INT451

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Context Info
Confidence 0.62
First Reported 1979
Last Reported 2010
Negated 23
Speculated 20
Reported most in Abstract
Documents 142
Total Number 165
Disease Relevance 22.07
Pain Relevance 69.42

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (Oxt) extracellular region (Oxt) response to stress (Oxt)
cytoplasm (Oxt)
Anatomy Link Frequency
plasma 17
neurons 14
cerebrospinal fluid 6
hypothalamus 6
pituitary 6
Oxt (Rattus norvegicus)
Pain Link Frequency Relevance Heat
antagonist 426 100.00 Very High Very High Very High
agonist 262 100.00 Very High Very High Very High
narcan 207 100.00 Very High Very High Very High
Spinal cord 134 100.00 Very High Very High Very High
Opioid 122 100.00 Very High Very High Very High
Enkephalin 73 100.00 Very High Very High Very High
Endogenous opioid 70 100.00 Very High Very High Very High
Pain 69 100.00 Very High Very High Very High
anesthesia 38 100.00 Very High Very High Very High
Dynorphin 34 100.00 Very High Very High Very High
Disease Link Frequency Relevance Heat
Stress 179 100.00 Very High Very High Very High
Nociception 89 100.00 Very High Very High Very High
Urological Neuroanatomy 78 100.00 Very High Very High Very High
Aggression 40 100.00 Very High Very High Very High
Low Back Pain 13 100.00 Very High Very High Very High
Wound Healing 140 99.84 Very High Very High Very High
Hemorrhage 11 99.84 Very High Very High Very High
Decapitation 6 99.82 Very High Very High Very High
Schizophrenia 440 99.72 Very High Very High Very High
Anxiety Disorder 58 99.72 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
As the central noradrenergic nucleus locus coeruleus (LC) participates in arousal reactions and cardiovascular control, we used extracellular single-cell recording techniques to investigate a potential influence of oxytocin on LC neuronal activity.
Spec (investigate) Regulation (influence) of oxytocin in locus coeruleus associated with locus ceruleus
1) Confidence 0.62 Published 1998 Journal Neurosci. Lett. Section Abstract Doc Link 9835228 Disease Relevance 0 Pain Relevance 0.35
Changes in oxytocin content in rat brain during morphine withdrawal.
Regulation (Changes) of oxytocin in brain associated with narcan, withdrawal and morphine
2) Confidence 0.62 Published 1998 Journal Neuropeptides Section Title Doc Link 9571647 Disease Relevance 0 Pain Relevance 0.65
Changes in hypothalamic oxytocin levels during morphine tolerance.
Regulation (Changes) of oxytocin associated with tolerance and morphine
3) Confidence 0.62 Published 1997 Journal Neuropeptides Section Title Doc Link 9179867 Disease Relevance 0 Pain Relevance 0.82
The mechanisms underlying opioid regulation of oxytocin neurones were investigated at two sites.
Regulation (regulation) of oxytocin associated with opioid
4) Confidence 0.62 Published 1988 Journal Brain Res. Bull. Section Abstract Doc Link 2842005 Disease Relevance 0 Pain Relevance 0.86
The present study was performed to investigate the influences of oxytocin and its receptors on nociceptive responses in the CeA of rats.
Spec (investigate) Regulation (influences) of oxytocin in CeA associated with nociception and amygdala
5) Confidence 0.61 Published 2009 Journal Neurosci. Lett. Section Abstract Doc Link 19429063 Disease Relevance 0.34 Pain Relevance 0.52
Previous studies have suggested an involvement of enkephalins in regulation of oxytocin (OXT) and vasopressin (AVP) release, which seems to disagree with the very low affinities of Met- and Leu-enkephalin for the kappa opioid receptor.
Regulation (regulation) of oxytocin associated with kappa opioid receptor and enkephalin
6) Confidence 0.58 Published 1994 Journal J. Neuroendocrinol. Section Abstract Doc Link 8025568 Disease Relevance 0 Pain Relevance 0.58
Injections of naloxone increase the plasma oxytocin level in a time dependent manner, when the oxytocin system is stimulated by dehydration, but have no effect on basal oxytocin level.
Neg (no) Regulation (effect) of oxytocin in plasma associated with volume depletion and dehydration and narcan
7) Confidence 0.54 Published 1988 Journal Pharmacol. Toxicol. Section Abstract Doc Link 2848232 Disease Relevance 0.10 Pain Relevance 0.67
It is unclear however, if or how long-term uptake inhibition of either neurotransmitter system alone or in combination, affects oxytocin system dynamics or maternal behavior/aggression.
Regulation (affects) of oxytocin associated with neurotransmitter and aggression
