INT45155

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Context Info
Confidence 0.51
First Reported 1983
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 18
Total Number 18
Disease Relevance 15.18
Pain Relevance 1.38

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

Anatomy Link Frequency
poly 3
liver 1
nasal turbinates 1
lungs 1
corneal stroma 1
Polymerase (Homo sapiens)
Pain Link Frequency Relevance Heat
cINOD 3 100.00 Very High Very High Very High
metalloproteinase 3 100.00 Very High Very High Very High
headache 9 98.08 Very High Very High Very High
depression 4 97.76 Very High Very High Very High
Kinase C 65 92.12 High High
Central nervous system 92 91.36 High High
agonist 14 88.60 High High
nMDA receptor 19 88.28 High High
Bioavailability 8 73.12 Quite High
fibrosis 15 69.72 Quite High
Disease Link Frequency Relevance Heat
INFLAMMATION 41 100.00 Very High Very High Very High
Herpes Simplex Virus 19 100.00 Very High Very High Very High
Repression 1 100.00 Very High Very High Very High
Hepatitis C Virus Infection 236 99.98 Very High Very High Very High
Virus Diseases 94 99.56 Very High Very High Very High
Cold Sores 128 99.48 Very High Very High Very High
Herpes Simplex Virus Infection 123 98.72 Very High Very High Very High
Hepatitis B Virus Infection 81 98.68 Very High Very High Very High
Headache 9 98.08 Very High Very High Very High
Depression 4 97.76 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The development of acyclovir, a potent and specific nucleoside inhibitor of the herpes DNA polymerase, was a milestone in the history of antiviral drugs in the late 1970s.
Negative_regulation (inhibitor) of polymerase
1) Confidence 0.51 Published 2004 Journal Skin Pharmacol Physiol Section Abstract Doc Link 15452407 Disease Relevance 1.06 Pain Relevance 0.03
The cytoprotective effect of dipyrone is associated with a decrease in DNA fragmentation, as assessed by electrophoresis of genomic DNA and by flow cytometry; a reduction in the percentage of condensed nuclei, as evaluated by DNA staining with Hoescht 33342 and a decrease in poly(ADP)-ribose polymerase (PARP) cleavage, as assessed by Western blotting.
Negative_regulation (decrease) of polymerase in poly
2) Confidence 0.23 Published 2001 Journal Int. Immunopharmacol. Section Abstract Doc Link 11710546 Disease Relevance 0.38 Pain Relevance 0
Most courses of rIFN-A were associated with a reduction in Dane particle-associated polymerase activity, but in no case was this change permanent.
Negative_regulation (reduction) of polymerase
3) Confidence 0.06 Published 1983 Journal J. Infect. Dis. Section Abstract Doc Link 6631076 Disease Relevance 0.61 Pain Relevance 0.10
A transcription factor is defined as a protein binding to specific DNA binding domains and subsequently regulating the transcription from DNA to RNA by activation or repression of RNA polymerase [4].
Negative_regulation (repression) of polymerase associated with repression
4) Confidence 0.05 Published 2010 Journal Reprod Biol Endocrinol Section Body Doc Link PMC2867815 Disease Relevance 0.20 Pain Relevance 0
The reduced polymerase activities of these gene constellations were consistent with the low viral titer from lungs and nasal turbinates of mice infected with reassortant viruses r3/7/8, r3/8, r3 and r2/3 (Figure 3).
Negative_regulation (reduced) of polymerase in nasal turbinates
5) Confidence 0.04 Published 2008 Journal PLoS Pathogens Section Body Doc Link PMC2374906 Disease Relevance 0 Pain Relevance 0
Its mechanism of action is the inhibition of the DNA polymerase of the virus and suppression of HBV replication. [38,39] LAM has also been shown to be safe in patients with decompensated liver disease; it is well tolerated and achieves a rapid loss of HBV DNA in the serum.
Negative_regulation (inhibition) of polymerase in liver associated with liver disease and hepatitis b virus infection
6) Confidence 0.03 Published 2006 Journal Ann Clin Microbiol Antimicrob Section Body Doc Link PMC1459192 Disease Relevance 0.96 Pain Relevance 0.13
Acyclovir is activated by HSV thymidine kinase to the monophosphate form and by cellular enzymes to acyclovir triphosphate, causing inhibition of Herpes virus DNA polymerase.
Negative_regulation (inhibition) of polymerase associated with cold sores and herpes simplex virus
7) Confidence 0.03 Published 2010 Journal Clinical Ophthalmology (Auckland, N.Z.) Section Body Doc Link PMC2925452 Disease Relevance 1.71 Pain Relevance 0
Ganciclovir triphosphate inhibits Herpes virus DNA polymerase and arrests HSV replication.6–9 Following topical application of ganciclovir, it has been shown that the drug can penetrate the corneal stroma and can reach the aqueous humor in therapeutic levels.9
Negative_regulation (inhibits) of polymerase in corneal stroma associated with cold sores and herpes simplex virus
8) Confidence 0.03 Published 2010 Journal Clinical Ophthalmology (Auckland, N.Z.) Section Body Doc Link PMC2925452 Disease Relevance 0.80 Pain Relevance 0.04
The overwhelming mechanism of action commonly evoked by antiviral therapy involves inhibition of viral DNA polymerase.
Negative_regulation (inhibition) of polymerase
9) Confidence 0.03 Published 2010 Journal Curr Neurol Neurosci Rep Section Body Doc Link PMC2842560 Disease Relevance 1.41 Pain Relevance 0.09
Anti-herpetic drugs such as foscarnet, ganciclovir, cidofovir, and acyclovir inhibit the viral DNA polymerase [107] which, therefore, only allows treatment for replicating viruses in the lytic phase of infection; latent viruses are unaffected.
Negative_regulation (inhibit) of polymerase associated with herpes simplex virus infection and infection
10) Confidence 0.02 Published 2005 Journal Virol J Section Body Doc Link PMC1243244 Disease Relevance 2.08 Pain Relevance 0.05
We showed that phosphorylation of BDV P acts as a negative regulator of the viral polymerase complex activity, in contrast to what has been shown for other Mononegavirales.
Negative_regulation (regulator) of polymerase associated with virus diseases
11) Confidence 0.02 Published 2009 Journal PLoS Pathogens Section Body Doc Link PMC2673689 Disease Relevance 0.46 Pain Relevance 0.25
Conclusion: Polymerase inhibitors, anti-inflammatory drugs, antioxidants, matrix metalloproteinase inhibitors, and probably regulators of DNA damage repair are identified as promising approaches to improve treatment.



