INT45067

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Context Info
Confidence 0.34
First Reported 1983
Last Reported 2010
Negated 0
Speculated 1
Reported most in Abstract
Documents 4
Total Number 5
Disease Relevance 1.51
Pain Relevance 1.15

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

mitochondrion (Ado) oxidoreductase activity (Ado)
Anatomy Link Frequency
embryos 1
nervous system 1
Ado (Mus musculus)
Pain Link Frequency Relevance Heat
adenocard 51 100.00 Very High Very High Very High
induced neuropathy 2 99.24 Very High Very High Very High
Analgesic 6 95.96 Very High Very High Very High
Catecholamine 1 64.00 Quite High
agonist 1 58.80 Quite High
Morphine 6 44.00 Quite Low
Pain 2 36.56 Quite Low
Bioavailability 4 31.64 Quite Low
Potency 13 31.36 Quite Low
antagonist 12 25.00 Low Low
Disease Link Frequency Relevance Heat
Diabetes Mellitus 63 99.68 Very High Very High Very High
Neuropathic Pain 2 99.24 Very High Very High Very High
Nociception 8 97.48 Very High Very High Very High
Increased Venous Pressure Under Development 11 90.00 High High
Death 1 66.48 Quite High
Paralysis 1 65.80 Quite High
Ataxia 1 65.24 Quite High
Targeted Disruption 2 51.44 Quite High
Pain 2 36.56 Quite Low
Cancer 15 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Inhibition of the ADO-metabolizing enzyme, ADO kinase (AK), provides a means of locally enhancing extracellular ADO concentrations.
Negative_regulation (Inhibition) of ADO associated with adenocard
1) Confidence 0.34 Published 1999 Journal Pharmacol. Biochem. Behav. Section Abstract Doc Link 10340527 Disease Relevance 0.25 Pain Relevance 0.40
In the present study, the AK inhibitors 5'-amino,5'-deoxy-ADO (NH2dADO), 5-iodotubercidin (5-IT), and 5'-deoxy,5-iodotubercidin (5'd-5IT) were examined for their analgesic efficacy in the hot-plate model of acute somatic nociception.
Spec (examined) Negative_regulation (inhibitors) of ADO associated with nociception, adenocard and analgesic
2) Confidence 0.34 Published 1999 Journal Pharmacol. Biochem. Behav. Section Abstract Doc Link 10340527 Disease Relevance 0.26 Pain Relevance 0.42
Until the present, most single cell WGA studies have been motivated by applications in pre-implantation genetic diagnosis, and since ADO represents the greatest challenge in this field (potentially resulting in misdiagnosis of embryos), much emphasis was put on reducing ADO rates to the minimum.
Negative_regulation (reducing) of ADO in embryos
3) Confidence 0.12 Published 2008 Journal BMC Biotechnol Section Body Doc Link PMC2266725 Disease Relevance 0 Pain Relevance 0
These results suggest that the N2O-induced neuropathy in the fruit bat is not related to a depletion of Ado Met in the nervous system.
Negative_regulation (depletion) of Ado in nervous system associated with induced neuropathy and neuropathic pain
4) Confidence 0.12 Published 1983 Journal Br. J. Nutr. Section Abstract Doc Link 6615764 Disease Relevance 0.37 Pain Relevance 0.17
Despite the reduced vasodilatatory capacity of ATP, UTP, and ADO in the diabetic subjects, the response to exercise was diminished by ?
Negative_regulation (reduced) of ADO associated with adenocard and diabetes mellitus
5) Confidence 0.03 Published 2010 Journal Diabetes Section Body Doc Link PMC2797920 Disease Relevance 0.64 Pain Relevance 0.16

General Comments

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