64 Published 1983 Journal Biochem. Biophys. Res. Commun. Section Title Doc Link 6615520 Disease Relevance 0 Pain Relevance 0.29
Phosphoramidon and DL-thiorphan similarly inhibited the degradation of GRP-10 (mean of 35% inhibition), somatostatin-14 (57%) and the aminopeptidase-resistant analogue, [D-Ala2][Leu5]enkephalin (75%).
Protein_catabolism (degradation) of Leu5 associated with somatostatin and enkephalin
3) Confidence 0.63 Published 1993 Journal Exp. Physiol. Section Abstract Doc Link 8448012 Disease Relevance 0 Pain Relevance 1.10
Prodrug 1 was 1680 fold more able to permeate the Caco-2 cell monolayers than was [Leu5]-enkephalin, in part because of its increased enzymatic stability.
Protein_catabolism (stability) of Leu5 in Caco-2
4) Confidence 0.43 Published 1999 Journal Pharm. Res. Section Body Doc Link 9950273 Disease Relevance 0 Pain Relevance 0
Prodrug 1 was 665-fold more able to permeate the Caco-2 cell monolayers than was [Leu5]-enkephalin, in part because of its increased enzymatic stability.
Protein_catabolism (stability) of Leu5 in Caco-2
5) Confidence 0.40 Published 1999 Journal Pharm. Res. Section Body Doc Link 9950272 Disease Relevance 0 Pain Relevance 0
RESULTS: Cyclic prodrugs 1 and 2 degraded slowly but stoichiometrically to [Leu5]-enkephalin and DADLE, respectively, in HBSS, pH = 7.4.
Protein_catabolism (degraded) of Leu5
6) Confidence 0.33 Published 1999 Journal Pharm. Res. Section Body Doc Link 9950274 Disease Relevance 0 Pain Relevance 0

General Comments

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