INT45079

Context Info Confidence 0.44 First Reported 1983 Last Reported 2010 Negated 2 Speculated 0 Reported most in Body Documents 21 Total Number 21 Disease Relevance 10.07 Pain Relevance 1.00

immune system process (Ahr) cell morphogenesis (Ahr) DNA binding (Ahr) response to stress (Ahr) cytoplasm (Ahr) signal transducer activity (Ahr)

Anatomy Link Frequency nucleus 3 B-cell 1 band 1 lung 1 eosinophils 1 Ahr (Mus musculus)

Pain Link Frequency Relevance Heat tetrodotoxin 4 99.22 Inflammation 178 91.24 Action potential 1 88.92 nMDA receptor 2 87.00 fortral 2 82.88 agonist 41 80.32 Potency 4 76.92 cytokine 69 68.52 chemokine 11 67.96 Neurotransmitter 35 32.96

Disease Link Frequency Relevance Heat Asthma 427 100.00 Occupational Lung Diseases 43 100.00 Metabolic Syndrome 24 100.00 Bronchitis 9 99.90 Shock 1 99.56 Prostate Cancer 112 99.10 Infection 35 97.96 Toxicity 21 97.24 Disease 81 94.68 Hypoxia 2 94.52

Sentences Mentioned In

Key:

Protein

Mutation

Event

Anatomy

Negation

Speculation

Pain term

Disease term

The increased protection is not related to interaction of these drugs with the Ah receptor.

Ah receptor Binding (interaction) of

1) Confidence 0.44 Published 1983 Journal Dev Pharmacol Ther Section Abstract Doc Link 6617407 Disease Relevance 0 Pain Relevance 0.15

Since the primers for AhR amplify both rat and mouse AhR, these results indicate that N2a-R?

AhR Binding (primers) of

2) Confidence 0.36 Published 2006 Journal Environ Health Section Body Doc Link PMC1570454 Disease Relevance 0.11 Pain Relevance 0

Although immunoreactivity for AhR was not detected in the N2a-Vc and Neuro2a cells, the protein band corresponding to the molecular weight of AhR was clearly detected in N2a-R?.

AhR Binding (immunoreactivity) of in band

3) Confidence 0.36 Published 2006 Journal Environ Health Section Body Doc Link PMC1570454 Disease Relevance 0 Pain Relevance 0

The AhR primers were designed for rat AhR, but also specifically recognize and amplify mouse AhR under identical PCR conditions (Fig 2A).

AhR Binding (recognize) of

4) Confidence 0.36 Published 2006 Journal Environ Health Section Body Doc Link PMC1570454 Disease Relevance 0.20 Pain Relevance 0

The AhR–Arnt heterodimers then bind to their recognition sequence, the dioxin-responsive element (DRE) (Mimura and Fujii-Kuriyama 2003).

AhR Binding (bind) of

5) Confidence 0.35 Published 2008 Journal Environ Health Perspect Section Body Doc Link PMC2265056 Disease Relevance 0.48 Pain Relevance 0.03

Once these xenobiotics are recognized by AhR, the AhR–ligand complexes translocate into the nucleus and form heterodimers with its partner coactivator, AhR nuclear translocator (Arnt).

AhR Binding (recognized) of in nucleus

6) Confidence 0.35 Published 2008 Journal Environ Health Perspect Section Body Doc Link PMC2265056 Disease Relevance 0.28 Pain Relevance 0

The AhR is activated by binding to ligands, including dioxins, translocates from the cytoplasm to the nucleus and then binds to the consensus sequence known as XRE (xenobiotic responsive element) [7].

AhR Binding (binds) of in nucleus

7) Confidence 0.34 Published 2006 Journal Environ Health Section Body Doc Link PMC1570454 Disease Relevance 0.08 Pain Relevance 0

The AhR is activated by binding to ligands, including dioxins, translocates from the cytoplasm to the nucleus and then binds to the consensus sequence known as XRE (xenobiotic responsive element) [7].

AhR Binding (binding) of in nucleus

8) Confidence 0.34 Published 2006 Journal Environ Health Section Body Doc Link PMC1570454 Disease Relevance 0.08 Pain Relevance 0

AhR regulates the transcription of diverse genes through binding to the xenobiotic-responsive element (XRE).

