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Context Info
Confidence 0.59
First Reported 1983
Last Reported 2010
Negated 2
Speculated 1
Reported most in Abstract
Documents 3
Total Number 4
Disease Relevance 1.57
Pain Relevance 1.46

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (Ibsp) extracellular region (Ibsp) cell adhesion (Ibsp)
proteinaceous extracellular matrix (Ibsp) extracellular matrix organization (Ibsp)
Anatomy Link Frequency
stromal cells 1
liver 1
duct 1
Ibsp (Rattus norvegicus)
Pain Link Frequency Relevance Heat
anesthesia 2 100.00 Very High Very High Very High
Morphine 12 99.84 Very High Very High Very High
Bile 6 99.28 Very High Very High Very High
ketamine 3 82.48 Quite High
depression 3 75.00 Quite High
cOX1 1 52.40 Quite High
Inflammation 1 42.32 Quite Low
Paracetamol 1 35.12 Quite Low
analgesia 1 32.24 Quite Low
cytokine 1 13.40 Low Low
Disease Link Frequency Relevance Heat
Acidosis 2 99.70 Very High Very High Very High
Hypercapnia 4 99.44 Very High Very High Very High
Hypoxia 5 99.20 Very High Very High Very High
Osteoporosis 41 98.38 Very High Very High Very High
Respiratory Failure 3 75.00 Quite High
INFLAMMATION 3 42.32 Quite Low
Hypothermia 1 33.52 Quite Low
Apoptosis 15 20.48 Low Low
Fracture Healing 3 19.20 Low Low
Postmenopausal Osteoporosis 2 14.16 Low Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Hypercapnia and acidosis alone did not affect BSP disposition, while hypoxia without hypercapnia decreased its plasma clearance to 5.5 +/- 0.3 ml X min-1 and increased liver levels to 339.1 +/- 35.1 micrograms X g-1.
Neg (not) Regulation (affect) of BSP in liver associated with acidosis, hypoxia and hypercapnia
1) Confidence 0.59 Published 1984 Journal Anesthesiology Section Abstract Doc Link 6731907 Disease Relevance 1.11 Pain Relevance 0.61
The aim of this study was to investigate the effect of anesthesia on the pharmacokinetics of bromosulfophthalein (BSP) with focus on biliary clearance.
Spec (investigate) Regulation (effect) of BSP associated with anesthesia
2) Confidence 0.40 Published 2009 Journal Biopharm Drug Dispos Section Abstract Doc Link 19226651 Disease Relevance 0 Pain Relevance 0.21
In duct-cannulated animals morphine had no effect on BSP concentration in bile, but did raise hepatic BSP levels while reducing bile flow and biliary BSP content.
Neg (no) Regulation (effect) of BSP in duct associated with bile and morphine
3) Confidence 0.24 Published 1983 Journal J. Pharmacol. Exp. Ther. Section Abstract Doc Link 6620173 Disease Relevance 0 Pain Relevance 0.61
Von Knoch et al. showed that a cascade of osteoblast-related genes including BMP-2, cbfa-1, type 1 collagen and Bone Sialo-Proteins (BSP) were up regulated and significantly increased in bone marrow stromal cells after BP treatment [11].
Regulation (regulated) of BSP in stromal cells associated with osteoporosis
4) Confidence 0.16 Published 2010 Journal Arthritis Res Ther Section Body Doc Link PMC2945066 Disease Relevance 0.46 Pain Relevance 0.03

General Comments

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