INT45112

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Context Info
Confidence 0.60
First Reported 1983
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 20
Total Number 20
Disease Relevance 6.49
Pain Relevance 2.85

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular region (PRB1) molecular_function (PRB1) biological_process (PRB1)
Anatomy Link Frequency
Paw 2
bone marrow 1
respiratory 1
PRB1 (Homo sapiens)
Pain Link Frequency Relevance Heat
Dismenorea 84 100.00 Very High Very High Very High
fibrosis 5 100.00 Very High Very High Very High
anesthesia 9 98.88 Very High Very High Very High
beta blocker 8 98.24 Very High Very High Very High
iatrogenic 8 97.84 Very High Very High Very High
Potency 3 90.96 High High
sodium channel 2 90.00 High High
imagery 1 80.80 Quite High
Codeine 2 74.64 Quite High
Dextromethorphan 2 73.76 Quite High
Disease Link Frequency Relevance Heat
Premenstrual Syndrome 134 100.00 Very High Very High Very High
Myelofibrosis 11 100.00 Very High Very High Very High
Reprotox - General 1 8 100.00 Very High Very High Very High
Fibrosis 4 100.00 Very High Very High Very High
Myeloproliferative Disorder 13 99.56 Very High Very High Very High
Pneumothorax 8 98.36 Very High Very High Very High
Pressure And Volume Under Development 22 98.00 Very High Very High Very High
Disease 73 97.04 Very High Very High Very High
Emergencies 34 96.40 Very High Very High Very High
Shock 1 95.20 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
In the PMS and PMDD groups, in contrast, total scores of MDQ in the late luteal phase markedly increased compared to those in the follicular phase (p < 0.01).
Positive_regulation (increased) of PMS associated with dismenorea and premenstrual syndrome
1) Confidence 0.60 Published 2007 Journal Biopsychosoc Med Section Body Doc Link PMC2253548 Disease Relevance 1.04 Pain Relevance 0.39
In conclusion, we demonstrated that positive Paw equally increases Pra and Pms in humans and alters venous return without changes in the pressure gradient (Pms - Pra).
Positive_regulation (increases) of Pms in Paw
2) Confidence 0.48 Published 2000 Journal J. Appl. Physiol. Section Abstract Doc Link 10710387 Disease Relevance 0.33 Pain Relevance 0.07
As to the PMS group, subscores of concentration (49.8 ± 9.6%) and negative affect (47.8 ± 8.3%) increased more apparently compared to the other factors.
Positive_regulation (increased) of PMS associated with dismenorea
3) Confidence 0.40 Published 2007 Journal Biopsychosoc Med Section Body Doc Link PMC2253548 Disease Relevance 1.03 Pain Relevance 0.43
We conclude that massive granulomatous lesions with the radiographic appearance of PMF can occur in association with intravenous injection of talc.
Positive_regulation (appearance) of PMF associated with fibrosis
4) Confidence 0.40 Published 1983 Journal Am. J. Clin. Pathol. Section Abstract Doc Link 6624719 Disease Relevance 0.54 Pain Relevance 0.23
Moreover, when we evaluated performance of all 9,871,960 HG-U133A probes from 40 cross-species hybridizations, we found that almost half of these probes (4,688,566) generated a detectable hybridization signal (PM-MM>20).
Positive_regulation (generated) of PM
5) Confidence 0.27 Published 2005 Journal BMC Genomics Section Body Doc Link PMC1156887 Disease Relevance 0 Pain Relevance 0
We postulated that circulating leptin concentrations are increased in premenstrual syndrome (PMS), and that this may be associated with the psychological symptoms of the disease.
Positive_regulation (increased) of PMS associated with dismenorea and disease
6) Confidence 0.25 Published 2000 Journal Hum. Reprod. Section Abstract Doc Link 11056127 Disease Relevance 0.67 Pain Relevance 0.49
In contrast, propafenone is a more potent beta-blocker than its metabolites and the beta-blocking activity during propafenone therapy is more prominent in PMs than EMs, as the parent drug accumulates in PMs.
Positive_regulation (accumulates) of PMs associated with beta blocker
7) Confidence 0.24 Published 2009 Journal Clin Pharmacokinet Section Abstract Doc Link 19817501 Disease Relevance 0.08 Pain Relevance 0.44
In contrast, propafenone is a more potent beta-blocker than its metabolites and the beta-blocking activity during propafenone therapy is more prominent in PMs than EMs, as the parent drug accumulates in PMs.
Positive_regulation (prominent) of PMs associated with beta blocker
8) Confidence 0.17 Published 2009 Journal Clin Pharmacokinet Section Abstract Doc Link 19817501 Disease Relevance 0.08 Pain Relevance 0.44
