INT4509

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Context Info
Confidence 0.76
First Reported 1975
Last Reported 2011
Negated 26
Speculated 12
Reported most in Body
Documents 426
Total Number 439
Disease Relevance 293.69
Pain Relevance 56.64

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

Anatomy Link Frequency
B cells 14
cerebrospinal fluid 9
CII 9
T-cell 9
blood 8
IGG (Mus musculus)
Pain Link Frequency Relevance Heat
Inflammation 2499 100.00 Very High Very High Very High
cytokine 1859 100.00 Very High Very High Very High
Spinal cord 924 100.00 Very High Very High Very High
Nicotine 227 100.00 Very High Very High Very High
intrathecal 55 99.98 Very High Very High Very High
rheumatoid arthritis 2450 99.84 Very High Very High Very High
spinal inflammation 58 99.66 Very High Very High Very High
diclofenac 180 99.64 Very High Very High Very High
Arthritis 1698 99.62 Very High Very High Very High
Pain 284 99.56 Very High Very High Very High
Disease Link Frequency Relevance Heat
Infection 3625 100.00 Very High Very High Very High
Neuromyelitis Optica 2732 100.00 Very High Very High Very High
INFLAMMATION 2719 100.00 Very High Very High Very High
Influenza Virus Infection 1222 100.00 Very High Very High Very High
Bullous Skin Disease 1082 100.00 Very High Very High Very High
Malaria 652 100.00 Very High Very High Very High
Motor Neuron Diseases 612 100.00 Very High Very High Very High
Viral Meningitis 574 100.00 Very High Very High Very High
Togavirus Infection 498 100.00 Very High Very High Very High
Cytomegalovirus Infection 435 100.00 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Intrathecal synthesis of virus-specific oligoclonal IgG, and of free kappa and free lambda oligoclonal bands in acute monosymptomatic optic neuritis.
Gene_expression (synthesis) of IgG in optic associated with optic neuritis, neuritis and intrathecal
1) Confidence 0.76 Published 1998 Journal Mult. Scler. Section Title Doc Link 9532588 Disease Relevance 0.58 Pain Relevance 0.33
Local synthesis of specific IgG in the cerebrospinal fluid of patients with neurosarcoidosis detected by antigen immunoblotting using Kveim material.
Gene_expression (synthesis) of IgG in cerebrospinal fluid
2) Confidence 0.76 Published 1990 Journal J. Neurol. Sci. Section Title Doc Link 2086723 Disease Relevance 0.46 Pain Relevance 0.12
The technique of antigen immunoblotting for detection of specific immunoglobulin G (IgG), using Kveim material as antigen, was applied to paired sera and cerebrospinal fluid from 11 patients with definite neurosarcoidosis, 9 patients with definite sarcoidosis and suspected neurosarcoidosis, 22 patients with possible neurosarcoidosis and 16 patients with other neurological disorders, including multiple sclerosis and optic neuritis.
Gene_expression (detection) of IgG in optic associated with multiple sclerosis, neurological disease, sarcoidosis, optic neuritis and neuritis
3) Confidence 0.76 Published 1990 Journal J. Neurol. Sci. Section Abstract Doc Link 2086723 Disease Relevance 0.42 Pain Relevance 0.13
Those patients whose cerebrospinal fluid showed local synthesis of oligoclonal total IgG were more likely to have local synthesis of Kveim-specific IgG, but not necessarily in an oligoclonal fashion.
Gene_expression (synthesis) of IgG in cerebrospinal fluid
4) Confidence 0.76 Published 1990 Journal J. Neurol. Sci. Section Abstract Doc Link 2086723 Disease Relevance 0.42 Pain Relevance 0.10
Six of the 11 (55%) patients with neurosarcoidosis, none of the 9 patients with definite sarcoidosis and suspected neurosarcoidosis, 5 of the 22 (23%) with possible neurosarcoidosis, and none of the control patients had local synthesis of specific IgG reacting with Kveim material at some stage in the disease.
Gene_expression (synthesis) of IgG associated with sarcoidosis and disease
5) Confidence 0.76 Published 1990 Journal J. Neurol. Sci. Section Abstract Doc Link 2086723 Disease Relevance 0.55 Pain Relevance 0.14
Indeed, Hamilton et al74 demonstrated such an immune response to injection of CHC for the treatment of PD plaques: pretreatment, anticollagenase IgG was detected in 34% of the healthy controls vs 58% of untreated PD patients.
Gene_expression (detected) of IgG in plaques associated with penile induration
6) Confidence 0.75 Published 2010 Journal Therapeutics and Clinical Risk Management Section Body Doc Link PMC2988615 Disease Relevance 0.27 Pain Relevance 0
Local synthesis of Kveim-specific IgG was not found in patients who had received in the past, or were still receiving, immunomodulating agents, and local synthesis was abolished when such treatment was introduced to those patients who had been positive.
Gene_expression (synthesis) of IgG
7) Confidence 0.66 Published 1990 Journal J. Neurol. Sci. Section Abstract Doc Link 2086723 Disease Relevance 0.49 Pain Relevance 0.12
Six of the 8 (75%) patients with definite neurosarcoidosis who had never received steroids or immunosuppressants had local synthesis of Kveim-specific IgG.
Gene_expression (synthesis) of IgG