AhR Binding (binding) of

9) Confidence 0.34 Published 2006 Journal Environ Health Section Abstract Doc Link PMC1570454 Disease Relevance 0.25 Pain Relevance 0

To target the AhR we used the following shRNA sequences: 1. 5?

AhR Binding (target) of

10) Confidence 0.33 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2816705 Disease Relevance 0.23 Pain Relevance 0

Recent studies revealed a connection between the AhR pathway and prostate cancer both in vitro and in vivo, showing that the AhR interacts and inhibits the AR.

AhR Binding (interacts) of associated with prostate cancer

11) Confidence 0.32 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2816705 Disease Relevance 0.43 Pain Relevance 0.03

The AhR primers were designed for rat AhR, but also specifically recognize and amplify mouse AhR under identical PCR conditions (Fig 2A).

AhR Binding (amplify) of

12) Confidence 0.31 Published 2006 Journal Environ Health Section Body Doc Link PMC1570454 Disease Relevance 0.19 Pain Relevance 0

This raises the question: Why is EB not associated with AHR if eosinophils contribute to AHR?

AHR Binding (associated) of in eosinophils associated with occupational lung diseases and bronchitis

13) Confidence 0.27 Published 2008 Journal Allergy Asthma Clin Immunol Section Body Doc Link PMC2868889 Disease Relevance 2.36 Pain Relevance 0.07

The binding of 3-MC to the aryl hydrocarbon receptor (AHR) forms a AHR/3-MC complex, which upregulates CYP1A1, CYP1A2, and CYP1B1 expression by binding, together with the AHR nuclear translocator (ARNT), to the XREs of these genes [30].

aryl hydrocarbon receptor Binding (binding) of

14) Confidence 0.26 Published 2009 Journal PPAR Research Section Body Doc Link PMC2768028 Disease Relevance 0.13 Pain Relevance 0.04

The binding of 3-MC to the aryl hydrocarbon receptor (AHR) forms a AHR/3-MC complex, which upregulates CYP1A1, CYP1A2, and CYP1B1 expression by binding, together with the AHR nuclear translocator (ARNT), to the XREs of these genes [30].

AHR Binding (binding) of

15) Confidence 0.26 Published 2009 Journal PPAR Research Section Body Doc Link PMC2768028 Disease Relevance 0.13 Pain Relevance 0.04

The impairment of COX-2 expression and activity caused by the antisense oligonucleotide was associated with a worsening of AHR.

AHR Binding (associated) of associated with asthma

16) Confidence 0.25 Published 2008 Journal Respir Res Section Body Doc Link PMC2600823 Disease Relevance 0.39 Pain Relevance 0

Furthermore, TTX and MK801 differentially affected the association of AhR and its transcriptional co-activator cAMP-responsive-element binding protein with the cytochrome P450 1A1 (cyp1A1) gene enhancer.

AhR Binding (association) of associated with tetrodotoxin

17) Confidence 0.21 Published 2008 Journal J. Neurochem. Section Abstract Doc Link 17973980 Disease Relevance 0.15 Pain Relevance 0.54

In that same study, an increased expression and production of IL-9 in the lung was associated with AHR in DBA/J2 mice.

AHR Binding (associated) of in lung

18) Confidence 0.15 Published 2010 Journal Journal of Allergy Section Body Doc Link PMC2957587 Disease Relevance 0.35 Pain Relevance 0.11

No association was also observed between metabolic syndrome and AHR or asthma and AHR in all children or in boys and girls separately.

AHR Neg (No) Binding (association) of associated with asthma and metabolic syndrome

19) Confidence 0.07 Published 2007 Journal Allergy Asthma Clin Immunol Section Body Doc Link PMC2875553 Disease Relevance 1.89 Pain Relevance 0

Conclusion: There was no association between metabolic syndrome at age 10 to 11 and prevalent asthma or AHR, but we are in the process of recruiting children for the third wave of the SAGE study and soon will have results on the association between metabolic syndrome and incident asthma at age 12 years.

AHR Neg (no) Binding (association) of associated with asthma and metabolic syndrome

20) Confidence 0.07 Published 2007 Journal Allergy Asthma Clin Immunol Section Body Doc Link PMC2875553 Disease Relevance 1.80 Pain Relevance 0

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