INT45113

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Context Info
Confidence 0.10
First Reported 1983
Last Reported 2010
Negated 0
Speculated 0
Reported most in Abstract
Documents 2
Total Number 2
Disease Relevance 1.00
Pain Relevance 0.33

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

peptidase activity (PGC) extracellular space (PGC) extracellular region (PGC)
nucleolus (PGC) nucleus (PGC)
Anatomy Link Frequency
esophagus 2
lumen 2
PGC (Homo sapiens)
Pain Link Frequency Relevance Heat
Bile 14 97.66 Very High Very High Very High
peptic ulcer disease 2 87.96 High High
fibrosis 1 37.72 Quite Low
Central nervous system 3 5.00 Very Low Very Low Very Low
Pain 3 5.00 Very Low Very Low Very Low
Visceral pain 3 5.00 Very Low Very Low Very Low
agonist 2 5.00 Very Low Very Low Very Low
sSRI 1 5.00 Very Low Very Low Very Low
Angina 1 5.00 Very Low Very Low Very Low
tricyclic antidepressant 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Duodenal Ulcer 2 93.80 High High
Ulcers 4 92.44 High High
Metaplasia 1 91.32 High High
Disease 8 87.96 High High
Dyspepsia 5 72.12 Quite High
Esophageal Disease 4 70.88 Quite High
Acid Reflux 15 39.00 Quite Low
Cystic Fibrosis 1 37.72 Quite Low
Hypersensitivity 7 34.08 Quite Low
Bile Reflux 4 30.88 Quite Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The authors speculated that pepsin and bile acids in weakly acidic conditions could be relevant for Barrett's transformation.42 They suggested that proteolytic activity of pepsin is maintained up to pH 5.5 and denaturation occurs at pH > 7.43 Furthermore, bile acids can impair esophageal mucosal integrity also in a weakly acidic environment.32 Therefore, the authors suggested that regression of intestinal metaplasia with long-term PPI therapy would not be expected with persistence of weakly acidic containing bile acids, and in fact it has been reported that regression can occur in only 30% of short-segment Barrett's esophagus patients.44

The Role of DGER in PPI Failure

Positive_regulation (maintained) of Positive_regulation (activity) of pepsin in esophagus associated with bile and metaplasia
1) Confidence 0.10 Published 2010 Journal Journal of Neurogastroenterology and Motility Section Body Doc Link PMC2912118 Disease Relevance 0.30 Pain Relevance 0.17
One marker in particular, an elevated level of serum pepsinogen I (PG I), a pepsin precursor produced by the gastric mucosa, secreted into the stomach lumen and also appearing in the bloodstream, has been found to be associated with a subgroup of duodenal ulcer patients.
Positive_regulation (elevated) of Positive_regulation (elevated) of pepsin precursor in lumen associated with duodenal ulcer
2) Confidence 0.01 Published 1983 Journal Am. J. Phys. Anthropol. Section Abstract Doc Link 6624902 Disease Relevance 0.70 Pain Relevance 0.16

General Comments

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