INT45101

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Context Info
Confidence 0.40
First Reported 1981
Last Reported 2010
Negated 1
Speculated 0
Reported most in Abstract
Documents 13
Total Number 13
Disease Relevance 2.20
Pain Relevance 6.55

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (Acot1) mitochondrion (Acot1) lipid metabolic process (Acot1)
cytoplasm (Acot1)
Anatomy Link Frequency
striatum 6
hippocampus 6
forearm 2
neurons 2
brain 2
Acot1 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
gABA 22 100.00 Very High Very High Very High
Morphine 18 99.98 Very High Very High Very High
tetrodotoxin 7 99.74 Very High Very High Very High
analgesia 11 99.56 Very High Very High Very High
Somatostatin 11 99.48 Very High Very High Very High
Hippocampus 37 99.38 Very High Very High Very High
Glutamate 10 99.20 Very High Very High Very High
midbrain 3 92.80 High High
cerebral cortex 4 91.88 High High
Bioavailability 6 89.60 High High
Disease Link Frequency Relevance Heat
Increased Venous Pressure Under Development 37 100.00 Very High Very High Very High
Frailty 65 99.48 Very High Very High Very High
Pressure Volume 2 Under Development 2 95.56 Very High Very High Very High
Hypertension 7 80.20 Quite High
Hypotension 1 76.36 Quite High
Cv Unclassified Under Development 1 75.04 Quite High
Volume Depletion And Dehydration 1 73.88 Quite High
Pressure And Volume Under Development 19 73.60 Quite High
Congenital Anomalies 15 67.56 Quite High
Myocardial Infarction 6 67.44 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Morphine elevated the levels of ACh in the cerebellum and striatum, cold water swimming--in the cerebellum, striatum and cortex, and physostigmine--in the striatum and hippocampus.
Positive_regulation (elevated) of Gene_expression (levels) of ACh in striatum associated with hippocampus and morphine
1) Confidence 0.40 Published 1983 Journal Neuropharmacology Section Abstract Doc Link 6621812 Disease Relevance 0 Pain Relevance 1.00
Suppression of behavior accompanying increased ACh synthesis in the brain might account, at least in part, for the preferred use of lithium in antimanic therapy.
Positive_regulation (increased) of Gene_expression (synthesis) of ACh in brain
2) Confidence 0.40 Published 1981 Journal Psychopharmacology (Berl.) Section Abstract Doc Link 6785802 Disease Relevance 0 Pain Relevance 0
The increase in the extracellular levels of GABA and ACh produced by 0.5 microM neurotensin in the hippocampus reached a maximum of about 310% for GABA and 250% for ACh.
Positive_regulation (increase) of Gene_expression (levels) of ACh in hippocampus associated with gaba and hippocampus
3) Confidence 0.32 Published 1998 Journal Neurochem. Int. Section Abstract Doc Link 9840224 Disease Relevance 0 Pain Relevance 0.94
The increase in the extracellular levels of GABA and ACh produced by 0.5 microM neurotensin in the hippocampus reached a maximum of about 310% for GABA and 250% for ACh.
Positive_regulation (increase) of Gene_expression (produced) of ACh in hippocampus associated with gaba and hippocampus
4) Confidence 0.32 Published 1998 Journal Neurochem. Int. Section Abstract Doc Link 9840224 Disease Relevance 0 Pain Relevance 0.94
The present results suggest that VIP, PACAP38 and PACAP27 presynaptically stimulate cholinergic activity in the hippocampus, which may be reflected by an increase in ACh synthesis to maintain releasable terminal stores of ACh.
Positive_regulation (increase) of Gene_expression (synthesis) of ACh in hippocampus associated with hippocampus
5) Confidence 0.26 Published 1993 Journal Brain Res. Section Abstract Doc Link 8334515 Disease Relevance 0 Pain Relevance 0.27
Tetrodotoxin blocked the increase in the release and synthesis of ACh induced by tityustoxin.
Positive_regulation (induced) of Gene_expression (synthesis) of ACh associated with tetrodotoxin
6) Confidence 0.24 Published 1982 Journal Toxicon Section Abstract Doc Link 6808708 Disease Relevance 0 Pain Relevance 0.27
Tetrodotoxin blocked the increase in the release and synthesis of ACh induced by tityustoxin.
Positive_regulation (increase) of Gene_expression (synthesis) of ACh associated with tetrodotoxin
7) Confidence 0.24 Published 1982 Journal Toxicon Section Abstract Doc Link 6808708 Disease Relevance 0 Pain Relevance 0.28
The increase in the extracellular levels of ACh produced by 1 microM SOM in the striatum reached a maximum of 200%.
Positive_regulation (increase) of Gene_expression (produced) of ACh in striatum associated with somatostatin
8) Confidence 0.19 Published 2003 Journal Brain Res. Bull. Section Abstract Doc Link 13679252 Disease Relevance 0 Pain Relevance 0.70
Morphine elevated the levels of ACh in the cerebellum and striatum, cold water swimming--in the cerebellum, striatum and cortex, and physostigmine--in the striatum and hippocampus.
Positive_regulation (elevated) of in cerebellum Gene_expression (levels) of ACh in striatum associated with hippocampus and morphine
9) Confidence 0.14 Published 1983 Journal Neuropharmacology Section Abstract Doc Link 6621812 Disease Relevance 0 Pain Relevance 1.00
Morphine elevated the levels of ACh in the cerebellum and striatum, cold water swimming--in the cerebellum, striatum and cortex, and physostigmine--in the striatum and hippocampus.
Positive_regulation (elevated) of in cortex Gene_expression (levels) of ACh in striatum associated with hippocampus and morphine
10) Confidence 0.14 Published 1983 Journal Neuropharmacology Section Abstract Doc Link 6621812 Disease Relevance 0 Pain Relevance 1.00
After treatment the ACh response increases compared to CHF (Fig. 7a), although not significantly.
Positive_regulation (increases) of Gene_expression (response) of ACh associated with frailty
11) Confidence 0.10 Published 2008 Journal Microvasc Res Section Body Doc Link PMC2666799 Disease Relevance 1.20 Pain Relevance 0.10
Assessment of NeuN/cresyl violet staining showed large areas of damage in posterior PPTg, but NADPH diaphorase staining revealed pockets of surviving nitric oxide synthase positive neurons (these are presumed ACh neurons).
Positive_regulation (presumed) of Gene_expression (neurons) of ACh in neurons
12) Confidence 0.08 Published 2008 Journal BMC Neurosci Section Body Doc Link PMC2257968 Disease Relevance 0.07 Pain Relevance 0
The vasodilatory response caused by Ach was significantly increased with valsartan as assessment of the maximal percentage change in the forearm blood flow compared with placebo; however, amlodipine does not produce a significant vasodilatation to Ach.
Positive_regulation (increased) of Neg (not) Gene_expression (produce) of Ach in forearm associated with increased venous pressure under development
13) Confidence 0.04 Published 2010 Journal Vascular Health and Risk Management Section Body Doc Link PMC2941789 Disease Relevance 0.92 Pain Relevance 0.04

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