INT45109

Context Info Confidence 0.37 First Reported 1983 Last Reported 2010 Negated 0 Speculated 0 Reported most in Body Documents 10 Total Number 14 Disease Relevance 5.77 Pain Relevance 2.69

signal transduction (C5AR1) plasma membrane (C5AR1) signal transducer activity (C5AR1)

Anatomy Link Frequency polymorphonuclear leukocytes 6 plasma 2 coronary artery 1 plugs 1 adipocytes 1 C5AR1 (Homo sapiens)

Pain Link Frequency Relevance Heat Inflammation 113 99.56 antagonist 96 98.36 Potency 4 97.92 neuralgia 1 96.56 agonist 4 93.00 Central nervous system 5 89.36 cINOD 11 80.80 rheumatoid arthritis 20 76.16 cytokine 5 57.52 Arthritis 10 36.80

Disease Link Frequency Relevance Heat Infection 24 100.00 Disease 63 99.92 INFLAMMATION 116 99.56 Obesity 20 98.96 Edema 5 98.84 Neuralgia 1 96.56 Herpes Zoster 2 96.40 Coronary Artery Disease 1 96.20 Herpes Simplex Virus Infection 2 96.16 Herpes Simplex Virus 1 79.08

Sentences Mentioned In

Key:

Protein

Mutation

Event

Anatomy

Negation

Speculation

Pain term

Disease term

C5A is capable of causing granulocyte/granulocyte interactions that lead to clumping, vasoocclusion, and the extension of infarctive damage in patients with coronary artery disease.

C5A Binding (interactions) of in coronary artery associated with coronary artery disease

1) Confidence 0.37 Published 1983 Journal Semin. Arthritis Rheum. Section Abstract Doc Link 6623096 Disease Relevance 0.37 Pain Relevance 0.19

The mechanism of action seems to be associated with the inhibition of local anaphylatoxin release (C3a and C5a) which are responsible for the acute evolution of the lesions produced by viruses of the Zoster-Varicella group and with a quick lethal effect on the parasitized cells which are selectively eliminated without affecting the adjoining normal cells of the host.

C5a Binding (associated) of associated with herpes zoster

2) Confidence 0.36 Published 1993 Journal Roum Arch Microbiol Immunol Section Abstract Doc Link 7827366 Disease Relevance 0.61 Pain Relevance 0.13

Neutrophil influx and phagocytosis are inhibited by CHIPS, which binds the C5aR, and ScpA that cleaves C5a.

C5aR Binding (binds) of in Neutrophil

3) Confidence 0.35 Published 2010 Journal J Mol Med Section Body Doc Link PMC2832872 Disease Relevance 0.47 Pain Relevance 0.12

C5a binds to its G protein-coupled receptor (C5aR) on polymorphonuclear leukocytes (PMNLs) through a high-affinity helical bundle and a low-affinity C terminus, the latter being solely responsible for receptor activation.

C5a Binding (binds) of in polymorphonuclear leukocytes

4) Confidence 0.35 Published 2004 Journal Mol. Pharmacol. Section Abstract Doc Link 15044616 Disease Relevance 0.38 Pain Relevance 0.30

C5a binds to its G protein-coupled receptor (C5aR) on polymorphonuclear leukocytes (PMNLs) through a high-affinity helical bundle and a low-affinity C terminus, the latter being solely responsible for receptor activation.

C5a Binding (binds) of in polymorphonuclear leukocytes

5) Confidence 0.35 Published 2004 Journal Mol. Pharmacol. Section Abstract Doc Link 15044616 Disease Relevance 0.37 Pain Relevance 0.29

Structure-activity relationships for 60 cyclic analogs were evaluated by competitive radioligand binding with C5a (affinity) and myeloperoxidase release (antagonist potency) from human PMNLs, with 20 compounds having high antagonist potencies (IC(50), 20 nM-1 microM).

C5a Binding (binding) of associated with antagonist and potency

6) Confidence 0.35 Published 2004 Journal Mol. Pharmacol. Section Abstract Doc Link 15044616 Disease Relevance 0.24 Pain Relevance 0.59

C5a binds to its G protein-coupled receptor (C5aR) on polymorphonuclear leukocytes (PMNLs) through a high-affinity helical bundle and a low-affinity C terminus, the latter being solely responsible for receptor activation.

C5aR Binding (binds) of in polymorphonuclear leukocytes

7) Confidence 0.35 Published 2004 Journal Mol. Pharmacol. Section Abstract Doc Link 15044616 Disease Relevance 0.38 Pain Relevance 0.30

C5a exerts its activities by binding to the G-protein-coupled C5a receptor on the plasma membrane of target cells.

C5a Binding (binding) of in plasma

8) Confidence 0.24 Published 2010 Journal Inflamm Res Section Body Doc Link PMC2902742 Disease Relevance 0.91 Pain Relevance 0.27

C5a exerts its activities by binding to the G-protein-coupled C5a receptor on the plasma membrane of target cells.

C5a Binding (binding) of in plasma

9) Confidence 0.19 Published 2010 Journal Inflamm Res Section Body Doc Link PMC2902742 Disease Relevance 0.92 Pain Relevance 0.27

To confirm the in vitro results in an in vivo model, Matrigel plugs supplemented with PBS (controls), FGF-2, C5a, or C3a were implanted subcutaneously into mice.

C5a Binding (implanted) of in plugs

10) Confidence 0.19 Published 2010 Journal Inflamm Res Section Body Doc Link PMC2902742 Disease Relevance 0.07 Pain Relevance 0

These results suggested that C5a could participate in the vascularization and accumulation of adipocytes around inflamed vessels.

C5a Binding (participate) of in adipocytes associated with obesity

11) Confidence 0.18 Published 2010 Journal Inflamm Res Section Body Doc Link PMC2902742 Disease Relevance 0.42 Pain Relevance 0.11

C5a is associated with various diseases [3–8], but efforts to develop antagonists have not yet been successful.

C5a Binding (associated) of associated with antagonist and disease

12) Confidence 0.16 Published 2010 Journal Inflamm Res Section Body Doc Link PMC2902742 Disease Relevance 0.43 Pain Relevance 0.12

C5 convertases cleave C5 into the anaphylatoxin C5a, which attracts neutrophils to the site of infection, and C5b, which forms a complex with complement proteins C6–C9 to generate the membrane attack complex

C5a Binding (complex) of in neutrophils associated with infection

13) Confidence 0.07 Published 2010 Journal J Mol Med Section Body Doc Link PMC2832872 Disease Relevance 0.10 Pain Relevance 0

C5 convertases cleave C5 into the anaphylatoxin C5a, which attracts neutrophils to the site of infection, and C5b, which forms a complex with complement proteins C6–C9 to generate the membrane attack complex

C5a Binding (attracts) of in neutrophils associated with infection

14) Confidence 0.07 Published 2010 Journal J Mol Med Section Body Doc Link PMC2832872 Disease Relevance 0.10 Pain Relevance 0

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