8) Confidence 0.54 Published 2005 Journal Pharmacol. Biochem. Behav. Section Abstract Doc Link 15996723 Disease Relevance 0.33 Pain Relevance 0.45
The effect of the kappa-opioid receptor agonist, bremazocine, on plasma oxytocin levels in rats was measured by a sensitive radioimmunoassay.
Regulation (effect) of oxytocin in plasma associated with agonist and kappa opioid receptor
9) Confidence 0.53 Published 1989 Journal Eur. J. Pharmacol. Section Abstract Doc Link 2553430 Disease Relevance 0 Pain Relevance 0.17
Naloxone had no significant effect on the oxytocin mRNA content in labelled cells in the SON, and no effect on the proportion of labelled cells, in either the i.c.v. morphine- or i.c.v. vehicle-infused rats.
Neg (no) Regulation (effect) of oxytocin in SON associated with narcan and morphine
10) Confidence 0.52 Published 1989 Journal Brain Res. Section Abstract Doc Link 2743158 Disease Relevance 0 Pain Relevance 0.46
Previous studies have suggested an involvement of enkephalins in regulation of oxytocin (OXT) and vasopressin (AVP) release, which seems to disagree with the very low affinities of Met- and Leu-enkephalin for the kappa opioid receptor.
Regulation (regulation) of OXT associated with kappa opioid receptor and enkephalin
11) Confidence 0.51 Published 1994 Journal J. Neuroendocrinol. Section Abstract Doc Link 8025568 Disease Relevance 0 Pain Relevance 0.58
Experiment 2 determined the effect of the three OTAs on uterine oxytocin receptor number (Rn) and binding affinity (Kd).
Spec (determined) Regulation (effect) of oxytocin in uterine
12) Confidence 0.51 Published 2004 Journal In Vivo Section Abstract Doc Link 15646817 Disease Relevance 0.14 Pain Relevance 0.33
Continuous infusion of a specific angiotensin-II receptor antagonist into the lateral cerebral ventricle did not affect baseline levels of either vasopressin or oxytocin, but did significantly reduce (P < 0.05) the relaxin-induced release of both peptides.
Neg (not) Regulation (affect) of oxytocin in lateral associated with antagonist
13) Confidence 0.49 Published 1994 Journal Endocrinology Section Abstract Doc Link 8119158 Disease Relevance 0 Pain Relevance 0.09
In addition to its effects on oxytocin levels, cocaine is a potent serotonergic, dopaminergic and noradrenergic reuptake inhibitor.
Regulation (effects) of oxytocin associated with cocaine
14) Confidence 0.47 Published 2004 Journal Int. J. Dev. Neurosci. Section Abstract Doc Link 15380831 Disease Relevance 0.31 Pain Relevance 0.37
The tryptophan-deficient diet produced an increase in the basal levels of corticosterone but did not alter the basal levels of ACTH or oxytocin.
Neg (not) Regulation (alter) of oxytocin
15) Confidence 0.47 Published 2004 Journal Am. J. Physiol. Regul. Integr. Comp. Physiol. Section Abstract Doc Link 14604841 Disease Relevance 0.28 Pain Relevance 0.70
Marked changes of arginine vasopressin, oxytocin, and corticotropin-releasing hormone in hypophysial portal plasma after pituitary stalk damage in the rat.
Regulation (changes) of oxytocin in plasma
16) Confidence 0.46 Published 1995 Journal Endocrinology Section Title Doc Link 7720631 Disease Relevance 0.09 Pain Relevance 0.09
[Involvement of oxytocin in spinal cord in acupuncture analgesia].
Regulation ([Involvement) of oxytocin in spinal cord associated with pain, acupuncture, analgesia and spinal cord
17) Confidence 0.45 Published 1990 Journal Zhen Ci Yan Jiu Section Title Doc Link 2118001 Disease Relevance 0.35 Pain Relevance 1.55
Effect of oxytocin on acupuncture analgesia in the rat.
Regulation (Effect) of oxytocin associated with acupuncture and analgesia
18) Confidence 0.45 Published 2007 Journal Neuropeptides Section Title Doc Link 17664006 Disease Relevance 0.25 Pain Relevance 1.34
The effects of dopaminergic/serotonergic reuptake inhibition on maternal behavior, maternal aggression, and oxytocin in the rat.
Regulation (effects) of oxytocin associated with aggression
19) Confidence 0.45 Published 2005 Journal Pharmacol. Biochem. Behav. Section Title Doc Link 15996723 Disease Relevance 0.39 Pain Relevance 0.53
Convergent effects of oxytocin and a delta-opioid agonist in the bed nuclei of the stria terminalis of the peripartum rat.
Regulation (effects) of oxytocin associated with mu agonist
20) Confidence 0.45 Published 2003 Journal Brain Res. Section Title Doc Link 14575903 Disease Relevance 0 Pain Relevance 0.36

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