Comparison of the data from PRF-stimulated, PMF-stimulated and whole pheromone-stimulated animals
Positive_regulation (stimulated) of PMF
9) Confidence 0.17 Published 2006 Journal BMC Neurosci Section Body Doc Link PMC1550415 Disease Relevance 0 Pain Relevance 0
The available data on angiogenesis and expression of VEGF and its receptors in the bone marrow of patients with BCR-ABL1-negative myeloproliferative neoplasms (MPN) suggest that MVD is increased, especially in primary myelofibrosis (PMF), and that increased angiogenesis might inversely correlate with survival [55-58].
Positive_regulation (increased) of PMF in bone marrow associated with myeloproliferative disorder and myelofibrosis
10) Confidence 0.08 Published 2010 Journal J Angiogenes Res Section Body Doc Link PMC2902424 Disease Relevance 1.60 Pain Relevance 0.04
If PEEP were to elevate PCRIT in some parts of the circulation in excess of RAP, then the effective pressure gradient for venous flow from those regions could fall despite an unaltered (Pms-RAP) difference [41], flow limitation at PEEP would occur at higher pressures compared to ZEEP and the ability of an increased Pms to buffer the PEEP-induced decrease in venous return would be markedly less (Fig. 2b, point B).
Positive_regulation (increased) of Pms
11) Confidence 0.08 Published 2005 Journal Crit Care Section Body Doc Link PMC1414045 Disease Relevance 0.09 Pain Relevance 0
Jellinek and coworkers [36] confirmed that positive Paw equally increased RAP and Pms in patients during general anesthesia for implantation of defibrillator devices.
Positive_regulation (increased) of Pms in Paw associated with anesthesia
12) Confidence 0.08 Published 2005 Journal Crit Care Section Body Doc Link PMC1414045 Disease Relevance 0 Pain Relevance 0.10
However, as suggested by Scharf et al. [33] and later demonstrated in experimental studies [34,35], PEEP also increases Pms, thus preserving the gradient for venous return.
Positive_regulation (increases) of Pms
13) Confidence 0.08 Published 2005 Journal Crit Care Section Body Doc Link PMC1414045 Disease Relevance 0 Pain Relevance 0.09
This increase in Pms, which may be due to an increase in stressed volume or sympathoadrenal stimulation, could buffer the PEEP-induced decrease in venous return and shift the equilibrium point towards higher values of cardiac output (Fig. 2a, point C).
Positive_regulation (increase) of Pms
14) Confidence 0.07 Published 2005 Journal Crit Care Section Body Doc Link PMC1414045 Disease Relevance 0 Pain Relevance 0.10
Approximately 67,000 AICDs and 178,000 PMs were implanted in 2004 in the United States, increasing 60% and 19%, respectively, since 1997.
Positive_regulation (increasing) of PMs
15) Confidence 0.04 Published 2007 Journal J Gen Intern Med Section Abstract Doc Link PMC2359586 Disease Relevance 0.08 Pain Relevance 0
This study showed steady increases in the number of AICDs and PMs implanted between 1997 and 2001.
Positive_regulation (increases) of PMs
16) Confidence 0.04 Published 2007 Journal J Gen Intern Med Section Body Doc Link PMC2359586 Disease Relevance 0.31 Pain Relevance 0.05
For morbidity measures, this meant that the inverse association with temperature was less extreme for high PM10; for mortality measures, the association with minimum temperature became positive at high PM10 levels.
Positive_regulation (positive) of PM10
17) Confidence 0.03 Published 2006 Journal Environ Health Perspect Section Body Doc Link PMC1665419 Disease Relevance 0 Pain Relevance 0
In particular, more adverse outcomes were evident with increasing temperature when PM10 levels also increased.
Positive_regulation (increased) of PM10
18) Confidence 0.02 Published 2006 Journal Environ Health Perspect Section Body Doc Link PMC1665419 Disease Relevance 0.31 Pain Relevance 0
The enhanced adverse temperature effects were found at higher levels of PM10, but no clear evidence emerged for interactive effects on respiratory and cardiovascular emergency visits.
Positive_regulation (levels) of PM10 in respiratory associated with emergencies
19) Confidence 0.02 Published 2006 Journal Environ Health Perspect Section Abstract Doc Link PMC1665419 Disease Relevance 0.25 Pain Relevance 0
The temperature effects were more adverse at high levels of PM10.
Positive_regulation (levels) of PM10
20) Confidence 0.02 Published 2006 Journal Environ Health Perspect Section Body Doc Link PMC1665419 Disease Relevance 0.08 Pain Relevance 0

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