Negative_regulation (inhibitors) of Polymerase associated with inflammation, metalloproteinase and cinod
12) Confidence 0.02 Published 2008 Journal Eplasty Section Abstract Doc Link PMC2431646 Disease Relevance 0.78 Pain Relevance 0.22
In the case of acyclovir, an acyclic deoxyguanosine analogue, three phosphorylations are required (one by a viral thymidine kinase) before activation to competitively inhibit viral DNA polymerase and intercalate into newly synthesized viral DNA to terminate viral replication.
Negative_regulation (inhibit) of polymerase
13) Confidence 0.02 Published 2010 Journal Curr Neurol Neurosci Rep Section Body Doc Link PMC2842560 Disease Relevance 1.26 Pain Relevance 0.08
HCV antiviral development involves all three of classes, HCV protease inhibitors (PIs), nucleoside HCV polymerase inhibitors (NIs), and nonnucleoside HCV polymerase inhibitors (NNIs).
Negative_regulation (inhibitors) of polymerase associated with hepatitis c virus infection
14) Confidence 0.01 Published 2009 Journal Therapeutics and Clinical Risk Management Section Body Doc Link PMC2731021 Disease Relevance 0.94 Pain Relevance 0
HCV antiviral development involves all three of classes, HCV protease inhibitors (PIs), nucleoside HCV polymerase inhibitors (NIs), and nonnucleoside HCV polymerase inhibitors (NNIs).
Negative_regulation (inhibitors) of polymerase associated with hepatitis c virus infection
15) Confidence 0.01 Published 2009 Journal Therapeutics and Clinical Risk Management Section Body Doc Link PMC2731021 Disease Relevance 0.90 Pain Relevance 0
The reduced polymerase activities of these gene constellations were consistent with the low viral titer from lungs and nasal turbinates of mice infected with reassortant viruses r3/7/8, r3/8, r3 and r2/3 (Figure 3).
Negative_regulation (reduced) of polymerase in lungs
16) Confidence 0.01 Published 2008 Journal PLoS Pathogens Section Body Doc Link PMC2374906 Disease Relevance 0 Pain Relevance 0
Damage resulting from intracortical infusion of NMDA is attenuated by an inhibitor of poly-ADP ribose polymerase (PARP), and this neuroprotection was associated with a depression in the levels of D-serine but not glycine [21].
Negative_regulation (inhibitor) of polymerase in poly associated with depression
17) Confidence 0.01 Published 2004 Journal J Neuroinflammation Section Body Doc Link PMC483052 Disease Relevance 0.29 Pain Relevance 0.40
Poly (ADP-ribose) polymerase inhibitors
Negative_regulation (inhibitors) of polymerase in Poly
18) Confidence 0.01 Published 2010 Journal Breast Cancer Res Section Body Doc Link PMC2972555 Disease Relevance 1.33 Pain Relevance 0

General Comments

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