8) Confidence 0.66 Published 1990 Journal J. Neurol. Sci. Section Abstract Doc Link 2086723 Disease Relevance 0.50 Pain Relevance 0.12
Those patients whose cerebrospinal fluid showed local synthesis of oligoclonal total IgG were more likely to have local synthesis of Kveim-specific IgG, but not necessarily in an oligoclonal fashion.
Gene_expression (synthesis) of IgG in cerebrospinal fluid
9) Confidence 0.66 Published 1990 Journal J. Neurol. Sci. Section Abstract Doc Link 2086723 Disease Relevance 0.40 Pain Relevance 0.10
Although both Bartonella-specific IgG and IgM antibodies were negative before the scratch, the IgG antibody titer rose to 1:512 14 weeks after the onset.
Neg (negative) Gene_expression (negative) of IgG
10) Confidence 0.66 Published 2000 Journal J. Vet. Med. Sci. Section Abstract Doc Link 11193351 Disease Relevance 0.87 Pain Relevance 0.24
A study of pregnant and lactating rats compared TN3 PEGylated FabÂ’ (comparable to certolizumab) and TN3 IgG1 antibody (comparable to the classic anti-TNF?
Gene_expression (antibody) of IgG1
11) Confidence 0.65 Published 2010 Journal International Journal of Women's Health Section Body Doc Link PMC2971732 Disease Relevance 0.06 Pain Relevance 0.20
l of isotype-specific monoclonal antibody was added at 1:1000 dilution for the detection of IgA (Dako, Denmark, P0216), IgE (Vector Laboratories, UK P0720), IgG1, IgG2, IgG3, IgG4 (The Binding Site, UK, AP006, AP007, AP008 and AP009, respectively) and IgM (Dako, Denmark, P0215).
Gene_expression (detection) of IgG
12) Confidence 0.65 Published 2006 Journal BMC Infect Dis Section Body Doc Link PMC1523344 Disease Relevance 0.06 Pain Relevance 0
The relative levels of IgG subclasses produced against Sh13 differed from those against SWAP to which IgG1 and IgG4 responses were the predominant subclasses with little detectable IgG2 and IgG3 as shown in Figure 4b.
Neg (little) Gene_expression (detectable) of IgG
13) Confidence 0.65 Published 2006 Journal BMC Infect Dis Section Body Doc Link PMC1523344 Disease Relevance 0.36 Pain Relevance 0
There appeared to be higher levels of the IgG1 than the PEGylated form in the breastmilk of rats treated during pregnancy.
Gene_expression (levels) of IgG1
14) Confidence 0.65 Published 2010 Journal International Journal of Women's Health Section Body Doc Link PMC2971732 Disease Relevance 0.05 Pain Relevance 0.05
Age and age2, sex, haemoglobin phenotype and G6PD deficit as well as the individual immunoglobulin isotypes (i.e., IgG1, IgG2, IgG3, and IgG4) that were available and suspected of having a potential impact on the dependent variable (the number of malaria attacks), were tested in backward stepwise regression, eliminating, by hand, the variables which were not significant.
Gene_expression (tested) of IgG1 associated with malaria
15) Confidence 0.65 Published 2007 Journal PLoS Medicine Section Body Doc Link PMC2071934 Disease Relevance 0.33 Pain Relevance 0
Some patients may develop specific IgG without developing disease and some will lose their specific IgG during their lifetime.
Neg (without) Gene_expression (develop) of IgG associated with disease
16) Confidence 0.65 Published 2010 Journal PLoS Neglected Tropical Diseases Section Body Doc Link PMC2998433 Disease Relevance 0.73 Pain Relevance 0
The presence of IgG against these pathogens should be regarded as indices of exposure.
Gene_expression (presence) of IgG
17) Confidence 0.65 Published 2010 Journal PLoS Neglected Tropical Diseases Section Body Doc Link PMC2998433 Disease Relevance 0.73 Pain Relevance 0
Furthermore, Yamakawa9 set the positive cut-off standard, which is defined as an abnormally high IgG value at an EIA value of 50; however, in our study, only in 4 of the 65 participants of the patients with ophthalmic ZSH was an IgG of 50 or more observed, while the mean value was 18.
Gene_expression (ophthalmic) of IgG associated with zoster sine herpete
18) Confidence 0.61 Published 2010 Journal Clinical Ophthalmology (Auckland, N.Z.) Section Body Doc Link PMC2915869 Disease Relevance 1.16 Pain Relevance 0.10
Furthermore, Yamakawa9 set the positive cut-off standard, which is defined as an abnormally high IgG value at an EIA value of 50; however, in our study, only in 4 of the 65 participants of the patients with ophthalmic ZSH was an IgG of 50 or more observed, while the mean value was 18.
Gene_expression (value) of IgG associated with zoster sine herpete
19) Confidence 0.61 Published 2010 Journal Clinical Ophthalmology (Auckland, N.Z.) Section Body Doc Link PMC2915869 Disease Relevance 1.10 Pain Relevance 0.09
Furthermore, Yamakawa9 set the positive cut-off standard, which is defined as an abnormally high IgG value at an EIA value of 50; however, in our study, only in 4 of the 65 participants of the patients with ophthalmic ZSH was an IgG of 50 or more observed, while the mean value was 18.
Gene_expression (was) of IgG associated with zoster sine herpete
20) Confidence 0.61 Published 2010 Journal Clinical Ophthalmology (Auckland, N.Z.) Section Body Doc Link PMC2915869 Disease Relevance 1.15 Pain Relevance 0.10

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